Study protocol of a phase II study to evaluate safety and efficacy of neo-adjuvant pembrolizumab and radiotherapy in localized rectal cancer

Study protocol of a phase II study to evaluate safety and efficacy of neo-adjuvant pembrolizumab and radiotherapy in localized rectal cancer

Abstract Background Reshaping the tumor microenvironment by novel immunotherapies represents a key strategy to improve cancer treatment. Nevertheless, responsiveness to these treatments is often correlated with the extent of T cell infiltration at the tumor site. Remarkably, microsatellite stable re...

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Bibliographic Details
Main Authors: Claudia Corrò, Nicolas C. Buchs, Matthieu Tihy, André Durham-Faivre, Philippe Bichard, Jean-Louis Frossard, Giacomo Puppa, Thomas McKee, Arnaud Roth, Thomas Zilli, Christelle Trembleau, Mariagrazia Di Marco, Valérie Dutoit, Pierre-Yves Dietrich, Frédéric Ris, Thibaud Koessler
Format: Article
Language:English
Published: BMC 2022-07-01
Series:BMC Cancer
Subjects:
Rectal cancer
Radiotherapy
Pembrolizumab
T cell infiltration
Online Access:https://doi.org/10.1186/s12885-022-09820-w

Internet

https://doi.org/10.1186/s12885-022-09820-w

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