Functional significance of calcium binding to tissue-nonspecific alkaline phosphatase.

Functional significance of calcium binding to tissue-nonspecific alkaline phosphatase.

The conserved active site of alkaline phosphatases (AP) contains catalytically important Zn2+ (M1 and M2) and Mg2+-sites (M3) and a fourth peripheral Ca2+ site (M4) of unknown significance. We have studied Ca2+ binding to M1-4 of tissue-nonspecific AP (TNAP), an enzyme crucial for skeletal mineraliz...

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Bibliographic Details
Main Authors: Marc F Hoylaerts, Soetkin Van Kerckhoven, Tina Kiffer-Moreira, Campbell Sheen, Sonoko Narisawa, José Luis Millán
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4361680?pdf=render

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