Association of common medical comorbidities with early renal damage in the Chinese tropics with essential hypertension
Abstract Background Urine albumin/creatinine ratio (UACR) is an important marker of early renal damage (ERD) caused by hypertension. Recent studies showed that blood pressure was a significant inverse association with temperature and climate. The purposes of our study were sought to explore the asso...
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| Format: | Article |
| Language: | English |
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BMC
2021-11-01
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| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12882-021-02576-8 |
| _version_ | 1818724292190273536 |
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| author | Yuzhuo Zhang Ying Zhao Chenglu Wei Yongrong Li Hira Aslam Qingmin Feng Qing Huang Yu Zheng Feifen Lv Wei Hao Jike Li |
| author_facet | Yuzhuo Zhang Ying Zhao Chenglu Wei Yongrong Li Hira Aslam Qingmin Feng Qing Huang Yu Zheng Feifen Lv Wei Hao Jike Li |
| author_sort | Yuzhuo Zhang |
| collection | DOAJ |
| description | Abstract Background Urine albumin/creatinine ratio (UACR) is an important marker of early renal damage (ERD) caused by hypertension. Recent studies showed that blood pressure was a significant inverse association with temperature and climate. The purposes of our study were sought to explore the association of common medical comorbidities with ERD, and find independent risk factors to ERD in Chinese tropics with essential hypertension. Methods From January 2018 to December 2019, we assessed UACR in a total of 599 hypertensive Chinese Hainan patients. We defined ERD as a UACR between 30 mg/g and 300 mg/g. We analysed differences between qualitative variables using the chi-squared (χ2) test. We calculated correlations between UACR and age, hypertension duration (HD), systolic blood pressure (SBP), and diastolic blood pressure (DBP) using the Spearman’s rho test. To determine the odds ratio (OR), we evaluated binary logistic regression models. Results Among the 599 patients, 281 (46.9%) were found to have ERD. ERD and factors related to sex, body mass index (BMI), and SBP did not differ significantly (all, p>0.05). Our main findings showed that age, HD, and DBP were associated with ERD (p<0.01, respectively). Furthermore, age ≥ 65 years, HD ≥10 years, DBP ≥ 90 mmHg, SBP ≥ 160 mmHg, and diabetes differed significantly according to ERD status (p < 0.05, respectively). In multivariate analysis using stepwise regression, age (OR = 1.468), DBP (OR = 1.853), and diabetes (OR = 2.031) were significant independent predictors of ERD. The area under the receiver operating characteristic (ROC) curve was 0.677, and the sensitivity and specificity of the optimal cut-off value were 44.5 and 81.1%, respectively. Conclusions Common medical comorbidities are associated with ERD; age, DBP, and diabetes are independent risk factors for ERD in patients with essential hypertension who live in the Chinese tropics. Early monitoring of the UACR, as well as control of blood glucose and DBP, can effectively delay ERD. |
| first_indexed | 2024-12-17T21:24:06Z |
| format | Article |
| id | doaj.art-d7bd06da72dd40599df8357ad6ba35c8 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-17T21:24:06Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-d7bd06da72dd40599df8357ad6ba35c82022-12-21T21:32:05ZengBMCBMC Nephrology1471-23692021-11-0122111010.1186/s12882-021-02576-8Association of common medical comorbidities with early renal damage in the Chinese tropics with essential hypertensionYuzhuo Zhang0Ying Zhao1Chenglu Wei2Yongrong Li3Hira Aslam4Qingmin Feng5Qing Huang6Yu Zheng7Feifen Lv8Wei Hao9Jike Li10First Affiliated Hospital of Hainan Medical UniversityFirst Affiliated Hospital of Hainan Medical UniversityFirst Affiliated Hospital of Hainan Medical UniversityFirst Affiliated Hospital of Hainan Medical UniversityFirst Affiliated Hospital of Hainan Medical UniversityFirst Affiliated Hospital of Hainan Medical UniversityMarketing Department, Sanofi (Hangzhou)First Affiliated Hospital of Hainan Medical UniversityFirst Affiliated Hospital of Hainan Medical UniversityCardiovascular Department, Xi’an Hospital of Traditional Chinese MedicineFirst Affiliated Hospital of Hainan Medical UniversityAbstract Background Urine albumin/creatinine ratio (UACR) is an important marker of early renal damage (ERD) caused by hypertension. Recent studies showed that blood pressure was a significant inverse association with temperature and climate. The purposes of our study were sought to explore the association of common medical comorbidities with ERD, and find independent risk factors to ERD in Chinese tropics with essential hypertension. Methods From January 2018 to December 2019, we assessed UACR in a total of 599 hypertensive Chinese Hainan patients. We defined ERD as a UACR between 30 mg/g and 300 mg/g. We analysed differences between qualitative variables using the chi-squared (χ2) test. We calculated correlations between UACR and age, hypertension duration (HD), systolic blood pressure (SBP), and diastolic blood pressure (DBP) using the Spearman’s rho test. To determine the odds ratio (OR), we evaluated binary logistic regression models. Results Among the 599 patients, 281 (46.9%) were found to have ERD. ERD and factors related to sex, body mass index (BMI), and SBP did not differ significantly (all, p>0.05). Our main findings showed that age, HD, and DBP were associated with ERD (p<0.01, respectively). Furthermore, age ≥ 65 years, HD ≥10 years, DBP ≥ 90 mmHg, SBP ≥ 160 mmHg, and diabetes differed significantly according to ERD status (p < 0.05, respectively). In multivariate analysis using stepwise regression, age (OR = 1.468), DBP (OR = 1.853), and diabetes (OR = 2.031) were significant independent predictors of ERD. The area under the receiver operating characteristic (ROC) curve was 0.677, and the sensitivity and specificity of the optimal cut-off value were 44.5 and 81.1%, respectively. Conclusions Common medical comorbidities are associated with ERD; age, DBP, and diabetes are independent risk factors for ERD in patients with essential hypertension who live in the Chinese tropics. Early monitoring of the UACR, as well as control of blood glucose and DBP, can effectively delay ERD.https://doi.org/10.1186/s12882-021-02576-8Chinese tropicsEarly renal damageEssential hypertensionUrine albumin/creatinine ratio |
| spellingShingle | Yuzhuo Zhang Ying Zhao Chenglu Wei Yongrong Li Hira Aslam Qingmin Feng Qing Huang Yu Zheng Feifen Lv Wei Hao Jike Li Association of common medical comorbidities with early renal damage in the Chinese tropics with essential hypertension BMC Nephrology Chinese tropics Early renal damage Essential hypertension Urine albumin/creatinine ratio |
| title | Association of common medical comorbidities with early renal damage in the Chinese tropics with essential hypertension |
| title_full | Association of common medical comorbidities with early renal damage in the Chinese tropics with essential hypertension |
| title_fullStr | Association of common medical comorbidities with early renal damage in the Chinese tropics with essential hypertension |
| title_full_unstemmed | Association of common medical comorbidities with early renal damage in the Chinese tropics with essential hypertension |
| title_short | Association of common medical comorbidities with early renal damage in the Chinese tropics with essential hypertension |
| title_sort | association of common medical comorbidities with early renal damage in the chinese tropics with essential hypertension |
| topic | Chinese tropics Early renal damage Essential hypertension Urine albumin/creatinine ratio |
| url | https://doi.org/10.1186/s12882-021-02576-8 |
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