Polysaccharides extracted from hawthorn (Crataegus pinnatifida) exhibiting protective effects against DSS/AOM-induced colorectal cancer in vivo
This study demonstrated the effect of polysaccharides extracted from hawthorn (HPS) on colon tumorigenic mice and investigated to test its mechanism in vivo. Subjects were given daily with HPS at doses of 50, 100 and 200 mg/kg b.w. for 9 weeks, while colon cancer was induced by azoxymethane (AOM) in...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623002189 |
| _version_ | 1797749202986467328 |
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| author | Lei Ma Yumiao Lang Xuelian Xin Wen Zhao Qian Zhou Jie Wang Sijun Dong |
| author_facet | Lei Ma Yumiao Lang Xuelian Xin Wen Zhao Qian Zhou Jie Wang Sijun Dong |
| author_sort | Lei Ma |
| collection | DOAJ |
| description | This study demonstrated the effect of polysaccharides extracted from hawthorn (HPS) on colon tumorigenic mice and investigated to test its mechanism in vivo. Subjects were given daily with HPS at doses of 50, 100 and 200 mg/kg b.w. for 9 weeks, while colon cancer was induced by azoxymethane (AOM) injection and daily administration of 2% (w/v) dextran sulfate sodium (DSS). The results showed that the mice fed with HPS had less colonic weight/length ratio, colonic tumors, inflammatory factors and colonic damage. It was also evidenced that HPS significantly increased apoptosis of colon cancer cells and tissue Caspase-3 levels. In addition, the application of HPS markedly increased the diversity of intestinal microbes and raised the relative abundance of Firmicutes at the phylum level. In conclusion, the study supported that HPS was effective in preventing colon cancer via reducing intestinal inflammation, increasing the rate of apoptosis and maintaining the abundance of intestinal flora. |
| first_indexed | 2024-03-12T16:15:52Z |
| format | Article |
| id | doaj.art-d7dc8fcd9ca547a5923f90440ac51d5b |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-12T16:15:52Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-d7dc8fcd9ca547a5923f90440ac51d5b2023-08-09T04:32:20ZengElsevierJournal of Functional Foods1756-46462023-08-01107105618Polysaccharides extracted from hawthorn (Crataegus pinnatifida) exhibiting protective effects against DSS/AOM-induced colorectal cancer in vivoLei Ma0Yumiao Lang1Xuelian Xin2Wen Zhao3Qian Zhou4Jie Wang5Sijun Dong6Key Laboratory of Public Health Safety of Hebei Province, College of Public Health, Hebei University, Baoding 071002, ChinaKey Laboratory of Public Health Safety of Hebei Province, College of Public Health, Hebei University, Baoding 071002, ChinaKey Laboratory of Public Health Safety of Hebei Province, College of Public Health, Hebei University, Baoding 071002, ChinaCollege of Food Science and Technology, Hebei Agricultural University, Baoding 071002, ChinaCollege of Food Science and Technology, Hebei Agricultural University, Baoding 071002, ChinaCollege of Food Science and Technology, Hebei Agricultural University, Baoding 071002, ChinaCollege of Life Sciences, Institute of Life Sciences and Green Development, Hebei University, Baoding 071002, China; Corresponding author.This study demonstrated the effect of polysaccharides extracted from hawthorn (HPS) on colon tumorigenic mice and investigated to test its mechanism in vivo. Subjects were given daily with HPS at doses of 50, 100 and 200 mg/kg b.w. for 9 weeks, while colon cancer was induced by azoxymethane (AOM) injection and daily administration of 2% (w/v) dextran sulfate sodium (DSS). The results showed that the mice fed with HPS had less colonic weight/length ratio, colonic tumors, inflammatory factors and colonic damage. It was also evidenced that HPS significantly increased apoptosis of colon cancer cells and tissue Caspase-3 levels. In addition, the application of HPS markedly increased the diversity of intestinal microbes and raised the relative abundance of Firmicutes at the phylum level. In conclusion, the study supported that HPS was effective in preventing colon cancer via reducing intestinal inflammation, increasing the rate of apoptosis and maintaining the abundance of intestinal flora.http://www.sciencedirect.com/science/article/pii/S1756464623002189Homogeneous polysaccharideColon cancerHawthorn polysaccharideGut microbiotaAnti-inflammatoryApoptosis |
| spellingShingle | Lei Ma Yumiao Lang Xuelian Xin Wen Zhao Qian Zhou Jie Wang Sijun Dong Polysaccharides extracted from hawthorn (Crataegus pinnatifida) exhibiting protective effects against DSS/AOM-induced colorectal cancer in vivo Journal of Functional Foods Homogeneous polysaccharide Colon cancer Hawthorn polysaccharide Gut microbiota Anti-inflammatory Apoptosis |
| title | Polysaccharides extracted from hawthorn (Crataegus pinnatifida) exhibiting protective effects against DSS/AOM-induced colorectal cancer in vivo |
| title_full | Polysaccharides extracted from hawthorn (Crataegus pinnatifida) exhibiting protective effects against DSS/AOM-induced colorectal cancer in vivo |
| title_fullStr | Polysaccharides extracted from hawthorn (Crataegus pinnatifida) exhibiting protective effects against DSS/AOM-induced colorectal cancer in vivo |
| title_full_unstemmed | Polysaccharides extracted from hawthorn (Crataegus pinnatifida) exhibiting protective effects against DSS/AOM-induced colorectal cancer in vivo |
| title_short | Polysaccharides extracted from hawthorn (Crataegus pinnatifida) exhibiting protective effects against DSS/AOM-induced colorectal cancer in vivo |
| title_sort | polysaccharides extracted from hawthorn crataegus pinnatifida exhibiting protective effects against dss aom induced colorectal cancer in vivo |
| topic | Homogeneous polysaccharide Colon cancer Hawthorn polysaccharide Gut microbiota Anti-inflammatory Apoptosis |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623002189 |
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