Mass Production of Highly Active NK Cells for Cancer Immunotherapy in a GMP Conform Perfusion Bioreactor

Mass Production of Highly Active NK Cells for Cancer Immunotherapy in a GMP Conform Perfusion Bioreactor

NK cells have emerged as promising candidates for cancer immunotherapy, especially due to their ability to fight circulating tumor cells thereby preventing metastases formation. Hence several studies have been performed to generate and expand highly cytotoxic NK cells ex vivo, e.g., by using specifi...

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Bibliographic Details
Main Authors: Katharina Bröker, Evgeny Sinelnikov, Dirk Gustavus, Udo Schumacher, Ralf Pörtner, Hans Hoffmeister, Stefan Lüth, Werner Dammermann
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
natural killer cells (NK cells)
cytotoxicity
tumor immunity
immunotherapy
perfusion bioreactor
GMP
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2019.00194/full

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