Effects of OLV preconditioning and postconditioning on lung injury in thoracotomy
Objective: To observe the effects of intermittent one-lung ventilation (OLV) before and after surgery on the inflammatory cytokines and biomarkers of oxidative stress in serum of lung cancer patients undergoing open thoracotomy. Methods: Between June 2011 to March 2012, 80 patients undergoing lobect...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2014-04-01
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| Series: | Asian Journal of Surgery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958413000936 |
| _version_ | 1819145156457136128 |
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| author | Yuan-Da Cheng Yang Gao Heng Zhang Chao-Jun Duan Chun-Fang Zhang |
| author_facet | Yuan-Da Cheng Yang Gao Heng Zhang Chao-Jun Duan Chun-Fang Zhang |
| author_sort | Yuan-Da Cheng |
| collection | DOAJ |
| description | Objective: To observe the effects of intermittent one-lung ventilation (OLV) before and after surgery on the inflammatory cytokines and biomarkers of oxidative stress in serum of lung cancer patients undergoing open thoracotomy.
Methods: Between June 2011 to March 2012, 80 patients undergoing lobectomy were classified into four groups nonrandomly: Group A, control group; B, OLV preconditioning group; C, OLV postconditioning group; D, OLV preconditioning-combined-with-postconditioning group. Neutrophil granulocyte (PMN), interleukin 6 (IL-6), superoxide dismutase (SOD), and malondialdehyde (MDA) were assayed in plasma samples taken preoperatively (T1), intraoperatively (T2), and 2 hours postoperatively (T3).
Results: Comparison of T1 with T2 and T3 documented significant increase in MDA, PMN, and IL-6 levels and decrease in SOD in the control group (p < 0.01). Compared with the control group, the levels of IL-6 and MDA decreased and SOD increased significantly at T2 in the OLV preconditioning group, at T3 in the OLV preconditioning combined postconditioning group (p < 0.05).
Conclusion: Preconditioning of intermittent OLV before thoracotomy combined with postconditioning of intermittent returning two-lung ventilation after surgery maybe alleviate systematic inflammatory response and oxidative stress for lung cancer patients. |
| first_indexed | 2024-12-22T12:53:33Z |
| format | Article |
| id | doaj.art-d7e4f1a9d4634c0db070d9fa4d19ec91 |
| institution | Directory Open Access Journal |
| issn | 1015-9584 |
| language | English |
| last_indexed | 2024-12-22T12:53:33Z |
| publishDate | 2014-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj.art-d7e4f1a9d4634c0db070d9fa4d19ec912022-12-21T18:25:11ZengElsevierAsian Journal of Surgery1015-95842014-04-01372808510.1016/j.asjsur.2013.09.003Effects of OLV preconditioning and postconditioning on lung injury in thoracotomyYuan-Da Cheng0Yang Gao1Heng Zhang2Chao-Jun Duan3Chun-Fang Zhang4Department of Cardiothoracic Surgery of Xiangya Hospital, Central South University, Changsha, Hunan, PR ChinaDepartment of Cardiothoracic Surgery of Xiangya Hospital, Central South University, Changsha, Hunan, PR ChinaDepartment of Cardiothoracic Surgery of Xiangya Hospital, Central South University, Changsha, Hunan, PR ChinaMedical Science Institute of Xiangya Hospital, Central South University, Changsha, Hunan, PR ChinaDepartment of Cardiothoracic Surgery of Xiangya Hospital, Central South University, Changsha, Hunan, PR ChinaObjective: To observe the effects of intermittent one-lung ventilation (OLV) before and after surgery on the inflammatory cytokines and biomarkers of oxidative stress in serum of lung cancer patients undergoing open thoracotomy. Methods: Between June 2011 to March 2012, 80 patients undergoing lobectomy were classified into four groups nonrandomly: Group A, control group; B, OLV preconditioning group; C, OLV postconditioning group; D, OLV preconditioning-combined-with-postconditioning group. Neutrophil granulocyte (PMN), interleukin 6 (IL-6), superoxide dismutase (SOD), and malondialdehyde (MDA) were assayed in plasma samples taken preoperatively (T1), intraoperatively (T2), and 2 hours postoperatively (T3). Results: Comparison of T1 with T2 and T3 documented significant increase in MDA, PMN, and IL-6 levels and decrease in SOD in the control group (p < 0.01). Compared with the control group, the levels of IL-6 and MDA decreased and SOD increased significantly at T2 in the OLV preconditioning group, at T3 in the OLV preconditioning combined postconditioning group (p < 0.05). Conclusion: Preconditioning of intermittent OLV before thoracotomy combined with postconditioning of intermittent returning two-lung ventilation after surgery maybe alleviate systematic inflammatory response and oxidative stress for lung cancer patients.http://www.sciencedirect.com/science/article/pii/S1015958413000936acute lung injuryone-lung ventilationoxidative stresspreconditioningpostconditioning |
| spellingShingle | Yuan-Da Cheng Yang Gao Heng Zhang Chao-Jun Duan Chun-Fang Zhang Effects of OLV preconditioning and postconditioning on lung injury in thoracotomy Asian Journal of Surgery acute lung injury one-lung ventilation oxidative stress preconditioning postconditioning |
| title | Effects of OLV preconditioning and postconditioning on lung injury in thoracotomy |
| title_full | Effects of OLV preconditioning and postconditioning on lung injury in thoracotomy |
| title_fullStr | Effects of OLV preconditioning and postconditioning on lung injury in thoracotomy |
| title_full_unstemmed | Effects of OLV preconditioning and postconditioning on lung injury in thoracotomy |
| title_short | Effects of OLV preconditioning and postconditioning on lung injury in thoracotomy |
| title_sort | effects of olv preconditioning and postconditioning on lung injury in thoracotomy |
| topic | acute lung injury one-lung ventilation oxidative stress preconditioning postconditioning |
| url | http://www.sciencedirect.com/science/article/pii/S1015958413000936 |
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