A New Potentiomertic Sensor for a Preventing Alzheimer’s Disease Drug Based on Nano-Silver Modified Carbon Paste Electrode
Due to the importance of vitamin B6 (VB6) drug for human health, especially in the treatment of Alzheimer's disease, it is useful to develop new, simple, cheap and rapid methods for the determination of this compound. A high linear range and a sensitive potentiometric sensor for VB6 based on ca...
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| Format: | Article |
| Language: | English |
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Iranian Journal of Health, Safety and Environment
2021-06-01
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| Series: | Iranian Journal of Health, Safety and Environment |
| Subjects: | |
| Online Access: | http://ijhse.ir/index.php/IJHSE/article/view/455 |
| _version_ | 1798025730048655360 |
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| author | Rostam Shabani Laeli Badisar Razieh Moosavi |
| author_facet | Rostam Shabani Laeli Badisar Razieh Moosavi |
| author_sort | Rostam Shabani |
| collection | DOAJ |
| description | Due to the importance of vitamin B6 (VB6) drug for human health, especially in the treatment of Alzheimer's disease, it is useful to develop new, simple, cheap and rapid methods for the determination of this compound. A high linear range and a sensitive potentiometric sensor for VB6 based on carbon paste electrode (CPE) modified with synthesized silver nanoparticles by co-precipitation method were prepared. The sensor fully characterized in terms of distinctive nanoparticles quality, electrode composition, and usable pH range. Under optimal conditions, a linear calibration curve with range 1×10-6 to 1×10-2mol L−1 and a detection limit of 4.84×10-7molL−1 was obtained for VB6 determinations. The research introduces the design and construction of the nanocomposite modified CPE for simple and low-cost determination of VB6 in pharmaceutical formulation. Validation of the method indicates the suitability of the sensor for application in quantity control analysis of VB6 drug in pharmaceutical formulation preparations. |
| first_indexed | 2024-04-11T18:23:41Z |
| format | Article |
| id | doaj.art-d7dab2f67a3f49fca2b52d204c066dbe |
| institution | Directory Open Access Journal |
| issn | 2345-3206 2345-5535 |
| language | English |
| last_indexed | 2024-04-11T18:23:41Z |
| publishDate | 2021-06-01 |
| publisher | Iranian Journal of Health, Safety and Environment |
| record_format | Article |
| series | Iranian Journal of Health, Safety and Environment |
| spelling | doaj.art-d7dab2f67a3f49fca2b52d204c066dbe2022-12-22T04:09:42ZengIranian Journal of Health, Safety and EnvironmentIranian Journal of Health, Safety and Environment2345-32062345-55352021-06-017214441449211A New Potentiomertic Sensor for a Preventing Alzheimer’s Disease Drug Based on Nano-Silver Modified Carbon Paste ElectrodeRostam Shabani0Laeli Badisar1Razieh Moosavi2Department of Chemistry, Firoozabad Branch, Islamic Azad University, Firoozabad, IranDepartment of Chemistry, Firoozabad Branch, Islamic Azad University, Firoozabad, IranYoung Researchers and Elite Club, Shiraz Branch, Islamic Azad University, Shiraz, IranDue to the importance of vitamin B6 (VB6) drug for human health, especially in the treatment of Alzheimer's disease, it is useful to develop new, simple, cheap and rapid methods for the determination of this compound. A high linear range and a sensitive potentiometric sensor for VB6 based on carbon paste electrode (CPE) modified with synthesized silver nanoparticles by co-precipitation method were prepared. The sensor fully characterized in terms of distinctive nanoparticles quality, electrode composition, and usable pH range. Under optimal conditions, a linear calibration curve with range 1×10-6 to 1×10-2mol L−1 and a detection limit of 4.84×10-7molL−1 was obtained for VB6 determinations. The research introduces the design and construction of the nanocomposite modified CPE for simple and low-cost determination of VB6 in pharmaceutical formulation. Validation of the method indicates the suitability of the sensor for application in quantity control analysis of VB6 drug in pharmaceutical formulation preparations.http://ijhse.ir/index.php/IJHSE/article/view/455potentiometric sensor, modified carbon paste electrode, vitamin b6, silver nps |
| spellingShingle | Rostam Shabani Laeli Badisar Razieh Moosavi A New Potentiomertic Sensor for a Preventing Alzheimer’s Disease Drug Based on Nano-Silver Modified Carbon Paste Electrode Iranian Journal of Health, Safety and Environment potentiometric sensor, modified carbon paste electrode, vitamin b6, silver nps |
| title | A New Potentiomertic Sensor for a Preventing Alzheimer’s Disease Drug Based on Nano-Silver Modified Carbon Paste Electrode |
| title_full | A New Potentiomertic Sensor for a Preventing Alzheimer’s Disease Drug Based on Nano-Silver Modified Carbon Paste Electrode |
| title_fullStr | A New Potentiomertic Sensor for a Preventing Alzheimer’s Disease Drug Based on Nano-Silver Modified Carbon Paste Electrode |
| title_full_unstemmed | A New Potentiomertic Sensor for a Preventing Alzheimer’s Disease Drug Based on Nano-Silver Modified Carbon Paste Electrode |
| title_short | A New Potentiomertic Sensor for a Preventing Alzheimer’s Disease Drug Based on Nano-Silver Modified Carbon Paste Electrode |
| title_sort | new potentiomertic sensor for a preventing alzheimer s disease drug based on nano silver modified carbon paste electrode |
| topic | potentiometric sensor, modified carbon paste electrode, vitamin b6, silver nps |
| url | http://ijhse.ir/index.php/IJHSE/article/view/455 |
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