Increased melatonin levels in aqueous humor of patients with proliferative retinopathy in type 2 diabetes mellitus
AIM: To report the association between melatonin levels in aqueous humor and serum, and diabetic retinopathy (DR) grade in type 2 diabetic patients. METHODS: Aqueous humor and plasma samples from 26 patients with DR (in nonproliferative and proliferative stages) and 14 control subjects were collect...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2016-05-01
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| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.cn/en_publish/2016/5/20160515.pdf |
| _version_ | 1819259474537349120 |
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| author | Erdinc Aydin Semsettin Sahin |
| author_facet | Erdinc Aydin Semsettin Sahin |
| author_sort | Erdinc Aydin |
| collection | DOAJ |
| description | AIM: To report the association between melatonin levels in aqueous humor and serum, and diabetic retinopathy (DR) grade in type 2 diabetic patients.
METHODS: Aqueous humor and plasma samples from 26 patients with DR (in nonproliferative and proliferative stages) and 14 control subjects were collected during cataract surgery after 6 p.m. Melatonin concentrations were determined using an enzyme-linked immunosorbent assay (ELISA).
RESULTS: Melatonin levels were significantly higher in the aqueous humor of patients with proliferative diabetic retinopathy (PDR) [18.57±2.67 pg/mL (range 15.20-23.06) vs 13.63±2.71 pg/mL (range 10.20-20.20), P=0.0001], but not in those with nonproliferative retinopathy (NPDR) [13.79±2.56 pg/mL (range 9.80-20.10) vs 13.63±2.71 pg/mL (range 10.20-20.20), P=0.961] compared to controls. There was decrement in the plasma melatonin level of patients with PDR, but no significant differences between the plasma melatonin levels of the study groups [5.37±1.74 pg/mL (range 2.85-8.65) vs 6.11±1.90 pg/mL (range 3.13-9.41), P=0.293], or between control and DR groups [NPDR 6.11±1.90 pg/mL (range 3.13-9.41) vs control 6.15±1.91 pg/mL (range 2.18-9.86); PDR (5.37±1.74 pg/mL (range 2.85-8.65) vs control 6.15±1.91 pg/mL (range 2.18-9.86), P=0.808, P=0.264].
CONCLUSION: Elevated melatonin levels in aqueous humor in PDR may indicate the level to be associated with DR severity. |
| first_indexed | 2024-12-23T19:10:35Z |
| format | Article |
| id | doaj.art-d7d548c749c14f65b45e17dd9ef884f1 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-12-23T19:10:35Z |
| publishDate | 2016-05-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-d7d548c749c14f65b45e17dd9ef884f12022-12-21T17:34:28ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982016-05-019572172410.18240/ijo.2016.05.15Increased melatonin levels in aqueous humor of patients with proliferative retinopathy in type 2 diabetes mellitusErdinc Aydin0Semsettin Sahin1Izmir Katip Celebi University, Faculty of Medicine, Ophthalmology, Izmir 35620, TurkeyGaziosmanpasa University Faculty of Medicine, Biochemistry, Tokat 60250, TurkeyAIM: To report the association between melatonin levels in aqueous humor and serum, and diabetic retinopathy (DR) grade in type 2 diabetic patients. METHODS: Aqueous humor and plasma samples from 26 patients with DR (in nonproliferative and proliferative stages) and 14 control subjects were collected during cataract surgery after 6 p.m. Melatonin concentrations were determined using an enzyme-linked immunosorbent assay (ELISA). RESULTS: Melatonin levels were significantly higher in the aqueous humor of patients with proliferative diabetic retinopathy (PDR) [18.57±2.67 pg/mL (range 15.20-23.06) vs 13.63±2.71 pg/mL (range 10.20-20.20), P=0.0001], but not in those with nonproliferative retinopathy (NPDR) [13.79±2.56 pg/mL (range 9.80-20.10) vs 13.63±2.71 pg/mL (range 10.20-20.20), P=0.961] compared to controls. There was decrement in the plasma melatonin level of patients with PDR, but no significant differences between the plasma melatonin levels of the study groups [5.37±1.74 pg/mL (range 2.85-8.65) vs 6.11±1.90 pg/mL (range 3.13-9.41), P=0.293], or between control and DR groups [NPDR 6.11±1.90 pg/mL (range 3.13-9.41) vs control 6.15±1.91 pg/mL (range 2.18-9.86); PDR (5.37±1.74 pg/mL (range 2.85-8.65) vs control 6.15±1.91 pg/mL (range 2.18-9.86), P=0.808, P=0.264]. CONCLUSION: Elevated melatonin levels in aqueous humor in PDR may indicate the level to be associated with DR severity.http://www.ijo.cn/en_publish/2016/5/20160515.pdfaqueous humordiabetes mellitusdiabetic retinopathymelatoninmelatonin |
| spellingShingle | Erdinc Aydin Semsettin Sahin Increased melatonin levels in aqueous humor of patients with proliferative retinopathy in type 2 diabetes mellitus International Journal of Ophthalmology aqueous humor diabetes mellitus diabetic retinopathy melatonin melatonin |
| title | Increased melatonin levels in aqueous humor of patients with proliferative retinopathy in type 2 diabetes mellitus |
| title_full | Increased melatonin levels in aqueous humor of patients with proliferative retinopathy in type 2 diabetes mellitus |
| title_fullStr | Increased melatonin levels in aqueous humor of patients with proliferative retinopathy in type 2 diabetes mellitus |
| title_full_unstemmed | Increased melatonin levels in aqueous humor of patients with proliferative retinopathy in type 2 diabetes mellitus |
| title_short | Increased melatonin levels in aqueous humor of patients with proliferative retinopathy in type 2 diabetes mellitus |
| title_sort | increased melatonin levels in aqueous humor of patients with proliferative retinopathy in type 2 diabetes mellitus |
| topic | aqueous humor diabetes mellitus diabetic retinopathy melatonin melatonin |
| url | http://www.ijo.cn/en_publish/2016/5/20160515.pdf |
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