Red Cell Alloimmunization and Autoimmunization in Multi-Transfused Thalassemia Patients in Sulaymaniyah Province-Iraq
Thalassemias are considered important health issues throughout Iraq, involving its Kurdistan region. This disorder, particularly its major form, needs lifelong regular transfusions. But this form of medical care is associated with various complications including red cell alloimmunization and autoim-...
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| Format: | Article |
| Language: | English |
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The Korean Society for Clinical Laboratory Science
2020-06-01
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| Series: | Korean Journal of Clinical Laboratory Science |
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| _version_ | 1818787958401007616 |
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| author | Aveen M. Raouf Abdulqader Ali Ibrahim Mohammed Nagham Ibrahim Mohammed |
| author_facet | Aveen M. Raouf Abdulqader Ali Ibrahim Mohammed Nagham Ibrahim Mohammed |
| author_sort | Aveen M. Raouf Abdulqader |
| collection | DOAJ |
| description | Thalassemias are considered important health issues throughout Iraq, involving its Kurdistan region. This disorder, particularly its major form, needs lifelong regular transfusions. But this form of medical care is associated with various complications including red cell alloimmunization and autoim-munization. This study determined the frequency and associations of alloimmunization among multi-transfused patients with -thalassemia major. The subjects were 204 patients who were registered at a thalassemia care center in Sulaymaniyah-Iraqi Kurdistan. The patients’ records were analyzed, their red cells were phenotyped for ABO/RhD antigens using the gel card method, and irregular antibody screening/identification was performed using the standard tube method. Alloantibodies were detected in 5.8% of the patients, while DAT was positive in 4% of the patients, which indicated autoantibodies. The identified alloantibodies were anti-E (2.4%), anti-C (1.4%), anti-e (1%), and anti-K (1%). A patient’s age at the start of transfusion (＞2 years) (P=0.042) and a positive history of transfusion reactions (P=0.003) were correlated with a significantly higher rate of alloantibody formation. From the results of our study, we conclude that measures to decrease the development of alloantibodies may incorporate matching for Rhesus and Kell systems and early induction of blood transfusions. |
| first_indexed | 2024-12-18T14:16:02Z |
| format | Article |
| id | doaj.art-d7d1dca6caf04d7297b787fffd96cbe7 |
| institution | Directory Open Access Journal |
| issn | 1738-3544 2288-1662 |
| language | English |
| last_indexed | 2024-12-18T14:16:02Z |
| publishDate | 2020-06-01 |
| publisher | The Korean Society for Clinical Laboratory Science |
| record_format | Article |
| series | Korean Journal of Clinical Laboratory Science |
| spelling | doaj.art-d7d1dca6caf04d7297b787fffd96cbe72022-12-21T21:05:00ZengThe Korean Society for Clinical Laboratory ScienceKorean Journal of Clinical Laboratory Science1738-35442288-16622020-06-015229810410.15324/kjcls.2020.52.2.98Red Cell Alloimmunization and Autoimmunization in Multi-Transfused Thalassemia Patients in Sulaymaniyah Province-IraqAveen M. Raouf Abdulqader0https://orcid.org/0000-0002-4301-6470Ali Ibrahim Mohammed1Nagham Ibrahim Mohammed2Department of Pathology, College of Medicine, University of Sulaymaniyah, Sulaymaniyah, IraqDepartment of Pathology, College of Medicine, University of Sulaymaniyah, Sulaymaniyah, IraqNinavah Health Directorate, Ninavah, IraqThalassemias are considered important health issues throughout Iraq, involving its Kurdistan region. This disorder, particularly its major form, needs lifelong regular transfusions. But this form of medical care is associated with various complications including red cell alloimmunization and autoim-munization. This study determined the frequency and associations of alloimmunization among multi-transfused patients with -thalassemia major. The subjects were 204 patients who were registered at a thalassemia care center in Sulaymaniyah-Iraqi Kurdistan. The patients’ records were analyzed, their red cells were phenotyped for ABO/RhD antigens using the gel card method, and irregular antibody screening/identification was performed using the standard tube method. Alloantibodies were detected in 5.8% of the patients, while DAT was positive in 4% of the patients, which indicated autoantibodies. The identified alloantibodies were anti-E (2.4%), anti-C (1.4%), anti-e (1%), and anti-K (1%). A patient’s age at the start of transfusion (＞2 years) (P=0.042) and a positive history of transfusion reactions (P=0.003) were correlated with a significantly higher rate of alloantibody formation. From the results of our study, we conclude that measures to decrease the development of alloantibodies may incorporate matching for Rhesus and Kell systems and early induction of blood transfusions.alloimmunizationautoimmunizationβ-thalassemia majorsulaymaniyahkurdistan |
| spellingShingle | Aveen M. Raouf Abdulqader Ali Ibrahim Mohammed Nagham Ibrahim Mohammed Red Cell Alloimmunization and Autoimmunization in Multi-Transfused Thalassemia Patients in Sulaymaniyah Province-Iraq Korean Journal of Clinical Laboratory Science alloimmunization autoimmunization β-thalassemia major sulaymaniyah kurdistan |
| title | Red Cell Alloimmunization and Autoimmunization in Multi-Transfused Thalassemia Patients in Sulaymaniyah Province-Iraq |
| title_full | Red Cell Alloimmunization and Autoimmunization in Multi-Transfused Thalassemia Patients in Sulaymaniyah Province-Iraq |
| title_fullStr | Red Cell Alloimmunization and Autoimmunization in Multi-Transfused Thalassemia Patients in Sulaymaniyah Province-Iraq |
| title_full_unstemmed | Red Cell Alloimmunization and Autoimmunization in Multi-Transfused Thalassemia Patients in Sulaymaniyah Province-Iraq |
| title_short | Red Cell Alloimmunization and Autoimmunization in Multi-Transfused Thalassemia Patients in Sulaymaniyah Province-Iraq |
| title_sort | red cell alloimmunization and autoimmunization in multi transfused thalassemia patients in sulaymaniyah province iraq |
| topic | alloimmunization autoimmunization β-thalassemia major sulaymaniyah kurdistan |
| work_keys_str_mv | AT aveenmraoufabdulqader redcellalloimmunizationandautoimmunizationinmultitransfusedthalassemiapatientsinsulaymaniyahprovinceiraq AT aliibrahimmohammed redcellalloimmunizationandautoimmunizationinmultitransfusedthalassemiapatientsinsulaymaniyahprovinceiraq AT naghamibrahimmohammed redcellalloimmunizationandautoimmunizationinmultitransfusedthalassemiapatientsinsulaymaniyahprovinceiraq |