Photosensitizers for Photodynamic Therapy of Brain Cancers—A Review
On average, there are about 300,000 new cases of brain cancer each year. Studies have shown that brain and central nervous system tumors are among the top ten causes of death. Due to the extent of this problem and the percentage of patients suffering from brain tumors, innovative therapeutic treatme...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-09-01
|
| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3425/13/9/1299 |
| _version_ | 1797581057055260672 |
|---|---|
| author | Dorota Bartusik-Aebisher Paweł Woźnicki Klaudia Dynarowicz David Aebisher |
| author_facet | Dorota Bartusik-Aebisher Paweł Woźnicki Klaudia Dynarowicz David Aebisher |
| author_sort | Dorota Bartusik-Aebisher |
| collection | DOAJ |
| description | On average, there are about 300,000 new cases of brain cancer each year. Studies have shown that brain and central nervous system tumors are among the top ten causes of death. Due to the extent of this problem and the percentage of patients suffering from brain tumors, innovative therapeutic treatment methods are constantly being sought. One such innovative therapeutic method is photodynamic therapy (PDT). Photodynamic therapy is an alternative and unique technique widely used in dermatology and other fields of medicine for the treatment of oncological and nononcological lesions. Photodynamic therapy consists of the destruction of cancer cells and inducing inflammatory changes by using laser light of a specific wavelength in combination with the application of a photosensitizer. The most commonly used photosensitizers include 5-aminolevulinic acid for the enzymatic generation of protoporphyrin IX, Temoporfin—THPC, Photofrin, Hypericin and Talaporfin. This paper reviews the photosensitizers commonly used in photodynamic therapy for brain tumors. An overview of all three generations of photosensitizers is presented. Along with an indication of the limitations of the treatment of brain tumors, intraoperative photodynamic therapy and its possibilities are described as an alternative therapeutic method. |
| first_indexed | 2024-03-10T22:58:44Z |
| format | Article |
| id | doaj.art-d7dd6d1cf7e146fda3bcdaf4df8eee52 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T22:58:44Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-d7dd6d1cf7e146fda3bcdaf4df8eee522023-11-19T09:49:00ZengMDPI AGBrain Sciences2076-34252023-09-01139129910.3390/brainsci13091299Photosensitizers for Photodynamic Therapy of Brain Cancers—A ReviewDorota Bartusik-Aebisher0Paweł Woźnicki1Klaudia Dynarowicz2David Aebisher3Department of Biochemistry and General Chemistry, Medical College of the University of Rzeszów, 35-959 Rzeszów, PolandStudents English Division Science Club, Medical College of the University of Rzeszów, 35-959 Rzeszów, PolandCenter for Innovative Research in Medical and Natural Sciences, Medical College of the University of Rzeszów, 35-310 Rzeszów, PolandDepartment of Photomedicine and Physical Chemistry, Medical College of the University of Rzeszów, 35-959 Rzeszów, PolandOn average, there are about 300,000 new cases of brain cancer each year. Studies have shown that brain and central nervous system tumors are among the top ten causes of death. Due to the extent of this problem and the percentage of patients suffering from brain tumors, innovative therapeutic treatment methods are constantly being sought. One such innovative therapeutic method is photodynamic therapy (PDT). Photodynamic therapy is an alternative and unique technique widely used in dermatology and other fields of medicine for the treatment of oncological and nononcological lesions. Photodynamic therapy consists of the destruction of cancer cells and inducing inflammatory changes by using laser light of a specific wavelength in combination with the application of a photosensitizer. The most commonly used photosensitizers include 5-aminolevulinic acid for the enzymatic generation of protoporphyrin IX, Temoporfin—THPC, Photofrin, Hypericin and Talaporfin. This paper reviews the photosensitizers commonly used in photodynamic therapy for brain tumors. An overview of all three generations of photosensitizers is presented. Along with an indication of the limitations of the treatment of brain tumors, intraoperative photodynamic therapy and its possibilities are described as an alternative therapeutic method.https://www.mdpi.com/2076-3425/13/9/1299brain cancersphotodynamic therapymolecular targeted therapiesphotosensitizers |
| spellingShingle | Dorota Bartusik-Aebisher Paweł Woźnicki Klaudia Dynarowicz David Aebisher Photosensitizers for Photodynamic Therapy of Brain Cancers—A Review Brain Sciences brain cancers photodynamic therapy molecular targeted therapies photosensitizers |
| title | Photosensitizers for Photodynamic Therapy of Brain Cancers—A Review |
| title_full | Photosensitizers for Photodynamic Therapy of Brain Cancers—A Review |
| title_fullStr | Photosensitizers for Photodynamic Therapy of Brain Cancers—A Review |
| title_full_unstemmed | Photosensitizers for Photodynamic Therapy of Brain Cancers—A Review |
| title_short | Photosensitizers for Photodynamic Therapy of Brain Cancers—A Review |
| title_sort | photosensitizers for photodynamic therapy of brain cancers a review |
| topic | brain cancers photodynamic therapy molecular targeted therapies photosensitizers |
| url | https://www.mdpi.com/2076-3425/13/9/1299 |
| work_keys_str_mv | AT dorotabartusikaebisher photosensitizersforphotodynamictherapyofbraincancersareview AT pawełwoznicki photosensitizersforphotodynamictherapyofbraincancersareview AT klaudiadynarowicz photosensitizersforphotodynamictherapyofbraincancersareview AT davidaebisher photosensitizersforphotodynamictherapyofbraincancersareview |