Microcephaly prevalence after the 2015 to 2016 Zika outbreak in Tangará da Serra, Brazil: a population-based study
Abstract. Objective:. Prenatal infection with the Zika virus (ZIKV) can lead to congenital Zika syndrome (CZS), characterized by microcephaly and brain injury. However, there are questions regarding the prevalence of microcephaly/CZS after the ZIKV outbreak in defined geographic areas. This study ai...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health/LWW
2022-06-01
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| Series: | Reproductive and Developmental Medicine |
| Online Access: | http://journals.lww.com/10.1097/RD9.0000000000000020 |
| _version_ | 1811239552526843904 |
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| author | Juliana Herrero da Silva Ana Claudia Pereira Terças-Trettel Juliano André Boquett Giovanny Vinicius Araujo Franca Augusto Cesar Cardoso-dos-Santos Marina Atanaka Marcelo Zagonel Oliveira Anna Pires Terra Viviane Karoline Vivi Lucia Andreia Nunes de Oliveira Lucia Schaedler Ronaldo Fernandes Santos Alves Lavinia Schuler-Faccini Yong-Qing Zhu |
| author_facet | Juliana Herrero da Silva Ana Claudia Pereira Terças-Trettel Juliano André Boquett Giovanny Vinicius Araujo Franca Augusto Cesar Cardoso-dos-Santos Marina Atanaka Marcelo Zagonel Oliveira Anna Pires Terra Viviane Karoline Vivi Lucia Andreia Nunes de Oliveira Lucia Schaedler Ronaldo Fernandes Santos Alves Lavinia Schuler-Faccini Yong-Qing Zhu |
| author_sort | Juliana Herrero da Silva |
| collection | DOAJ |
| description | Abstract. Objective:. Prenatal infection with the Zika virus (ZIKV) can lead to congenital Zika syndrome (CZS), characterized by microcephaly and brain injury. However, there are questions regarding the prevalence of microcephaly/CZS after the ZIKV outbreak in defined geographic areas. This study aimed to identify adverse outcomes in live births of fetuses exposed in utero to the ZIKV, compared to unexposed births, as well as maternal sociodemographic, delivery, and birth characteristics.
Methods:. Here, we conducted a cross-sectional observational study to investigate the characteristics of all live births in the city of Tangará da Serra, Mato Grosso, Brazil, in 2016, after the outbreak of ZIKV infection in late 2015. All live births of children to women residing in the municipality of Tangará da Serra between January 1 and December 31, 2016, were evaluated, and head circumference was measured at birth and after 24 hours. Children born with microcephaly or a maternal history of confirmed or suspected prenatal ZIKV infection were evaluated by a multidisciplinary team. The outcomes of the exposed and non-exposed children were compared. Prevalence ratios and their respective 95% confidence intervals were calculated for sociodemographic, delivery, and live birth characteristics.
Results:. Of 1,441 live births, 106 (7.3%) were from mothers with confirmed or highly probable exposure to ZIKV. The prevalence of severe congenital microcephaly (41.7/10,000) in Tangará da Serra in 2016 was ten-fold higher than that in Latin America before 2015.
Conclusion:. This study may serve as a model to investigate possible outbreaks of infections in a defined geographical space in the future. |
| first_indexed | 2024-04-12T13:03:04Z |
| format | Article |
| id | doaj.art-d7c659d6be9c437eb43390f557f0318c |
| institution | Directory Open Access Journal |
| issn | 2096-2924 2589-8728 |
| language | English |
| last_indexed | 2024-04-12T13:03:04Z |
| publishDate | 2022-06-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Reproductive and Developmental Medicine |
| spelling | doaj.art-d7c659d6be9c437eb43390f557f0318c2022-12-22T03:32:08ZengWolters Kluwer Health/LWWReproductive and Developmental Medicine2096-29242589-87282022-06-01629810310.1097/RD9.0000000000000020202206000-00006Microcephaly prevalence after the 2015 to 2016 Zika outbreak in Tangará da Serra, Brazil: a population-based studyJuliana Herrero da SilvaAna Claudia Pereira Terças-TrettelJuliano André BoquettGiovanny Vinicius Araujo FrancaAugusto Cesar Cardoso-dos-SantosMarina AtanakaMarcelo Zagonel OliveiraAnna Pires TerraViviane Karoline ViviLucia Andreia Nunes de OliveiraLucia SchaedlerRonaldo Fernandes Santos AlvesLavinia Schuler-FacciniYong-Qing ZhuAbstract. Objective:. Prenatal infection with the Zika virus (ZIKV) can lead to congenital Zika syndrome (CZS), characterized by microcephaly and brain injury. However, there are questions regarding the prevalence of microcephaly/CZS after the ZIKV outbreak in defined geographic areas. This study aimed to identify adverse outcomes in live births of fetuses exposed in utero to the ZIKV, compared to unexposed births, as well as maternal sociodemographic, delivery, and birth characteristics. Methods:. Here, we conducted a cross-sectional observational study to investigate the characteristics of all live births in the city of Tangará da Serra, Mato Grosso, Brazil, in 2016, after the outbreak of ZIKV infection in late 2015. All live births of children to women residing in the municipality of Tangará da Serra between January 1 and December 31, 2016, were evaluated, and head circumference was measured at birth and after 24 hours. Children born with microcephaly or a maternal history of confirmed or suspected prenatal ZIKV infection were evaluated by a multidisciplinary team. The outcomes of the exposed and non-exposed children were compared. Prevalence ratios and their respective 95% confidence intervals were calculated for sociodemographic, delivery, and live birth characteristics. Results:. Of 1,441 live births, 106 (7.3%) were from mothers with confirmed or highly probable exposure to ZIKV. The prevalence of severe congenital microcephaly (41.7/10,000) in Tangará da Serra in 2016 was ten-fold higher than that in Latin America before 2015. Conclusion:. This study may serve as a model to investigate possible outbreaks of infections in a defined geographical space in the future.http://journals.lww.com/10.1097/RD9.0000000000000020 |
| spellingShingle | Juliana Herrero da Silva Ana Claudia Pereira Terças-Trettel Juliano André Boquett Giovanny Vinicius Araujo Franca Augusto Cesar Cardoso-dos-Santos Marina Atanaka Marcelo Zagonel Oliveira Anna Pires Terra Viviane Karoline Vivi Lucia Andreia Nunes de Oliveira Lucia Schaedler Ronaldo Fernandes Santos Alves Lavinia Schuler-Faccini Yong-Qing Zhu Microcephaly prevalence after the 2015 to 2016 Zika outbreak in Tangará da Serra, Brazil: a population-based study Reproductive and Developmental Medicine |
| title | Microcephaly prevalence after the 2015 to 2016 Zika outbreak in Tangará da Serra, Brazil: a population-based study |
| title_full | Microcephaly prevalence after the 2015 to 2016 Zika outbreak in Tangará da Serra, Brazil: a population-based study |
| title_fullStr | Microcephaly prevalence after the 2015 to 2016 Zika outbreak in Tangará da Serra, Brazil: a population-based study |
| title_full_unstemmed | Microcephaly prevalence after the 2015 to 2016 Zika outbreak in Tangará da Serra, Brazil: a population-based study |
| title_short | Microcephaly prevalence after the 2015 to 2016 Zika outbreak in Tangará da Serra, Brazil: a population-based study |
| title_sort | microcephaly prevalence after the 2015 to 2016 zika outbreak in tangara da serra brazil a population based study |
| url | http://journals.lww.com/10.1097/RD9.0000000000000020 |
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