Upregulation of TGF-β-induced HSP27 by HSP90 inhibitors in osteoblasts

Upregulation of TGF-β-induced HSP27 by HSP90 inhibitors in osteoblasts

Abstract Background Heat shock protein (HSP) 90 functions as a molecular chaperone and is constitutively expressed and induced in response to stress in many cell types. We have previously demonstrated that transforming growth factor-β (TGF-β), the most abundant cytokine in bone cells, induces the ex...

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Main Authors: Gen Kuroyanagi, Haruhiko Tokuda, Kazuhiko Fujita, Tetsu Kawabata, Go Sakai, Woo Kim, Tomoyuki Hioki, Junko Tachi, Rie Matsushima-Nishiwaki, Takanobu Otsuka, Hiroki Iida, Osamu Kozawa
Format: Article
Language:English
Published: BMC 2022-05-01
Series:BMC Musculoskeletal Disorders
Subjects:
Heat shock protein
HSP90
HSP90 inhibitor
HSP27
TGF-β
SAPK/JNK
Online Access:https://doi.org/10.1186/s12891-022-05419-1

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