LOW LEVEL OF ANTITHROMBIN III AS A WARNING SIGN FOR DEVELOPING THROMBOTIC COMPLICATIONS IN SURGICAL PATIENTS
Introduction. Pulmonary embolism (PE), being the most severe embolic complication, is characterised by low predictability, high mortality and incapacitation rates as well as a correspondingly high economic cost of therapy and aftercare. In this connection, the main purpose of our work is to find a w...
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| Format: | Article |
| Language: | English |
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Bashkir State Medical University
2018-08-01
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| Series: | Креативная хирургия и онкология |
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| Online Access: | https://www.surgonco.ru/jour/article/view/300 |
| _version_ | 1797872449364164608 |
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| author | K. N. Zolotukhin Ph. Krüger A. V. Samorodov |
| author_facet | K. N. Zolotukhin Ph. Krüger A. V. Samorodov |
| author_sort | K. N. Zolotukhin |
| collection | DOAJ |
| description | Introduction. Pulmonary embolism (PE), being the most severe embolic complication, is characterised by low predictability, high mortality and incapacitation rates as well as a correspondingly high economic cost of therapy and aftercare. In this connection, the main purpose of our work is to find a warning for PE development in non-cardiosurgical patients that have undergone intensive therapy under conditions of general surgical ICU, among the indicators of the haemostasis system.Materials and methods. Based at the anaesthesiology and emergency surgical department № 1 of the Kuvatov Republic Clinical Hospital (Russia), the researchers carried out an analysis of the haemostasis system in 430 patients hospitalised between 2010 and 2014. The functional activity of platelets was studied using a Biola 230LA laser platelet aggregation analyser (Russia). The determination of circulating aggregates was conducted using the Wu — Hoak method. Thromboelastography was carried out using a TEG 5000 Thromboelastograph (USA). A Stago STA Compact automated selective haemostasis analyser (France) was used to register indicators that characterise the state of endothelium, the haemostatic coagulation element and thrombosis and fibrinolysis markers.Results. Univariate analysis demonstrated a connection between nosocomial episodes of thrombosis and the following factors: emergency surgery (OR 9.1, p<0.01), peripheral vessel disease (OR 13.5, p=0.01), collapse development in pre-operation period (OR 30, p<0.01), high content of D-dimers (OR 30, p<0.01) and low content of AT III (OR 13.5, p=0.01). The results of multifactor analysis show that the significant diagnostic criteria are high D-dimer content and low AT III venous blood activity.Conclusion. A determination of high risks will enable the incidence of pulmonary embolism to be to minimised as well as provide a timely assessment of the efficiency of preventive measures carried out. |
| first_indexed | 2024-04-10T00:58:59Z |
| format | Article |
| id | doaj.art-d7bf0704c5064908a6d945d774894454 |
| institution | Directory Open Access Journal |
| issn | 2307-0501 2076-3093 |
| language | English |
| last_indexed | 2024-04-10T00:58:59Z |
| publishDate | 2018-08-01 |
| publisher | Bashkir State Medical University |
| record_format | Article |
| series | Креативная хирургия и онкология |
| spelling | doaj.art-d7bf0704c5064908a6d945d7748944542023-03-13T10:01:08ZengBashkir State Medical UniversityКреативная хирургия и онкология2307-05012076-30932018-08-0181525610.24060/2076-3093-2018-8-1-52-56262LOW LEVEL OF ANTITHROMBIN III AS A WARNING SIGN FOR DEVELOPING THROMBOTIC COMPLICATIONS IN SURGICAL PATIENTSK. N. Zolotukhin0Ph. Krüger1A. V. Samorodov2Республиканская клиническая больница им. Г.Г. КуватоваКлиника ДортмундаРеспубликанская клиническая больница им. Г.Г. КуватоваIntroduction. Pulmonary embolism (PE), being the most severe embolic complication, is characterised by low predictability, high mortality and incapacitation rates as well as a correspondingly high economic cost of therapy and aftercare. In this connection, the main purpose of our work is to find a warning for PE development in non-cardiosurgical patients that have undergone intensive therapy under conditions of general surgical ICU, among the indicators of the haemostasis system.Materials and methods. Based at the anaesthesiology and emergency surgical department № 1 of the Kuvatov Republic Clinical Hospital (Russia), the researchers carried out an analysis of the haemostasis system in 430 patients hospitalised between 2010 and 2014. The functional activity of platelets was studied using a Biola 230LA laser platelet aggregation analyser (Russia). The determination of circulating aggregates was conducted using the Wu — Hoak method. Thromboelastography was carried out using a TEG 5000 Thromboelastograph (USA). A Stago STA Compact automated selective haemostasis analyser (France) was used to register indicators that characterise the state of endothelium, the haemostatic coagulation element and thrombosis and fibrinolysis markers.Results. Univariate analysis demonstrated a connection between nosocomial episodes of thrombosis and the following factors: emergency surgery (OR 9.1, p<0.01), peripheral vessel disease (OR 13.5, p=0.01), collapse development in pre-operation period (OR 30, p<0.01), high content of D-dimers (OR 30, p<0.01) and low content of AT III (OR 13.5, p=0.01). The results of multifactor analysis show that the significant diagnostic criteria are high D-dimer content and low AT III venous blood activity.Conclusion. A determination of high risks will enable the incidence of pulmonary embolism to be to minimised as well as provide a timely assessment of the efficiency of preventive measures carried out.https://www.surgonco.ru/jour/article/view/300тромбоэмболиялегочная артерияагрегация тромбоцитовфибринолизхирургический гемостаз |
| spellingShingle | K. N. Zolotukhin Ph. Krüger A. V. Samorodov LOW LEVEL OF ANTITHROMBIN III AS A WARNING SIGN FOR DEVELOPING THROMBOTIC COMPLICATIONS IN SURGICAL PATIENTS Креативная хирургия и онкология тромбоэмболия легочная артерия агрегация тромбоцитов фибринолиз хирургический гемостаз |
| title | LOW LEVEL OF ANTITHROMBIN III AS A WARNING SIGN FOR DEVELOPING THROMBOTIC COMPLICATIONS IN SURGICAL PATIENTS |
| title_full | LOW LEVEL OF ANTITHROMBIN III AS A WARNING SIGN FOR DEVELOPING THROMBOTIC COMPLICATIONS IN SURGICAL PATIENTS |
| title_fullStr | LOW LEVEL OF ANTITHROMBIN III AS A WARNING SIGN FOR DEVELOPING THROMBOTIC COMPLICATIONS IN SURGICAL PATIENTS |
| title_full_unstemmed | LOW LEVEL OF ANTITHROMBIN III AS A WARNING SIGN FOR DEVELOPING THROMBOTIC COMPLICATIONS IN SURGICAL PATIENTS |
| title_short | LOW LEVEL OF ANTITHROMBIN III AS A WARNING SIGN FOR DEVELOPING THROMBOTIC COMPLICATIONS IN SURGICAL PATIENTS |
| title_sort | low level of antithrombin iii as a warning sign for developing thrombotic complications in surgical patients |
| topic | тромбоэмболия легочная артерия агрегация тромбоцитов фибринолиз хирургический гемостаз |
| url | https://www.surgonco.ru/jour/article/view/300 |
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