Modulation of Adipocyte Metabolism by Microbial Short-Chain Fatty Acids
Obesity and its complications—including type 2 diabetes, cardiovascular disease, and certain cancers—constitute a rising global epidemic that has imposed a substantial burden on health and healthcare systems over the years. It is becoming increasingly clear that there is a link between obesity and t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/10/3666 |
| _version_ | 1797513515600183296 |
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| author | Karolline S. May Laura J. den Hartigh |
| author_facet | Karolline S. May Laura J. den Hartigh |
| author_sort | Karolline S. May |
| collection | DOAJ |
| description | Obesity and its complications—including type 2 diabetes, cardiovascular disease, and certain cancers—constitute a rising global epidemic that has imposed a substantial burden on health and healthcare systems over the years. It is becoming increasingly clear that there is a link between obesity and the gut microbiota. Gut dysbiosis, characterized as microbial imbalance, has been consistently associated with obesity in both humans and animal models, and can be reversed with weight loss. Emerging evidence has shown that microbial-derived metabolites such as short-chain fatty acids (SCFAs)—including acetate, propionate, and butyrate—provide benefits to the host by impacting organs beyond the gut, including adipose tissue. In this review, we summarize what is currently known regarding the specific mechanisms that link gut-microbial-derived SCFAs with adipose tissue metabolism, such as adipogenesis, lipolysis, and inflammation. In addition, we explore indirect mechanisms by which SCFAs can modulate adipose tissue metabolism, such as via perturbation of gut hormones, as well as signaling to the brain and the liver. Understanding how the modulation of gut microbial metabolites such as SCFAs can impact adipose tissue function could lead to novel therapeutic strategies for the prevention and treatment of obesity. |
| first_indexed | 2024-03-10T06:18:37Z |
| format | Article |
| id | doaj.art-d7cd743f532841dcb58acceac7ef0100 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T06:18:37Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-d7cd743f532841dcb58acceac7ef01002023-11-22T19:32:28ZengMDPI AGNutrients2072-66432021-10-011310366610.3390/nu13103666Modulation of Adipocyte Metabolism by Microbial Short-Chain Fatty AcidsKarolline S. May0Laura J. den Hartigh1Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, WA 98109, USADepartment of Medicine, Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, WA 98109, USAObesity and its complications—including type 2 diabetes, cardiovascular disease, and certain cancers—constitute a rising global epidemic that has imposed a substantial burden on health and healthcare systems over the years. It is becoming increasingly clear that there is a link between obesity and the gut microbiota. Gut dysbiosis, characterized as microbial imbalance, has been consistently associated with obesity in both humans and animal models, and can be reversed with weight loss. Emerging evidence has shown that microbial-derived metabolites such as short-chain fatty acids (SCFAs)—including acetate, propionate, and butyrate—provide benefits to the host by impacting organs beyond the gut, including adipose tissue. In this review, we summarize what is currently known regarding the specific mechanisms that link gut-microbial-derived SCFAs with adipose tissue metabolism, such as adipogenesis, lipolysis, and inflammation. In addition, we explore indirect mechanisms by which SCFAs can modulate adipose tissue metabolism, such as via perturbation of gut hormones, as well as signaling to the brain and the liver. Understanding how the modulation of gut microbial metabolites such as SCFAs can impact adipose tissue function could lead to novel therapeutic strategies for the prevention and treatment of obesity.https://www.mdpi.com/2072-6643/13/10/3666gut microbiotaobesityhost metabolismacetatepropionatebutyrate |
| spellingShingle | Karolline S. May Laura J. den Hartigh Modulation of Adipocyte Metabolism by Microbial Short-Chain Fatty Acids Nutrients gut microbiota obesity host metabolism acetate propionate butyrate |
| title | Modulation of Adipocyte Metabolism by Microbial Short-Chain Fatty Acids |
| title_full | Modulation of Adipocyte Metabolism by Microbial Short-Chain Fatty Acids |
| title_fullStr | Modulation of Adipocyte Metabolism by Microbial Short-Chain Fatty Acids |
| title_full_unstemmed | Modulation of Adipocyte Metabolism by Microbial Short-Chain Fatty Acids |
| title_short | Modulation of Adipocyte Metabolism by Microbial Short-Chain Fatty Acids |
| title_sort | modulation of adipocyte metabolism by microbial short chain fatty acids |
| topic | gut microbiota obesity host metabolism acetate propionate butyrate |
| url | https://www.mdpi.com/2072-6643/13/10/3666 |
| work_keys_str_mv | AT karollinesmay modulationofadipocytemetabolismbymicrobialshortchainfattyacids AT laurajdenhartigh modulationofadipocytemetabolismbymicrobialshortchainfattyacids |