IgA-producing B cells in lung homeostasis and disease
Immunoglobulin A (IgA) is the most abundant Ig in mucosae where it plays key roles in host defense against pathogens and in mucosal immunoregulation. Whereas intense research has established the different roles of secretory IgA in the gut, its function has been much less studied in the lung. This re...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1117749/full |
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| author | Youri Bertrand Alba Sánchez-Montalvo Alba Sánchez-Montalvo Valérie Hox Valérie Hox Antoine Froidure Antoine Froidure Charles Pilette Charles Pilette |
| author_facet | Youri Bertrand Alba Sánchez-Montalvo Alba Sánchez-Montalvo Valérie Hox Valérie Hox Antoine Froidure Antoine Froidure Charles Pilette Charles Pilette |
| author_sort | Youri Bertrand |
| collection | DOAJ |
| description | Immunoglobulin A (IgA) is the most abundant Ig in mucosae where it plays key roles in host defense against pathogens and in mucosal immunoregulation. Whereas intense research has established the different roles of secretory IgA in the gut, its function has been much less studied in the lung. This review will first summarize the state-of-the-art knowledge on the distribution and phenotype of IgA+ B cells in the human lung in both homeostasis and disease. Second, it will analyze the studies looking at cellular and molecular mechanisms of homing and priming of IgA+ B cells in the lung, notably following immunization. Lastly, published data on observations related to IgA and IgA+ B cells in lung and airway disease such as asthma, cystic fibrosis, idiopathic pulmonary fibrosis, or chronic rhinosinusitis, will be discussed. Collectively it provides the state-of-the-art of our current understanding of the biology of IgA-producing cells in the airways and identifies gaps that future research should address in order to improve mucosal protection against lung infections and chronic inflammatory diseases. |
| first_indexed | 2024-04-10T06:33:25Z |
| format | Article |
| id | doaj.art-d7cb39fc6a9547b7a28a9d910fca3738 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T06:33:25Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d7cb39fc6a9547b7a28a9d910fca37382023-03-01T05:03:43ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-03-011410.3389/fimmu.2023.11177491117749IgA-producing B cells in lung homeostasis and diseaseYouri Bertrand0Alba Sánchez-Montalvo1Alba Sánchez-Montalvo2Valérie Hox3Valérie Hox4Antoine Froidure5Antoine Froidure6Charles Pilette7Charles Pilette8Centre de Pneumologie, Otorhinolaryngologie (ORL) et Dermatologie, Institut de Recherche Expérimentale et Clinique, Faculté de Pharmacie et des Sciences Biomédicales, Université Catholique de Louvain, Brussels, BelgiumCentre de Pneumologie, Otorhinolaryngologie (ORL) et Dermatologie, Institut de Recherche Expérimentale et Clinique, Faculté de Pharmacie et des Sciences Biomédicales, Université Catholique de Louvain, Brussels, BelgiumAllergy and Clinical Immunology Research Group, Department of Microbiology, Immunology and Transplantation, Katholieke universiteit (KU) Leuven, Leuven, BelgiumCentre de Pneumologie, Otorhinolaryngologie (ORL) et Dermatologie, Institut de Recherche Expérimentale et Clinique, Faculté de Pharmacie et des Sciences Biomédicales, Université Catholique de Louvain, Brussels, BelgiumDepartment of Otorhinolaryngology, Cliniques Universitaires Saint-Luc, Brussels, BelgiumCentre de Pneumologie, Otorhinolaryngologie (ORL) et Dermatologie, Institut de Recherche Expérimentale et Clinique, Faculté de Pharmacie et des Sciences Biomédicales, Université Catholique de Louvain, Brussels, BelgiumService de Pneumologie, Cliniques Universitaires Saint-Luc, Brussels, BelgiumCentre de Pneumologie, Otorhinolaryngologie (ORL) et Dermatologie, Institut de Recherche Expérimentale et Clinique, Faculté de Pharmacie et des Sciences Biomédicales, Université Catholique de Louvain, Brussels, BelgiumService de Pneumologie, Cliniques Universitaires Saint-Luc, Brussels, BelgiumImmunoglobulin A (IgA) is the most abundant Ig in mucosae where it plays key roles in host defense against pathogens and in mucosal immunoregulation. Whereas intense research has established the different roles of secretory IgA in the gut, its function has been much less studied in the lung. This review will first summarize the state-of-the-art knowledge on the distribution and phenotype of IgA+ B cells in the human lung in both homeostasis and disease. Second, it will analyze the studies looking at cellular and molecular mechanisms of homing and priming of IgA+ B cells in the lung, notably following immunization. Lastly, published data on observations related to IgA and IgA+ B cells in lung and airway disease such as asthma, cystic fibrosis, idiopathic pulmonary fibrosis, or chronic rhinosinusitis, will be discussed. Collectively it provides the state-of-the-art of our current understanding of the biology of IgA-producing cells in the airways and identifies gaps that future research should address in order to improve mucosal protection against lung infections and chronic inflammatory diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1117749/fullIgA+ B cellslung B cellslung mucosal immunityupper airway immunityairway disease |
| spellingShingle | Youri Bertrand Alba Sánchez-Montalvo Alba Sánchez-Montalvo Valérie Hox Valérie Hox Antoine Froidure Antoine Froidure Charles Pilette Charles Pilette IgA-producing B cells in lung homeostasis and disease Frontiers in Immunology IgA+ B cells lung B cells lung mucosal immunity upper airway immunity airway disease |
| title | IgA-producing B cells in lung homeostasis and disease |
| title_full | IgA-producing B cells in lung homeostasis and disease |
| title_fullStr | IgA-producing B cells in lung homeostasis and disease |
| title_full_unstemmed | IgA-producing B cells in lung homeostasis and disease |
| title_short | IgA-producing B cells in lung homeostasis and disease |
| title_sort | iga producing b cells in lung homeostasis and disease |
| topic | IgA+ B cells lung B cells lung mucosal immunity upper airway immunity airway disease |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1117749/full |
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