Identifying HIV-1 Transmission Clusters in Uzbekistan through Analysis of Molecular Surveillance Data
The CRF02_AG and sub-subtype A6 are currently the predominant HIV-1 variants in the Republic of Uzbekistan, but little is known about their time-spatial clustering patterns in high-risk populations. We have applied molecular evolution methods and network analyses to better understand the transmissio...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/8/1675 |
| _version_ | 1797441447598751744 |
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| author | Aleksey Lebedev Anna Kuznetsova Kristina Kim Ekaterina Ozhmegova Anastasiia Antonova Elena Kazennova Aleksandr Tumanov Adkhamjon Mamatkulov Evgeniya Kazakova Nargiz Ibadullaeva Krestina Brigida Erkin Musabaev Dildora Mustafaeva Visola Rakhimova Marina Bobkova |
| author_facet | Aleksey Lebedev Anna Kuznetsova Kristina Kim Ekaterina Ozhmegova Anastasiia Antonova Elena Kazennova Aleksandr Tumanov Adkhamjon Mamatkulov Evgeniya Kazakova Nargiz Ibadullaeva Krestina Brigida Erkin Musabaev Dildora Mustafaeva Visola Rakhimova Marina Bobkova |
| author_sort | Aleksey Lebedev |
| collection | DOAJ |
| description | The CRF02_AG and sub-subtype A6 are currently the predominant HIV-1 variants in the Republic of Uzbekistan, but little is known about their time-spatial clustering patterns in high-risk populations. We have applied molecular evolution methods and network analyses to better understand the transmission patterns of these subtypes by analyzing 316 <i>pol</i> sequences obtained during the surveillance study of HIV drug resistance. Network analysis showed that about one third of the HIV infected persons were organized into clusters, including large clusters with more than 35 members. These clusters were composed mostly of injecting drug users and/or heterosexuals, with women having mainly high centrality within networks identified in both subtypes. Phylogenetic analyses of the ‘Uzbek’ sequences, including those publicly available, show that Russia and Ukraine played a role as the main sources of the current subtype A6 epidemic in the Republic. At the same time, Uzbekistan has been a local center of the CRF02_AG epidemic spread in the former USSR since the early 2000s. Both of these HIV-1 variants continue to spread in Uzbekistan, highlighting the importance of identifying transmission networks and transmission clusters to prevent further HIV spread, and the need for HIV prevention and education campaigns in high-risk groups. |
| first_indexed | 2024-03-09T12:23:11Z |
| format | Article |
| id | doaj.art-d7dd7786df5745c28afd20bfc6728072 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T12:23:11Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-d7dd7786df5745c28afd20bfc67280722023-11-30T22:38:45ZengMDPI AGViruses1999-49152022-07-01148167510.3390/v14081675Identifying HIV-1 Transmission Clusters in Uzbekistan through Analysis of Molecular Surveillance DataAleksey Lebedev0Anna Kuznetsova1Kristina Kim2Ekaterina Ozhmegova3Anastasiia Antonova4Elena Kazennova5Aleksandr Tumanov6Adkhamjon Mamatkulov7Evgeniya Kazakova8Nargiz Ibadullaeva9Krestina Brigida10Erkin Musabaev11Dildora Mustafaeva12Visola Rakhimova13Marina Bobkova14Gamaleya National Research Center for Epidemiology and Microbiology, 123098 Moscow, RussiaGamaleya National Research Center for Epidemiology and Microbiology, 123098 Moscow, RussiaGamaleya National Research Center for Epidemiology and Microbiology, 123098 Moscow, RussiaGamaleya National Research Center for Epidemiology and Microbiology, 123098 Moscow, RussiaGamaleya National Research Center for Epidemiology and Microbiology, 123098 Moscow, RussiaGamaleya National Research Center for Epidemiology and Microbiology, 123098 Moscow, RussiaGamaleya National Research Center for Epidemiology and Microbiology, 123098 Moscow, RussiaResearch Institute of Virology, Tashkent 100194, UzbekistanResearch Institute of Virology, Tashkent 100194, UzbekistanResearch Institute of Virology, Tashkent 100194, UzbekistanResearch Institute of Virology, Tashkent 100194, UzbekistanResearch Institute of Virology, Tashkent 100194, UzbekistanRepublican AIDS Center, The Ministry of Health, Tashkent 100135, UzbekistanCenter for Development of Profession Qualification of Medical Workers, Tashkent 100007, UzbekistanGamaleya National Research Center for Epidemiology and Microbiology, 123098 Moscow, RussiaThe CRF02_AG and sub-subtype A6 are currently the predominant HIV-1 variants in the Republic of Uzbekistan, but little is known about their time-spatial clustering patterns in high-risk populations. We have applied molecular evolution methods and network analyses to better understand the transmission patterns of these subtypes by analyzing 316 <i>pol</i> sequences obtained during the surveillance study of HIV drug resistance. Network analysis showed that about one third of the HIV infected persons were organized into clusters, including large clusters with more than 35 members. These clusters were composed mostly of injecting drug users and/or heterosexuals, with women having mainly high centrality within networks identified in both subtypes. Phylogenetic analyses of the ‘Uzbek’ sequences, including those publicly available, show that Russia and Ukraine played a role as the main sources of the current subtype A6 epidemic in the Republic. At the same time, Uzbekistan has been a local center of the CRF02_AG epidemic spread in the former USSR since the early 2000s. Both of these HIV-1 variants continue to spread in Uzbekistan, highlighting the importance of identifying transmission networks and transmission clusters to prevent further HIV spread, and the need for HIV prevention and education campaigns in high-risk groups.https://www.mdpi.com/1999-4915/14/8/1675HIV-1subtypesmolecular epidemiologytransmission clustersmigration patternsUzbekistan |
| spellingShingle | Aleksey Lebedev Anna Kuznetsova Kristina Kim Ekaterina Ozhmegova Anastasiia Antonova Elena Kazennova Aleksandr Tumanov Adkhamjon Mamatkulov Evgeniya Kazakova Nargiz Ibadullaeva Krestina Brigida Erkin Musabaev Dildora Mustafaeva Visola Rakhimova Marina Bobkova Identifying HIV-1 Transmission Clusters in Uzbekistan through Analysis of Molecular Surveillance Data Viruses HIV-1 subtypes molecular epidemiology transmission clusters migration patterns Uzbekistan |
| title | Identifying HIV-1 Transmission Clusters in Uzbekistan through Analysis of Molecular Surveillance Data |
| title_full | Identifying HIV-1 Transmission Clusters in Uzbekistan through Analysis of Molecular Surveillance Data |
| title_fullStr | Identifying HIV-1 Transmission Clusters in Uzbekistan through Analysis of Molecular Surveillance Data |
| title_full_unstemmed | Identifying HIV-1 Transmission Clusters in Uzbekistan through Analysis of Molecular Surveillance Data |
| title_short | Identifying HIV-1 Transmission Clusters in Uzbekistan through Analysis of Molecular Surveillance Data |
| title_sort | identifying hiv 1 transmission clusters in uzbekistan through analysis of molecular surveillance data |
| topic | HIV-1 subtypes molecular epidemiology transmission clusters migration patterns Uzbekistan |
| url | https://www.mdpi.com/1999-4915/14/8/1675 |
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