Neuroligin-3-Mediated Synapse Formation Strengthens Interactions between Hippocampus and Barrel Cortex in Associative Memory
Memory traces are believed to be broadly allocated in cerebral cortices and the hippocampus. Mutual synapse innervations among these brain areas are presumably formed in associative memory. In the present study, we have used neuronal tracing by pAAV-carried fluorescent proteins and <i>neurolig...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/2/711 |
| _version_ | 1797339904713162752 |
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| author | Huajuan Xiao Yang Xu Shan Cui Jin-Hui Wang |
| author_facet | Huajuan Xiao Yang Xu Shan Cui Jin-Hui Wang |
| author_sort | Huajuan Xiao |
| collection | DOAJ |
| description | Memory traces are believed to be broadly allocated in cerebral cortices and the hippocampus. Mutual synapse innervations among these brain areas are presumably formed in associative memory. In the present study, we have used neuronal tracing by pAAV-carried fluorescent proteins and <i>neuroligin-3</i> mRNA knockdown by shRNAs to examine the role of neuroligin-3-mediated synapse formation in the interconnection between primary associative memory cells in the sensory cortices and secondary associative memory cells in the hippocampus during the acquisition and memory of associated signals. Our studies show that mutual synapse innervations between the barrel cortex and the hippocampal CA3 region emerge and are upregulated after the memories of associated whisker and odor signals come into view. These synapse interconnections are downregulated by a knockdown of neuroligin-3-mediated synapse linkages. New synapse interconnections and the strengthening of these interconnections appear to endorse the belief in an interaction between the hippocampus and sensory cortices for memory consolidation. |
| first_indexed | 2024-03-08T09:55:17Z |
| format | Article |
| id | doaj.art-d7d4134cdb5b468c9a3cbd520fcd3f7e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T09:55:17Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d7d4134cdb5b468c9a3cbd520fcd3f7e2024-01-29T13:53:27ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-01-0125271110.3390/ijms25020711Neuroligin-3-Mediated Synapse Formation Strengthens Interactions between Hippocampus and Barrel Cortex in Associative MemoryHuajuan Xiao0Yang Xu1Shan Cui2Jin-Hui Wang3Sino-Danish College, University of Chinese Academy of Sciences, Beijing 100049, ChinaCollege of Life Science, University of Chinese Academy of Sciences, Beijing 100049, ChinaInstitute of Biophysics, Chinese Academy of Sciences, Beijing 100101, ChinaCollege of Life Science, University of Chinese Academy of Sciences, Beijing 100049, ChinaMemory traces are believed to be broadly allocated in cerebral cortices and the hippocampus. Mutual synapse innervations among these brain areas are presumably formed in associative memory. In the present study, we have used neuronal tracing by pAAV-carried fluorescent proteins and <i>neuroligin-3</i> mRNA knockdown by shRNAs to examine the role of neuroligin-3-mediated synapse formation in the interconnection between primary associative memory cells in the sensory cortices and secondary associative memory cells in the hippocampus during the acquisition and memory of associated signals. Our studies show that mutual synapse innervations between the barrel cortex and the hippocampal CA3 region emerge and are upregulated after the memories of associated whisker and odor signals come into view. These synapse interconnections are downregulated by a knockdown of neuroligin-3-mediated synapse linkages. New synapse interconnections and the strengthening of these interconnections appear to endorse the belief in an interaction between the hippocampus and sensory cortices for memory consolidation.https://www.mdpi.com/1422-0067/25/2/711associative memoryhippocampusbarrel cortexsynapse connectionaxon projection |
| spellingShingle | Huajuan Xiao Yang Xu Shan Cui Jin-Hui Wang Neuroligin-3-Mediated Synapse Formation Strengthens Interactions between Hippocampus and Barrel Cortex in Associative Memory International Journal of Molecular Sciences associative memory hippocampus barrel cortex synapse connection axon projection |
| title | Neuroligin-3-Mediated Synapse Formation Strengthens Interactions between Hippocampus and Barrel Cortex in Associative Memory |
| title_full | Neuroligin-3-Mediated Synapse Formation Strengthens Interactions between Hippocampus and Barrel Cortex in Associative Memory |
| title_fullStr | Neuroligin-3-Mediated Synapse Formation Strengthens Interactions between Hippocampus and Barrel Cortex in Associative Memory |
| title_full_unstemmed | Neuroligin-3-Mediated Synapse Formation Strengthens Interactions between Hippocampus and Barrel Cortex in Associative Memory |
| title_short | Neuroligin-3-Mediated Synapse Formation Strengthens Interactions between Hippocampus and Barrel Cortex in Associative Memory |
| title_sort | neuroligin 3 mediated synapse formation strengthens interactions between hippocampus and barrel cortex in associative memory |
| topic | associative memory hippocampus barrel cortex synapse connection axon projection |
| url | https://www.mdpi.com/1422-0067/25/2/711 |
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