Roles of the vestibular system in obesity and impaired glucose metabolism in high-fat diet-fed mice.
The vestibular system controls balance, posture, blood pressure, and gaze. However, the roles of the vestibular system in energy and glucose metabolism remain unknown. We herein examined the roles of the vestibular system in obesity and impaired glucose metabolism using mice with vestibular lesions...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0228685 |
| _version_ | 1818730027218370560 |
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| author | Naoyuki Kawao Yoshimasa Takafuji Masayoshi Ishida Katsumi Okumoto Hironobu Morita Masafumi Muratani Hiroshi Kaji |
| author_facet | Naoyuki Kawao Yoshimasa Takafuji Masayoshi Ishida Katsumi Okumoto Hironobu Morita Masafumi Muratani Hiroshi Kaji |
| author_sort | Naoyuki Kawao |
| collection | DOAJ |
| description | The vestibular system controls balance, posture, blood pressure, and gaze. However, the roles of the vestibular system in energy and glucose metabolism remain unknown. We herein examined the roles of the vestibular system in obesity and impaired glucose metabolism using mice with vestibular lesions (VL) fed a high-sucrose/high-fat diet (HSHFD). VL was induced by surgery or arsenic. VL significantly suppressed body fat enhanced by HSHFD in mice. Glucose intolerance was improved by VL in mice fed HSHFD. VL blunted the levels of adipogenic factors and pro-inflammatory adipokines elevated by HSHFD in the epididymal white adipose tissue of mice. A β-blocker antagonized body fat and glucose intolerance enhanced by HSHFD in mice. The results of an RNA sequencing analysis showed that HSHFD induced alterations in genes, such as insulin-like growth factor-2 and glial fibrillary acidic protein, in the vestibular nuclei of mice through the vestibular system. In conclusion, we herein demonstrated that the dysregulation of the vestibular system influences an obese state and impaired glucose metabolism induced by HSHFD in mice. The vestibular system may contribute to the regulation of set points under excess energy conditions. |
| first_indexed | 2024-12-17T22:55:15Z |
| format | Article |
| id | doaj.art-d7d4271c68ef4561866eb8d4bb0eb181 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T22:55:15Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d7d4271c68ef4561866eb8d4bb0eb1812022-12-21T21:29:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01152e022868510.1371/journal.pone.0228685Roles of the vestibular system in obesity and impaired glucose metabolism in high-fat diet-fed mice.Naoyuki KawaoYoshimasa TakafujiMasayoshi IshidaKatsumi OkumotoHironobu MoritaMasafumi MurataniHiroshi KajiThe vestibular system controls balance, posture, blood pressure, and gaze. However, the roles of the vestibular system in energy and glucose metabolism remain unknown. We herein examined the roles of the vestibular system in obesity and impaired glucose metabolism using mice with vestibular lesions (VL) fed a high-sucrose/high-fat diet (HSHFD). VL was induced by surgery or arsenic. VL significantly suppressed body fat enhanced by HSHFD in mice. Glucose intolerance was improved by VL in mice fed HSHFD. VL blunted the levels of adipogenic factors and pro-inflammatory adipokines elevated by HSHFD in the epididymal white adipose tissue of mice. A β-blocker antagonized body fat and glucose intolerance enhanced by HSHFD in mice. The results of an RNA sequencing analysis showed that HSHFD induced alterations in genes, such as insulin-like growth factor-2 and glial fibrillary acidic protein, in the vestibular nuclei of mice through the vestibular system. In conclusion, we herein demonstrated that the dysregulation of the vestibular system influences an obese state and impaired glucose metabolism induced by HSHFD in mice. The vestibular system may contribute to the regulation of set points under excess energy conditions.https://doi.org/10.1371/journal.pone.0228685 |
| spellingShingle | Naoyuki Kawao Yoshimasa Takafuji Masayoshi Ishida Katsumi Okumoto Hironobu Morita Masafumi Muratani Hiroshi Kaji Roles of the vestibular system in obesity and impaired glucose metabolism in high-fat diet-fed mice. PLoS ONE |
| title | Roles of the vestibular system in obesity and impaired glucose metabolism in high-fat diet-fed mice. |
| title_full | Roles of the vestibular system in obesity and impaired glucose metabolism in high-fat diet-fed mice. |
| title_fullStr | Roles of the vestibular system in obesity and impaired glucose metabolism in high-fat diet-fed mice. |
| title_full_unstemmed | Roles of the vestibular system in obesity and impaired glucose metabolism in high-fat diet-fed mice. |
| title_short | Roles of the vestibular system in obesity and impaired glucose metabolism in high-fat diet-fed mice. |
| title_sort | roles of the vestibular system in obesity and impaired glucose metabolism in high fat diet fed mice |
| url | https://doi.org/10.1371/journal.pone.0228685 |
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