Protective Function of Mitogen‐Activated Protein Kinase Phosphatase 5 in Aging‐ and Diet‐Induced Hepatic Steatosis and Steatohepatitis

Protective Function of Mitogen‐Activated Protein Kinase Phosphatase 5 in Aging‐ and Diet‐Induced Hepatic Steatosis and Steatohepatitis

Nonalcoholic fatty liver disease is currently the most common liver disease and is a leading cause of liver‐related morbidity and mortality. However, its pathogenesis remains largely unclear. We previously showed that mice deficient in mitogen‐activated protein kinase (MAPK) phosphatase 5 (MKP5) spo...

Full description

Bibliographic Details
Main Authors:	Peng Tang, Heng Boon Low, Chin Wen Png, Federico Torta, Jaspal Kaur Kumar, Hwee Ying Lim, Yi Zhou, Henry Yang, Veronique Angeli, Asim Shabbir, E. Shyong Tai, Richard A. Flavell, Chen Dong, Markus R. Wenk, Dan Yock Yang, Yongliang Zhang
Format:	Article
Language:	English
Published:	Wolters Kluwer Health/LWW 2019-06-01
Series:	Hepatology Communications
Online Access:	https://doi.org/10.1002/hep4.1324

Similar Items

Is Mitogen‐Activated Protein Kinase Phosphatase 5 a Solution to the Puzzle of the Mitogen‐Activated Protein Kinase Signal in Steatohepatitis?
by: Kouichi Miura, et al.
Published: (2019-06-01)

Steatosis, Steatohepatitis and Cancer Immunotherapy: An Intricate Story
by: Mauro Cataldi, et al.
Published: (2021-11-01)

Hepatic Steatosis and Steatohepatitis Is the Inevitability of Mixed Genesis
by: Yu.M. Stepanov
Published: (2014-11-01)

Differential intrahepatic phospholipid zonation in simple steatosis and nonalcoholic steatohepatitis.
by: Julia Wattacheril, et al.
Published: (2013-01-01)

Integration analysis identifies the role of metallothionein in the progression from hepatic steatosis to steatohepatitis
by: Xiaoya Li, et al.
Published: (2022-10-01)

Mitogen-activated protein kinase phosphatase 1/dual specificity phosphatase 1 mediates glucocorticoid inhibition of osteoblast proliferation.
by: Horsch, K, et al.
Published: (2007)

Proanthocyanidins biotransformed by Saccharomyces cerevisiae prevent the pathogenesis of steatosis and progression to steatohepatitis in vitro
by: Wasitha P.D.W. Thilakarathna, et al.
Published: (2024-01-01)

Mitogen-Activated Protein Kinase Phosphatases (MKPs) in Fungal Signaling: Conservation, Function, and Regulation
by: Gema González-Rubio, et al.
Published: (2019-04-01)

Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38.
by: Lasa, M, et al.
Published: (2002)

Gene expression profiling unravels cancer-related hepatic molecular signatures in steatohepatitis but not in steatosis.
by: Julia Starmann, et al.
Published: (2012-01-01)

Lack of Mitogen-activated Kinase Phosphatase-5 in Macrophages Protects Ldlr-null Mice against Atherogenesis
by: Xinbo Zhang, et al.
Published: (2022-01-01)

Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss
by: Adelaida M Celaya, et al.
Published: (2019-04-01)

SENSITIVITY AND SPECIFICITY OF VECTORCARDIOGRAPHY IN DIAGNOSTICS OF ACUTE MYOCARDIAL INFARCTION COMORBID WITH LIVER STEATOSIS AND NON-ALCOHOLIC STEATOHEPATITIS
by: I. E. Belaya, et al.
Published: (2015-12-01)

β-Hydroxyphosphocarnitine modifies fibrosis, steatosis and improves liver function in non-alcoholic steatohepatitis induced in rats
by: Janet Sánchez-Quevedo, et al.
Published: (2022-09-01)

A role for mitogen-activated protein kinase phosphatase 1 (MKP1) in neural cell development and survival
by: André Toulouse, et al.
Published: (2015-01-01)

Gamma-Muricholic Acid Inhibits Nonalcoholic Steatohepatitis: Abolishment of Steatosis-Dependent Peroxidative Impairment by FXR/SHP/LXRα/FASN Signaling
by: Yang Xie, et al.
Published: (2023-03-01)

Hepatocyte-specific mitogen-activated protein kinase phosphatase 1 in sexual dimorphism and susceptibility to alcohol induced liver injury
by: Mary Nancy Walter, et al.
Published: (2024-02-01)

Mitogen activated protein kinase phosphatase-1 prevents the development of tactile sensitivity in a rodent model of neuropathic pain
by: Ndong Christian, et al.
Published: (2012-04-01)

Are oxidative stress mechanisms the common denominator in the progression from hepatic steatosis towards non-alcoholic steatohepatitis (NASH)?
by: Tariq, Z, et al.
Published: (2014)

Are oxidative stress mechanisms the common denominator in the progression from hepatic steatosis towards non-alcoholic steatohepatitis (NASH)?
by: Tariq, Z, et al.
Published: (2014)

MCD Diet Rat Model Induces Alterations in Zinc and Iron during NAFLD Progression from Steatosis to Steatohepatitis
by: Giuseppina Palladini, et al.
Published: (2022-06-01)

Hepatic transcriptome profiling reveals early signatures associated with disease transition from non-alcoholic steatosis to steatohepatitis
by: Nancy Magee, et al.
Published: (2022-12-01)

Inhibition of Plasminogen Activator Inhibitor 1 Attenuates Hepatic Steatosis but Does Not Prevent Progressive Nonalcoholic Steatohepatitis in Mice
by: Anne S. Henkel, et al.
Published: (2018-12-01)

Non-invasive differentiation of hepatic steatosis and steatohepatitis in a mouse model using nitroxyl radical as an MRI-contrast agent
by: Yuka Yoshino, et al.
Published: (2024-06-01)

Correlation between red cell distribution width and grade of hepatic steatosis and liver enzymes in patients with Non-Alcoholic steatohepatitis
by: Ali Dogan, et al.
Published: (2018-03-01)

Electro-acupuncture reduced steatosis on MRI-PDFF in patients with non-alcoholic steatohepatitis: a randomized controlled pilot clinical trial
by: Jingjie Zhao, et al.
Published: (2023-02-01)

Halted Lymphocyte Egress via Efferent Lymph Contributes to Lymph Node Hypertrophy During Hypercholesterolemia
by: Meng Hwee Daniel Tay, et al.
Published: (2019-03-01)

Inhibition of mitogen-activated protein kinase activity and proliferation of an early osteoblast cell line (MBA 15.4) by dexamethasone: role of protein phosphatases.
by: Hulley, P, et al.
Published: (1998)

Mitogen-activated protein kinase phosphatase 1 controls broad spectrum disease resistance in Arabidopsis thaliana through diverse mechanisms of immune activation
by: Diego José Berlanga, et al.
Published: (2024-03-01)

Mitogen activated protein kinase phosphatase 5 alleviates liver ischemia–reperfusion injury by inhibiting TAK1/JNK/p38 pathway
by: Qiwen Yu, et al.
Published: (2023-07-01)

Mechanism of the mitogenic influence of hyperinsulinemia
by: Draznin Boris
Published: (2011-06-01)

BCI-215, a Dual-Specificity Phosphatase Inhibitor, Reduces UVB-Induced Pigmentation in Human Skin by Activating Mitogen-Activated Protein Kinase Pathways
by: Jeong Hyeon Lee, et al.
Published: (2022-08-01)

Effect of Roselle Flower Extract (<i>Hibiscus sabdariffa</i> Linn.) on Reducing Steatosis and Steatohepatitis in Vitamin B12 Deficiency Rat Model
by: Irena Ujianti, et al.
Published: (2023-05-01)

Liver Steatosis and Steatohepatitis Alter Bile Acid Receptors in Brain and Induce Neuroinflammation: A Contribution of Circulating Bile Acids and Blood-Brain Barrier
by: Noemi Fiaschini, et al.
Published: (2022-11-01)

Regulation of Host Immune Responses against Influenza A Virus Infection by Mitogen-Activated Protein Kinases (MAPKs)
by: Jiabo Yu, et al.
Published: (2020-07-01)

AN1284 attenuates steatosis, lipogenesis, and fibrosis in mice with pre-existing non-alcoholic steatohepatitis and directly affects aryl hydrocarbon receptor in a hepatic cell line
by: Adi S. Yehezkel, et al.
Published: (2023-08-01)

Heteroplasmy and Individual Mitogene Pools: Characteristics and Potential Roles in Ecological Studies
by: Wenhui Wang, et al.
Published: (2023-11-01)

Omalizumab-Associated Steatohepatitis
by: J. Barbosa, et al.
Published: (2023-07-01)

Steatohepatitis in Children with Obesity
by: Alexander A. Zvyagin, et al.
Published: (2021-08-01)

Necroptosis in Nonalcoholic Steatohepatitis
by: Jérémie Gautheron, PhD, et al.
Published: (2015-05-01)