Unraveling the dark matter, long non-coding RNAs, in male reproductive diseases: A narrative review
Recent advances in human transcriptome have revealed the fundamental and functional roles of long non-coding RNA in the susceptibility to diverse diseases and pathological conditions. They participate in wide range of biological processes such as the modulating of chromatin structure, transcription,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Shahid Sadoughi University of Medical Sciences
2020-11-01
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| Series: | International Journal of Reproductive BioMedicine |
| Subjects: | |
| Online Access: | https://doi.org/10.18502/ijrm.v13i11.7959 |
| _version_ | 1818646982435012608 |
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| author | Masoud Dehghan Tezerjani Seyed Mehdi Kalantar |
| author_facet | Masoud Dehghan Tezerjani Seyed Mehdi Kalantar |
| author_sort | Masoud Dehghan Tezerjani |
| collection | DOAJ |
| description | Recent advances in human transcriptome have revealed the fundamental and functional roles of long non-coding RNA in the susceptibility to diverse diseases and pathological conditions. They participate in wide range of biological processes such as the modulating of chromatin structure, transcription, translation, and post-translation modification. In addition, based on their unique expression profiles and their association with clinical abnormalities such as those of related to male reproductive diseases, they can be used to develop therapeutic methods and biomarkers for screening of the diseases. In this study, we will review the identified lncRNAs and their molecular functions in the pathogenesis of male reproductive diseases such as prostate cancer, benign prostatic hyperplasia, prostatitis, testicular cancer, varicocele, and sperm abnormalities. |
| first_indexed | 2024-12-17T00:55:17Z |
| format | Article |
| id | doaj.art-d7e6947ae87c4da490dd29e1d7f90121 |
| institution | Directory Open Access Journal |
| issn | 2476-3772 |
| language | English |
| last_indexed | 2024-12-17T00:55:17Z |
| publishDate | 2020-11-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | International Journal of Reproductive BioMedicine |
| spelling | doaj.art-d7e6947ae87c4da490dd29e1d7f901212022-12-21T22:09:38ZengShahid Sadoughi University of Medical SciencesInternational Journal of Reproductive BioMedicine2476-37722020-11-011892193410.18502/ijrm.v13i11.7959ijrm.v13i11.7959Unraveling the dark matter, long non-coding RNAs, in male reproductive diseases: A narrative reviewMasoud Dehghan Tezerjani0Seyed Mehdi Kalantar1 Department of Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Department of Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Recent advances in human transcriptome have revealed the fundamental and functional roles of long non-coding RNA in the susceptibility to diverse diseases and pathological conditions. They participate in wide range of biological processes such as the modulating of chromatin structure, transcription, translation, and post-translation modification. In addition, based on their unique expression profiles and their association with clinical abnormalities such as those of related to male reproductive diseases, they can be used to develop therapeutic methods and biomarkers for screening of the diseases. In this study, we will review the identified lncRNAs and their molecular functions in the pathogenesis of male reproductive diseases such as prostate cancer, benign prostatic hyperplasia, prostatitis, testicular cancer, varicocele, and sperm abnormalities.https://doi.org/10.18502/ijrm.v13i11.7959long noncoding rna, prostate cancer, prostatic hyperplasia, prostatitis, varicocele, sperm abnormalities. |
| spellingShingle | Masoud Dehghan Tezerjani Seyed Mehdi Kalantar Unraveling the dark matter, long non-coding RNAs, in male reproductive diseases: A narrative review International Journal of Reproductive BioMedicine long noncoding rna, prostate cancer, prostatic hyperplasia, prostatitis, varicocele, sperm abnormalities. |
| title | Unraveling the dark matter, long non-coding RNAs, in male reproductive diseases: A narrative review |
| title_full | Unraveling the dark matter, long non-coding RNAs, in male reproductive diseases: A narrative review |
| title_fullStr | Unraveling the dark matter, long non-coding RNAs, in male reproductive diseases: A narrative review |
| title_full_unstemmed | Unraveling the dark matter, long non-coding RNAs, in male reproductive diseases: A narrative review |
| title_short | Unraveling the dark matter, long non-coding RNAs, in male reproductive diseases: A narrative review |
| title_sort | unraveling the dark matter long non coding rnas in male reproductive diseases a narrative review |
| topic | long noncoding rna, prostate cancer, prostatic hyperplasia, prostatitis, varicocele, sperm abnormalities. |
| url | https://doi.org/10.18502/ijrm.v13i11.7959 |
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