The role of low molecular weight heparin in women with hereditary thrombophilia for good perinatal outcome
The aim of the study was to establish the importance of low molecular weight heparin (LMWH) treatment for good pregnancy outcome in patients with hereditary thrombophilia. This retrospective study included 70 patients with inherited thrombophilia who gave birth at Zagreb University Hospital Center i...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2016-01-01
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| Series: | Acta Clinica Croatica |
| Subjects: | |
| Online Access: | https://hrcak.srce.hr/file/243109 |
| _version_ | 1797207974782959616 |
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| author | Vesna Sokol Marina Ivanišević Mislav Herman Josip Đelmiš |
| author_facet | Vesna Sokol Marina Ivanišević Mislav Herman Josip Đelmiš |
| author_sort | Vesna Sokol |
| collection | DOAJ |
| description | The aim of the study was to establish the importance of low molecular weight heparin (LMWH) treatment for good pregnancy outcome in patients with hereditary thrombophilia. This retrospective study included 70 patients with inherited thrombophilia who gave birth at Zagreb University Hospital Center in the period from January 2014 to January 2015. Fifty-seven women were treated and 13 women were not treated with LMWH. Perinatal outcome was significantly better in women with hereditary thrombophilia who were treated with heparin during pregnancy as compared with women without LMWH (p=0.006). Regardless of heparin therapy, patients with hereditary thrombophilia alone had a significantly better perinatal outcome as compared with women who, along with hereditary thrombophilia, had a history of habitual abortions (p=0.035) or intrauterine fetal death (p=0.033). Women treated with heparin had better perinatal outcome if they were without a history of recurrent or non-recurrent fetal loss (p=0.088). In the group without LMWH, perinatal outcome was significantly better in women with no history of habitual abortions as compared with women with recurrent miscarriages (p=0.047). Administration of LMWH is justified in women with hereditary thrombophilia and a history of adverse perinatal outcome. |
| first_indexed | 2024-04-24T09:31:26Z |
| format | Article |
| id | doaj.art-d7e3377ccdd54d7ab0cc7345ba3026ac |
| institution | Directory Open Access Journal |
| issn | 0353-9466 1333-9451 |
| language | English |
| last_indexed | 2024-04-24T09:31:26Z |
| publishDate | 2016-01-01 |
| publisher | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research |
| record_format | Article |
| series | Acta Clinica Croatica |
| spelling | doaj.art-d7e3377ccdd54d7ab0cc7345ba3026ac2024-04-15T13:55:43ZengSestre Milosrdnice University hospital, Institute of Clinical Medical ResearchActa Clinica Croatica0353-94661333-94512016-01-0155.2.30931510.20471/acc.2016.55.02.19The role of low molecular weight heparin in women with hereditary thrombophilia for good perinatal outcomeVesna Sokol0Marina Ivanišević1Mislav Herman2Josip Đelmiš3Clinical Department of Gynecology and Obstetrics, Zagreb University Hospital Center, Zagreb, CroatiaClinical Department of Gynecology and Obstetrics, Zagreb University Hospital Center, Zagreb, Croatia; University of Zagreb, School of Medicine, Zagreb, CroatiaClinical Department of Gynecology and Obstetrics, Zagreb University Hospital Center, Zagreb, CroatiaUniversity of Zagreb, School of Medicine, Zagreb, CroatiaThe aim of the study was to establish the importance of low molecular weight heparin (LMWH) treatment for good pregnancy outcome in patients with hereditary thrombophilia. This retrospective study included 70 patients with inherited thrombophilia who gave birth at Zagreb University Hospital Center in the period from January 2014 to January 2015. Fifty-seven women were treated and 13 women were not treated with LMWH. Perinatal outcome was significantly better in women with hereditary thrombophilia who were treated with heparin during pregnancy as compared with women without LMWH (p=0.006). Regardless of heparin therapy, patients with hereditary thrombophilia alone had a significantly better perinatal outcome as compared with women who, along with hereditary thrombophilia, had a history of habitual abortions (p=0.035) or intrauterine fetal death (p=0.033). Women treated with heparin had better perinatal outcome if they were without a history of recurrent or non-recurrent fetal loss (p=0.088). In the group without LMWH, perinatal outcome was significantly better in women with no history of habitual abortions as compared with women with recurrent miscarriages (p=0.047). Administration of LMWH is justified in women with hereditary thrombophilia and a history of adverse perinatal outcome.https://hrcak.srce.hr/file/243109Thrombophilia, hereditaryPregnancyHeparin, low-molecular-weightPregnancy outcome |
| spellingShingle | Vesna Sokol Marina Ivanišević Mislav Herman Josip Đelmiš The role of low molecular weight heparin in women with hereditary thrombophilia for good perinatal outcome Acta Clinica Croatica Thrombophilia, hereditary Pregnancy Heparin, low-molecular-weight Pregnancy outcome |
| title | The role of low molecular weight heparin in women with hereditary thrombophilia for good perinatal outcome |
| title_full | The role of low molecular weight heparin in women with hereditary thrombophilia for good perinatal outcome |
| title_fullStr | The role of low molecular weight heparin in women with hereditary thrombophilia for good perinatal outcome |
| title_full_unstemmed | The role of low molecular weight heparin in women with hereditary thrombophilia for good perinatal outcome |
| title_short | The role of low molecular weight heparin in women with hereditary thrombophilia for good perinatal outcome |
| title_sort | role of low molecular weight heparin in women with hereditary thrombophilia for good perinatal outcome |
| topic | Thrombophilia, hereditary Pregnancy Heparin, low-molecular-weight Pregnancy outcome |
| url | https://hrcak.srce.hr/file/243109 |
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