Effect of the methanolic extracts of different parts of Ferula assa-foetida on naloxone-induced withdrawal behavior in morphine-dependent mice
Objective: Ferula assa-foetida, a native species in Iran, is used for treatment of several diseases particularly for neurological disorders in Iranian Traditional Medicine. The aim of this study is to investigate the effect of methanolic roots, fruits, and aerial parts extracts of Ferula assa-foetid...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2017-08-01
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| Series: | Avicenna Journal of Phytomedicine |
| Subjects: | |
| Online Access: | http://ajp.mums.ac.ir/article_8853_336ec608546c5deadb4bc57b3a44dceb.pdf |
| _version_ | 1828378085005721600 |
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| author | Mahnaz Khanavi Sajad Maadani Behnaz Farahanikia Mahdieh Eftekhari Mohammad Sharifzadeh |
| author_facet | Mahnaz Khanavi Sajad Maadani Behnaz Farahanikia Mahdieh Eftekhari Mohammad Sharifzadeh |
| author_sort | Mahnaz Khanavi |
| collection | DOAJ |
| description | Objective: Ferula assa-foetida, a native species in Iran, is used for treatment of several diseases particularly for neurological disorders in Iranian Traditional Medicine. The aim of this study is to investigate the effect of methanolic roots, fruits, and aerial parts extracts of Ferula assa-foetida on withdrawal syndrome in morphine-dependent mice. Materials and Methods: Aerial parts, roots, and fruits of the plant were separately extracted with 80% MeOH. For induction of dependence, morphine (50, 50 and 75 mg/kg) was injected subcutaneously three times daily (10 am, 1 pm and 4 pm) for three days and a last dose of morphine (50 mg/kg) was administrated on the fourth day. Withdrawal syndrome was induced by injection of naloxone (5 mg/kg, intraperitoneal) 2 hr after the final dose of morphine. Different doses of the extracts were administered i.p. 60 minutes before naloxone injection and withdrawal sign was recorded 2 minutes after naloxone injection for a period of 60 minutes. Results: Pre-treatment of animals with different doses (2.5, 5, 10, 20 mg/kg) of methanolic extract of the aerial parts of F. assa-foetida caused a significant decrease in naloxone-induced behavior. Intraperitoneal administration of different doses (10, 15, 20, 25 mg/kg) of methanolic extract of the fruit significantly reduced the naloxone-induced withdrawal behavior (p |
| first_indexed | 2024-04-14T08:21:22Z |
| format | Article |
| id | doaj.art-d7cfff4eba734c27b7291092de4bdce9 |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-04-14T08:21:22Z |
| publishDate | 2017-08-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-d7cfff4eba734c27b7291092de4bdce92022-12-22T02:04:13ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492017-08-017542643510.22038/ajp.2017.17885.16968853Effect of the methanolic extracts of different parts of Ferula assa-foetida on naloxone-induced withdrawal behavior in morphine-dependent miceMahnaz Khanavi0Sajad Maadani1Behnaz Farahanikia2Mahdieh Eftekhari3Mohammad Sharifzadeh4Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC, Canada Department of Pharmacognosy, Faculty of Pharmacy and Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran.Department of Pharmacognosy, Faculty of Pharmacy and Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, IranDepartment of Pharmacognosy, Faculty of Pharmacy and Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, IranDepartment of Pharmacognosy, Faculty of Pharmacy and Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, IranDepartment of Toxicology and Pharmacology and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.Objective: Ferula assa-foetida, a native species in Iran, is used for treatment of several diseases particularly for neurological disorders in Iranian Traditional Medicine. The aim of this study is to investigate the effect of methanolic roots, fruits, and aerial parts extracts of Ferula assa-foetida on withdrawal syndrome in morphine-dependent mice. Materials and Methods: Aerial parts, roots, and fruits of the plant were separately extracted with 80% MeOH. For induction of dependence, morphine (50, 50 and 75 mg/kg) was injected subcutaneously three times daily (10 am, 1 pm and 4 pm) for three days and a last dose of morphine (50 mg/kg) was administrated on the fourth day. Withdrawal syndrome was induced by injection of naloxone (5 mg/kg, intraperitoneal) 2 hr after the final dose of morphine. Different doses of the extracts were administered i.p. 60 minutes before naloxone injection and withdrawal sign was recorded 2 minutes after naloxone injection for a period of 60 minutes. Results: Pre-treatment of animals with different doses (2.5, 5, 10, 20 mg/kg) of methanolic extract of the aerial parts of F. assa-foetida caused a significant decrease in naloxone-induced behavior. Intraperitoneal administration of different doses (10, 15, 20, 25 mg/kg) of methanolic extract of the fruit significantly reduced the naloxone-induced withdrawal behavior (phttp://ajp.mums.ac.ir/article_8853_336ec608546c5deadb4bc57b3a44dceb.pdfFerula assa-foetidaExtractGamma-aminobutyric acid (GABA)Morphine dependenceWithdrawal syndrome |
| spellingShingle | Mahnaz Khanavi Sajad Maadani Behnaz Farahanikia Mahdieh Eftekhari Mohammad Sharifzadeh Effect of the methanolic extracts of different parts of Ferula assa-foetida on naloxone-induced withdrawal behavior in morphine-dependent mice Avicenna Journal of Phytomedicine Ferula assa-foetida Extract Gamma-aminobutyric acid (GABA) Morphine dependence Withdrawal syndrome |
| title | Effect of the methanolic extracts of different parts of Ferula assa-foetida on naloxone-induced withdrawal behavior in morphine-dependent mice |
| title_full | Effect of the methanolic extracts of different parts of Ferula assa-foetida on naloxone-induced withdrawal behavior in morphine-dependent mice |
| title_fullStr | Effect of the methanolic extracts of different parts of Ferula assa-foetida on naloxone-induced withdrawal behavior in morphine-dependent mice |
| title_full_unstemmed | Effect of the methanolic extracts of different parts of Ferula assa-foetida on naloxone-induced withdrawal behavior in morphine-dependent mice |
| title_short | Effect of the methanolic extracts of different parts of Ferula assa-foetida on naloxone-induced withdrawal behavior in morphine-dependent mice |
| title_sort | effect of the methanolic extracts of different parts of ferula assa foetida on naloxone induced withdrawal behavior in morphine dependent mice |
| topic | Ferula assa-foetida Extract Gamma-aminobutyric acid (GABA) Morphine dependence Withdrawal syndrome |
| url | http://ajp.mums.ac.ir/article_8853_336ec608546c5deadb4bc57b3a44dceb.pdf |
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