Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface
Dry eye disease (DED) is a chronic ocular surface disorder, associated with inflammation, which can cause severe morbidity, visual compromise, and loss of quality of life, affecting up to 5–50% of the world population. In DED, ocular surface damage and tear film instability due to abnormal tear secr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2023;volume=71;issue=4;spage=1285;epage=1291;aulast=Jeyabalan |
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| author | Nallathambi Jeyabalan Aswathi M Pillai Pooja Khamar Rohit Shetty Rajiv R Mohan Arkasubhra Ghosh |
| author_facet | Nallathambi Jeyabalan Aswathi M Pillai Pooja Khamar Rohit Shetty Rajiv R Mohan Arkasubhra Ghosh |
| author_sort | Nallathambi Jeyabalan |
| collection | DOAJ |
| description | Dry eye disease (DED) is a chronic ocular surface disorder, associated with inflammation, which can cause severe morbidity, visual compromise, and loss of quality of life, affecting up to 5–50% of the world population. In DED, ocular surface damage and tear film instability due to abnormal tear secretion lead to ocular surface pain, discomfort, and epithelial barrier disruption. Studies have shown the involvement of autophagy regulation in dry eye disease as a pathogenic mechanism along with the inflammatory response. Autophagy is a self-degradation pathway in mammalian cells that reduces the excessive inflammation driven by the secretion of inflammatory factors in tears. Specific autophagy modulators are already available for the management of DED currently. However, growing studies on autophagy regulation in DED might further encourage the development of autophagy modulating drugs that reduce the pathological response at the ocular surface. In this review, we summarize the role of autophagy in the pathogenesis of dry eye disease and explore its therapeutic application. |
| first_indexed | 2024-03-13T10:36:27Z |
| format | Article |
| id | doaj.art-d7d0e4947d6645648c20b835150843a7 |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-03-13T10:36:27Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-d7d0e4947d6645648c20b835150843a72023-05-18T05:50:42ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892023-01-017141285129110.4103/IJO.IJO_2912_22Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surfaceNallathambi JeyabalanAswathi M PillaiPooja KhamarRohit ShettyRajiv R MohanArkasubhra GhoshDry eye disease (DED) is a chronic ocular surface disorder, associated with inflammation, which can cause severe morbidity, visual compromise, and loss of quality of life, affecting up to 5–50% of the world population. In DED, ocular surface damage and tear film instability due to abnormal tear secretion lead to ocular surface pain, discomfort, and epithelial barrier disruption. Studies have shown the involvement of autophagy regulation in dry eye disease as a pathogenic mechanism along with the inflammatory response. Autophagy is a self-degradation pathway in mammalian cells that reduces the excessive inflammation driven by the secretion of inflammatory factors in tears. Specific autophagy modulators are already available for the management of DED currently. However, growing studies on autophagy regulation in DED might further encourage the development of autophagy modulating drugs that reduce the pathological response at the ocular surface. In this review, we summarize the role of autophagy in the pathogenesis of dry eye disease and explore its therapeutic application.http://www.ijo.in/article.asp?issn=0301-4738;year=2023;volume=71;issue=4;spage=1285;epage=1291;aulast=Jeyabalanautophagy modulatorscorneal autophagyinflammationocular surface dry eye disease |
| spellingShingle | Nallathambi Jeyabalan Aswathi M Pillai Pooja Khamar Rohit Shetty Rajiv R Mohan Arkasubhra Ghosh Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface Indian Journal of Ophthalmology autophagy modulators corneal autophagy inflammation ocular surface dry eye disease |
| title | Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface |
| title_full | Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface |
| title_fullStr | Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface |
| title_full_unstemmed | Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface |
| title_short | Autophagy in dry eye disease: Therapeutic implications of autophagy modulators on the ocular surface |
| title_sort | autophagy in dry eye disease therapeutic implications of autophagy modulators on the ocular surface |
| topic | autophagy modulators corneal autophagy inflammation ocular surface dry eye disease |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2023;volume=71;issue=4;spage=1285;epage=1291;aulast=Jeyabalan |
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