Activated IL-1RI Signaling Pathway Induces Th17 cell Differentiation via Interferon Regulatory Factor (IRF) 4 Signaling in Patients with Relapsing Remitting Multiple Sclerosis (RR MS)
IL-1β plays a crucial role in the differentiation of human Th17 cells. We report here that IL-1RI expression is significantly increased in both naïve and memory CD4+ T cells derived from RR MS patients in comparison to healthy controls (HCs). IL-1RI expression is up-regulated in the in-vitro diffe...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00543/full |