Activated IL-1RI Signaling Pathway Induces Th17 cell Differentiation via Interferon Regulatory Factor (IRF) 4 Signaling in Patients with Relapsing Remitting Multiple Sclerosis (RR MS)

IL-1β plays a crucial role in the differentiation of human Th17 cells. We report here that IL-1RI expression is significantly increased in both naïve and memory CD4+ T cells derived from RR MS patients in comparison to healthy controls (HCs). IL-1RI expression is up-regulated in the in-vitro diffe...

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Bibliographic Details
Main Authors: Yonggang Sha, Silva Markovic-Plese
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00543/full