The Effect of Electroencephalography Abnormalities on Cerebral Autoregulation in Sedated Ventilated Children
Purpose: To determine the effects of non-ictal electroencephalogram (EEG) changes on cerebrovascular autoregulation (AR) using the cerebral oximetry index (COx). Materials and Methods: Mean arterial blood pressure (MAP), cerebral tissue oxygenation (CrSO2), and EEG were acquired for 96 h. From all o...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Pediatric Reports |
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| Online Access: | https://www.mdpi.com/2036-7503/15/1/2 |
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| author | Madhuradhar Chegondi Wei-Chiang Lin Sayed Naqvi Prithvi Sendi Balagangadhar R. Totapally |
| author_facet | Madhuradhar Chegondi Wei-Chiang Lin Sayed Naqvi Prithvi Sendi Balagangadhar R. Totapally |
| author_sort | Madhuradhar Chegondi |
| collection | DOAJ |
| description | Purpose: To determine the effects of non-ictal electroencephalogram (EEG) changes on cerebrovascular autoregulation (AR) using the cerebral oximetry index (COx). Materials and Methods: Mean arterial blood pressure (MAP), cerebral tissue oxygenation (CrSO2), and EEG were acquired for 96 h. From all of the EEG recordings, 30 min recording segments were extracted using the endotracheal suction events as the guide. EEG recordings were classified as EEG normal and EEG abnormal groups. Each 30 min segment was further divided into six 5 min epochs. Continuous recordings of MAP and CrSO2 by near-infrared spectroscopy (NIRS) were extracted. The COx value was defined as the concordance (R) value of the Pearson correlation between MAP and CrSO2 in a 5 min epoch. Then, an Independent-Samples Mann-Whitney U test was used to analyze the number of epochs within the 30 min segments above various R cutoff values (0.2, 0.3, and 0.4) in normal and abnormal EEG groups. A <i>p</i>-value < 0.05 was considered significant, and all analyses were two-tailed. Results: Among 16 sedated, mechanically ventilated children, 382 EEG recordings of 30 min segments were analyzed. The proportions of epochs in each 30 min segment above the R cutoff values were similar between the EEG normal and EEG abnormal groups (<i>p</i> > 0.05). The median concordance values for CSrO<sub>2</sub> and MAP in EEG normal and EEG abnormal groups were similar (0.26 (0.17–0.35) and 0.18 (0.12–0.31); <i>p</i> = 0.09). Conclusions: Abnormal EEG patterns without ictal changes do not affect cerebrovascular autoregulation in sedated and mechanically ventilated children. |
| first_indexed | 2024-03-11T06:03:38Z |
| format | Article |
| id | doaj.art-d7df482b2063496b9eca363107c17984 |
| institution | Directory Open Access Journal |
| issn | 2036-7503 |
| language | English |
| last_indexed | 2024-03-11T06:03:38Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pediatric Reports |
| spelling | doaj.art-d7df482b2063496b9eca363107c179842023-11-17T13:10:59ZengMDPI AGPediatric Reports2036-75032022-12-0115191510.3390/pediatric15010002The Effect of Electroencephalography Abnormalities on Cerebral Autoregulation in Sedated Ventilated ChildrenMadhuradhar Chegondi0Wei-Chiang Lin1Sayed Naqvi2Prithvi Sendi3Balagangadhar R. Totapally4Division of Critical Care Medicine, Stead Family Children’s Hospital, Iowa City, IA 52242, USADepartment of Biomedical Engineering, Florida International University, Miami, FL 33174, USADepartment of Neurology, Nicklaus Children’s Hospital, Miami, FL 33155, USADivision of Critical Care Medicine, Nicklaus Children’s Hospital, Miami, FL 33155, USADivision of Critical Care Medicine, Nicklaus Children’s Hospital, Miami, FL 33155, USAPurpose: To determine the effects of non-ictal electroencephalogram (EEG) changes on cerebrovascular autoregulation (AR) using the cerebral oximetry index (COx). Materials and Methods: Mean arterial blood pressure (MAP), cerebral tissue oxygenation (CrSO2), and EEG were acquired for 96 h. From all of the EEG recordings, 30 min recording segments were extracted using the endotracheal suction events as the guide. EEG recordings were classified as EEG normal and EEG abnormal groups. Each 30 min segment was further divided into six 5 min epochs. Continuous recordings of MAP and CrSO2 by near-infrared spectroscopy (NIRS) were extracted. The COx value was defined as the concordance (R) value of the Pearson correlation between MAP and CrSO2 in a 5 min epoch. Then, an Independent-Samples Mann-Whitney U test was used to analyze the number of epochs within the 30 min segments above various R cutoff values (0.2, 0.3, and 0.4) in normal and abnormal EEG groups. A <i>p</i>-value < 0.05 was considered significant, and all analyses were two-tailed. Results: Among 16 sedated, mechanically ventilated children, 382 EEG recordings of 30 min segments were analyzed. The proportions of epochs in each 30 min segment above the R cutoff values were similar between the EEG normal and EEG abnormal groups (<i>p</i> > 0.05). The median concordance values for CSrO<sub>2</sub> and MAP in EEG normal and EEG abnormal groups were similar (0.26 (0.17–0.35) and 0.18 (0.12–0.31); <i>p</i> = 0.09). Conclusions: Abnormal EEG patterns without ictal changes do not affect cerebrovascular autoregulation in sedated and mechanically ventilated children.https://www.mdpi.com/2036-7503/15/1/2cerebrovascular autoregulationcerebral oximetry indexEEG changessedativescritically illchildren |
| spellingShingle | Madhuradhar Chegondi Wei-Chiang Lin Sayed Naqvi Prithvi Sendi Balagangadhar R. Totapally The Effect of Electroencephalography Abnormalities on Cerebral Autoregulation in Sedated Ventilated Children Pediatric Reports cerebrovascular autoregulation cerebral oximetry index EEG changes sedatives critically ill children |
| title | The Effect of Electroencephalography Abnormalities on Cerebral Autoregulation in Sedated Ventilated Children |
| title_full | The Effect of Electroencephalography Abnormalities on Cerebral Autoregulation in Sedated Ventilated Children |
| title_fullStr | The Effect of Electroencephalography Abnormalities on Cerebral Autoregulation in Sedated Ventilated Children |
| title_full_unstemmed | The Effect of Electroencephalography Abnormalities on Cerebral Autoregulation in Sedated Ventilated Children |
| title_short | The Effect of Electroencephalography Abnormalities on Cerebral Autoregulation in Sedated Ventilated Children |
| title_sort | effect of electroencephalography abnormalities on cerebral autoregulation in sedated ventilated children |
| topic | cerebrovascular autoregulation cerebral oximetry index EEG changes sedatives critically ill children |
| url | https://www.mdpi.com/2036-7503/15/1/2 |
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