RANKL blockade alleviates peri-implant bone loss and is enhanced by anti-inflammatory microRNA-146a through TLR2/4 signaling

RANKL blockade alleviates peri-implant bone loss and is enhanced by anti-inflammatory microRNA-146a through TLR2/4 signaling

Abstract Background The present study was to determine the effect of local anti-RANKL antibody administration in the presence or absence of microRNA-146a on ligature-induced peri-implant bone resorption, and the potential role of TLR2/4 signaling in such effect. Results Titanium implants were placed...

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Bibliographic Details
Main Authors: Keqing Pan, Yang Hu, Yufeng Wang, Hao Li, Michele Patel, Danyang Wang, Zuomin Wang, Xiaozhe Han
Format: Article
Language:English
Published: SpringerOpen 2020-04-01
Series:International Journal of Implant Dentistry
Subjects:
RANKL
Bone resorption
Peri-implantitis
MiR-146a
TLR2
TLR4
Online Access:http://link.springer.com/article/10.1186/s40729-020-00210-0

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