Neurobehavioral changes in mice offspring exposed to green tea during fetal and early postnatal development
Abstract Background Green tea extract (GTE) has various health promoting effects on animals and humans. However, the effects of perinatal exposure to GTE on the behavioral aspects of offspring have not been elucidated thus far. GTE was provided for pregnant female mice at concentrations of either 20...
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| Format: | Article |
| Language: | English |
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BMC
2017-06-01
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| Series: | Behavioral and Brain Functions |
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| Online Access: | http://link.springer.com/article/10.1186/s12993-017-0128-1 |
| _version_ | 1819069915853750272 |
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| author | Jamaan Ajarem Gawaher Al Rashedi Mohamed Mohany Ahmed Allam |
| author_facet | Jamaan Ajarem Gawaher Al Rashedi Mohamed Mohany Ahmed Allam |
| author_sort | Jamaan Ajarem |
| collection | DOAJ |
| description | Abstract Background Green tea extract (GTE) has various health promoting effects on animals and humans. However, the effects of perinatal exposure to GTE on the behavioral aspects of offspring have not been elucidated thus far. GTE was provided for pregnant female mice at concentrations of either 20 or 50 g/L, beginning the day of conception until the third week after delivery, postnatal day 22 (PD 22). Mice pups were subjected to behavioral testing to assess sensory motor reflexes, locomotion, anxiety, and learning on various postnatal days. Results Perinatal exposure to GTE resulted in a significant reduction in body weight, as well as earlier body hair appearance and opening of the eyes. Sensory motor reflexes exhibited faster responses and significant stimulatory effects in pups exposed to GTE. During the adolescent period, male and female offspring exhibited increased locomotor activity (on PD 22), reduced anxiety and fear (on PD 25), and enhanced memory and learning abilities (on PD 30), all in both GTE treated groups. All blood counts (RBCs, WBCs, Hb, and platelets), and glucose, cholesterol, triglyceride, and low density lipoprotein concentrations were significantly lower in the GTE-treated pups; however, there was no effect on high density lipoprotein levels. Conclusion Our data provide evidence that the high dose of GTE (50 g/L) had higher anxiolytic properties and positive effects on locomotor activities and sensory motor reflexes, as well as learning and memory of the offspring than the low dose of GTE (20 g/L). |
| first_indexed | 2024-12-21T16:57:38Z |
| format | Article |
| id | doaj.art-d7d6595eb9a04169b561131188a47e49 |
| institution | Directory Open Access Journal |
| issn | 1744-9081 |
| language | English |
| last_indexed | 2024-12-21T16:57:38Z |
| publishDate | 2017-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Behavioral and Brain Functions |
| spelling | doaj.art-d7d6595eb9a04169b561131188a47e492022-12-21T18:56:43ZengBMCBehavioral and Brain Functions1744-90812017-06-0113111410.1186/s12993-017-0128-1Neurobehavioral changes in mice offspring exposed to green tea during fetal and early postnatal developmentJamaan Ajarem0Gawaher Al Rashedi1Mohamed Mohany2Ahmed Allam3Department of Zoology, College of Sciences, Faculty of Science, King Saud UniversityDepartment of Biology, College of Sciences, Hail UniversityDepartment of Zoology, College of Sciences, Faculty of Science, King Saud UniversityDepartment of Zoology, College of Sciences, Faculty of Science, King Saud UniversityAbstract Background Green tea extract (GTE) has various health promoting effects on animals and humans. However, the effects of perinatal exposure to GTE on the behavioral aspects of offspring have not been elucidated thus far. GTE was provided for pregnant female mice at concentrations of either 20 or 50 g/L, beginning the day of conception until the third week after delivery, postnatal day 22 (PD 22). Mice pups were subjected to behavioral testing to assess sensory motor reflexes, locomotion, anxiety, and learning on various postnatal days. Results Perinatal exposure to GTE resulted in a significant reduction in body weight, as well as earlier body hair appearance and opening of the eyes. Sensory motor reflexes exhibited faster responses and significant stimulatory effects in pups exposed to GTE. During the adolescent period, male and female offspring exhibited increased locomotor activity (on PD 22), reduced anxiety and fear (on PD 25), and enhanced memory and learning abilities (on PD 30), all in both GTE treated groups. All blood counts (RBCs, WBCs, Hb, and platelets), and glucose, cholesterol, triglyceride, and low density lipoprotein concentrations were significantly lower in the GTE-treated pups; however, there was no effect on high density lipoprotein levels. Conclusion Our data provide evidence that the high dose of GTE (50 g/L) had higher anxiolytic properties and positive effects on locomotor activities and sensory motor reflexes, as well as learning and memory of the offspring than the low dose of GTE (20 g/L).http://link.springer.com/article/10.1186/s12993-017-0128-1Green teaSensory motor reflexesOffspringAnxietyMice |
| spellingShingle | Jamaan Ajarem Gawaher Al Rashedi Mohamed Mohany Ahmed Allam Neurobehavioral changes in mice offspring exposed to green tea during fetal and early postnatal development Behavioral and Brain Functions Green tea Sensory motor reflexes Offspring Anxiety Mice |
| title | Neurobehavioral changes in mice offspring exposed to green tea during fetal and early postnatal development |
| title_full | Neurobehavioral changes in mice offspring exposed to green tea during fetal and early postnatal development |
| title_fullStr | Neurobehavioral changes in mice offspring exposed to green tea during fetal and early postnatal development |
| title_full_unstemmed | Neurobehavioral changes in mice offspring exposed to green tea during fetal and early postnatal development |
| title_short | Neurobehavioral changes in mice offspring exposed to green tea during fetal and early postnatal development |
| title_sort | neurobehavioral changes in mice offspring exposed to green tea during fetal and early postnatal development |
| topic | Green tea Sensory motor reflexes Offspring Anxiety Mice |
| url | http://link.springer.com/article/10.1186/s12993-017-0128-1 |
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