Diagnostic yield and variant reassessment in the genes encoding Nav1.5 channel in Russian patients with Brugada syndrome

Diagnostic yield and variant reassessment in the genes encoding Nav1.5 channel in Russian patients with Brugada syndrome

Brugada syndrome (BrS) is an inherited cardiac arrhythmia characterized by ST-elevation, negative T-wave, and a high risk of sudden cardiac death (SCD) due to ventricular tachycardia. It is associated with mutations in over 20 genes but only SCN5A is recommended for routine genetic screening. This s...

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Bibliographic Details
Main Authors: Elena Zaklyazminskaya, Anna Shestak, Dmitry Podolyak, Vera Komoliatova, Leonid Makarov, Anna Novitskaya, Amiran Revishvili
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
SCN5A
Nav1.5 channel
Brugada syndrome comorbidity
Brugada syndrome
cardiac channelopathy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.984299/full

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