POP1 inhibits MSU-induced inflammasome activation and ameliorates gout

POP1 inhibits MSU-induced inflammasome activation and ameliorates gout

Canonical inflammasomes are innate immune protein scaffolds that enable the activation of inflammatory caspase-1, and subsequently the processing and release of interleukin (IL)-1β, IL-18, and danger signals, as well as the induction of pyroptotic cell death. Inflammasome assembly and activation occ...

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Bibliographic Details
Main Authors: Lucia de Almeida, Savita Devi, Mohanalaxmi Indramohan, Qi-Quan Huang, Rojo A. Ratsimandresy, Richard M. Pope, Andrea Dorfleutner, Christian Stehlik
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
inflammasome
gout
caspase-1
inflammation
macrophage
pyrin domain
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.912069/full

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