Improving Transungual Permeation Study Design by Increased Bovine Hoof Membrane Thickness and Subsequent Infection

Improving Transungual Permeation Study Design by Increased Bovine Hoof Membrane Thickness and Subsequent Infection

Ungual formulations are regularly tested using human nails or animal surrogates in Franz diffusion cell experiments. Membranes sometimes less than 100 µm thick are used, disregarding the higher physiological thickness of human nails and possible fungal infection. In this study, bovine hoof membranes...

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Bibliographic Details
Main Authors: Sebastian Kappes, Thilo Faber, Lotta Nelleßen, Tanju Yesilkaya, Udo Bock, Alf Lamprecht
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceutics
Subjects:
ungual permeation model
onychomycosis
bovine hoof
bifonazole
scanning electron microscopy
Online Access:https://www.mdpi.com/1999-4923/13/12/2098

Internet

https://www.mdpi.com/1999-4923/13/12/2098

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