Type 2 Autoimmune Pancreatitis: A Challenge in the Differential Diagnosis of a Pancreatic Mass
Introduction: Autoimmune pancreatitis is a rare entity of unknown etiology that can mimic pancreatic cancer and whose diagnosis involves clinical, serological, imagiological, and histological findings. There are two types of autoimmune pancreatitis: type 1, in which the pancreas is involved as one p...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2017-03-01
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| Series: | GE: Portuguese Journal of Gastroenterology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/461589 |
| _version_ | 1828487566187298816 |
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| author | Cláudio Martins Paula Lago Paula Sousa Tarcísio Araújo José Davide Fernando Castro-Poças Isabel Pedroto |
| author_facet | Cláudio Martins Paula Lago Paula Sousa Tarcísio Araújo José Davide Fernando Castro-Poças Isabel Pedroto |
| author_sort | Cláudio Martins |
| collection | DOAJ |
| description | Introduction: Autoimmune pancreatitis is a rare entity of unknown etiology that can mimic pancreatic cancer and whose diagnosis involves clinical, serological, imagiological, and histological findings. There are two types of autoimmune pancreatitis: type 1, in which the pancreas is involved as one part of a systemic immunoglobulin G4-related disease, and type 2, generally without immunoglobulin G4-positive cells and without systemic involvement. Case: We report the case of a 45-year-old female, who underwent an abdominal magnetic resonance imaging for etiological study of a solid liver lesion, which revealed a tail pancreatic mass. Laboratory analyses showed normal levels of immunoglobulin G4 and negative antinuclear antibodies. Endoscopic ultrasound revealed a homogeneous and hypoechogenic lesion in the pancreatic tail with a “sausage-like” appearance. Endoscopic ultrasound-guided fine needle aspiration was inconclusive and the patient underwent a laparoscopic distal pancreatectomy. Histopathology examination confirmed the diagnosis of type 2 autoimmune pancreatitis. Conclusion: This case highlights the challenge in the diagnostic approach of a pancreatic mass, particularly in distinguishing benign from malignant disease. |
| first_indexed | 2024-12-11T09:54:04Z |
| format | Article |
| id | doaj.art-d7dc328f5daa4d9cbac223a22cad59dc |
| institution | Directory Open Access Journal |
| issn | 2341-4545 2387-1954 |
| language | English |
| last_indexed | 2024-12-11T09:54:04Z |
| publishDate | 2017-03-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | GE: Portuguese Journal of Gastroenterology |
| spelling | doaj.art-d7dc328f5daa4d9cbac223a22cad59dc2022-12-22T01:12:20ZengKarger PublishersGE: Portuguese Journal of Gastroenterology2341-45452387-19542017-03-0110.1159/000461589461589Type 2 Autoimmune Pancreatitis: A Challenge in the Differential Diagnosis of a Pancreatic MassCláudio MartinsPaula LagoPaula SousaTarcísio AraújoJosé DavideFernando Castro-PoçasIsabel PedrotoIntroduction: Autoimmune pancreatitis is a rare entity of unknown etiology that can mimic pancreatic cancer and whose diagnosis involves clinical, serological, imagiological, and histological findings. There are two types of autoimmune pancreatitis: type 1, in which the pancreas is involved as one part of a systemic immunoglobulin G4-related disease, and type 2, generally without immunoglobulin G4-positive cells and without systemic involvement. Case: We report the case of a 45-year-old female, who underwent an abdominal magnetic resonance imaging for etiological study of a solid liver lesion, which revealed a tail pancreatic mass. Laboratory analyses showed normal levels of immunoglobulin G4 and negative antinuclear antibodies. Endoscopic ultrasound revealed a homogeneous and hypoechogenic lesion in the pancreatic tail with a “sausage-like” appearance. Endoscopic ultrasound-guided fine needle aspiration was inconclusive and the patient underwent a laparoscopic distal pancreatectomy. Histopathology examination confirmed the diagnosis of type 2 autoimmune pancreatitis. Conclusion: This case highlights the challenge in the diagnostic approach of a pancreatic mass, particularly in distinguishing benign from malignant disease.http://www.karger.com/Article/FullText/461589Autoimmune pancreatitisImmunoglobulin G4Pancreatic cancer |
| spellingShingle | Cláudio Martins Paula Lago Paula Sousa Tarcísio Araújo José Davide Fernando Castro-Poças Isabel Pedroto Type 2 Autoimmune Pancreatitis: A Challenge in the Differential Diagnosis of a Pancreatic Mass GE: Portuguese Journal of Gastroenterology Autoimmune pancreatitis Immunoglobulin G4 Pancreatic cancer |
| title | Type 2 Autoimmune Pancreatitis: A Challenge in the Differential Diagnosis of a Pancreatic Mass |
| title_full | Type 2 Autoimmune Pancreatitis: A Challenge in the Differential Diagnosis of a Pancreatic Mass |
| title_fullStr | Type 2 Autoimmune Pancreatitis: A Challenge in the Differential Diagnosis of a Pancreatic Mass |
| title_full_unstemmed | Type 2 Autoimmune Pancreatitis: A Challenge in the Differential Diagnosis of a Pancreatic Mass |
| title_short | Type 2 Autoimmune Pancreatitis: A Challenge in the Differential Diagnosis of a Pancreatic Mass |
| title_sort | type 2 autoimmune pancreatitis a challenge in the differential diagnosis of a pancreatic mass |
| topic | Autoimmune pancreatitis Immunoglobulin G4 Pancreatic cancer |
| url | http://www.karger.com/Article/FullText/461589 |
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