The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5

The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5

UHRF1-dependent ubiquitin signaling plays an integral role in the regulation of maintenance DNA methylation. UHRF1 catalyzes transient dual mono-ubiquitylation of PAF15 (PAF15Ub2), which regulates the localization and activation of DNMT1 at DNA methylation sites during DNA replication. Although the...

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Bibliographic Details
Main Authors: Ryota Miyashita, Atsuya Nishiyama, Weihua Qin, Yoshie Chiba, Satomi Kori, Norie Kato, Chieko Konishi, Soichiro Kumamoto, Hiroko Kozuka-Hata, Masaaki Oyama, Yoshitaka Kawasoe, Toshiki Tsurimoto, Tatsuro S Takahashi, Heinrich Leonhardt, Kyohei Arita, Makoto Nakanishi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-02-01
Series:eLife
Subjects:
DNA methylation
DNMT1
USP7
ATAD5
PAF15
Online Access:https://elifesciences.org/articles/79013

Internet

https://elifesciences.org/articles/79013

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