Does antiaggregant administration lead to early diagnosis in proximal colon cancer?
INTRODUCTION[|]Cancers of the proximal colon are often diagnosed in advanced stages with iron deficiency anaemia and nonspecific symptoms. Aspirin and clopidogrel are commonly used antiaggregant agents for various clinical conditions. The aim of this study was to investigate the effects of antiaggre...
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| Format: | Article |
| Language: | English |
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KARE Publishing
2017-08-01
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| Series: | İstanbul Kuzey Klinikleri |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=nci&un=NCI-80148 |
| _version_ | 1828023802735362048 |
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| author | Ulaş Aday Ebubekir Gündeş Hüseyin Çiyiltepe Durmuş Ali Çetin Kamuran Cumhur Değer Selçuk Gülmez Aziz Serkan Senger Emre Bozdağ |
| author_facet | Ulaş Aday Ebubekir Gündeş Hüseyin Çiyiltepe Durmuş Ali Çetin Kamuran Cumhur Değer Selçuk Gülmez Aziz Serkan Senger Emre Bozdağ |
| author_sort | Ulaş Aday |
| collection | DOAJ |
| description | INTRODUCTION[|]Cancers of the proximal colon are often diagnosed in advanced stages with iron deficiency anaemia and nonspecific symptoms. Aspirin and clopidogrel are commonly used antiaggregant agents for various clinical conditions. The aim of this study was to investigate the effects of antiaggregant medication on the early diagnosis of proximal colon cancer.[¤]METHODS[|]We retrospectively reviewed the cases of colon cancer patients who had received curative surgical procedures in our clinic between 1 January 2013 and 31 July 2016. The clinical and pathological results of patients who had used antiaggregant drugs were compared to those who had not.[¤]RESULTS[|]During the studied period, 246 colorectal cancer patients underwent curative surgical procedures. Of the 67 patients with proximal colon cancer who were included in the study, 27 (40.3%) were on antiaggregant medication. The mean age of the antiaggregant group was 67.1 year (34–88 years), while it was 58.3 (34–83 years) for the non-antiaggregant group; the difference between the two was statistically significant (p = 0.03). A pathological evaluation revealed that 74.1% of the antiaggregant group were in the early stages (Stage I/II: 7/13), while 42.5% of the non-antiaggregant group were in the early stages (Stage I–II: 2/15); the difference was statistically significant (p=0.011).[¤]DISCUSSION AND CONCLUSION[|]Antiaggregant medication has a positive effect on diagnosing proximal colon cancer at early-stages. Patients using aspirin or clopidogrel should undergo a complete colonoscopic evaluation in the presence of gastrointestinal tract bleeding or newly developed anaemia.[¤] |
| first_indexed | 2024-04-10T12:34:34Z |
| format | Article |
| id | doaj.art-d7e4bc1e43744ae7b4f4b9020f0a3c7b |
| institution | Directory Open Access Journal |
| issn | 2148-4902 |
| language | English |
| last_indexed | 2024-04-10T12:34:34Z |
| publishDate | 2017-08-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | İstanbul Kuzey Klinikleri |
| spelling | doaj.art-d7e4bc1e43744ae7b4f4b9020f0a3c7b2023-02-15T16:14:44ZengKARE Publishingİstanbul Kuzey Klinikleri2148-49022017-08-014217317910.14744/nci.2017.80148NCI-80148Does antiaggregant administration lead to early diagnosis in proximal colon cancer?Ulaş Aday0Ebubekir Gündeş1Hüseyin Çiyiltepe2Durmuş Ali Çetin3Kamuran Cumhur Değer4Selçuk Gülmez5Aziz Serkan Senger6Emre Bozdağ7Kosuyolu High Speciality Education and Training Hospital, Gastroenterology Surgery,Kartal,İstanbul,TurkeyKosuyolu High Speciality Education and Training Hospital, Gastroenterology Surgery,Kartal,İstanbul,TurkeyKosuyolu High Speciality Education and Training Hospital, Gastroenterology Surgery,Kartal,İstanbul,TurkeyKosuyolu High Speciality Education and Training Hospital, Gastroenterology Surgery,Kartal,İstanbul,TurkeyKosuyolu High Speciality Education and Training Hospital, Gastroenterology Surgery,Kartal,İstanbul,TurkeyKosuyolu High Speciality Education and Training Hospital, Gastroenterology Surgery,Kartal,İstanbul,TurkeyKosuyolu High Speciality Education and Training Hospital, Gastroenterology Surgery,Kartal,İstanbul,TurkeyKosuyolu High Speciality Education and Training Hospital, Gastroenterology Surgery,Kartal,İstanbul,TurkeyINTRODUCTION[|]Cancers of the proximal colon are often diagnosed in advanced stages with iron deficiency anaemia and nonspecific symptoms. Aspirin and clopidogrel are commonly used antiaggregant agents for various clinical conditions. The aim of this study was to investigate the effects of antiaggregant medication on the early diagnosis of proximal colon cancer.[¤]METHODS[|]We retrospectively reviewed the cases of colon cancer patients who had received curative surgical procedures in our clinic between 1 January 2013 and 31 July 2016. The clinical and pathological results of patients who had used antiaggregant drugs were compared to those who had not.[¤]RESULTS[|]During the studied period, 246 colorectal cancer patients underwent curative surgical procedures. Of the 67 patients with proximal colon cancer who were included in the study, 27 (40.3%) were on antiaggregant medication. The mean age of the antiaggregant group was 67.1 year (34–88 years), while it was 58.3 (34–83 years) for the non-antiaggregant group; the difference between the two was statistically significant (p = 0.03). A pathological evaluation revealed that 74.1% of the antiaggregant group were in the early stages (Stage I/II: 7/13), while 42.5% of the non-antiaggregant group were in the early stages (Stage I–II: 2/15); the difference was statistically significant (p=0.011).[¤]DISCUSSION AND CONCLUSION[|]Antiaggregant medication has a positive effect on diagnosing proximal colon cancer at early-stages. Patients using aspirin or clopidogrel should undergo a complete colonoscopic evaluation in the presence of gastrointestinal tract bleeding or newly developed anaemia.[¤]https://jag.journalagent.com/z4/download_fulltext.asp?pdir=nci&un=NCI-80148antiaggregant medicationproximal colon cancerearly-stage |
| spellingShingle | Ulaş Aday Ebubekir Gündeş Hüseyin Çiyiltepe Durmuş Ali Çetin Kamuran Cumhur Değer Selçuk Gülmez Aziz Serkan Senger Emre Bozdağ Does antiaggregant administration lead to early diagnosis in proximal colon cancer? İstanbul Kuzey Klinikleri antiaggregant medication proximal colon cancer early-stage |
| title | Does antiaggregant administration lead to early diagnosis in proximal colon cancer? |
| title_full | Does antiaggregant administration lead to early diagnosis in proximal colon cancer? |
| title_fullStr | Does antiaggregant administration lead to early diagnosis in proximal colon cancer? |
| title_full_unstemmed | Does antiaggregant administration lead to early diagnosis in proximal colon cancer? |
| title_short | Does antiaggregant administration lead to early diagnosis in proximal colon cancer? |
| title_sort | does antiaggregant administration lead to early diagnosis in proximal colon cancer |
| topic | antiaggregant medication proximal colon cancer early-stage |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=nci&un=NCI-80148 |
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