Highways and Detours in the Realm of Photodynamic Therapy
Photodynamic therapy (PDT) has been a topic of interest since the first report in 1900 but has yet to become a ‘mainstream’ treatment protocol in the medical field. There are clear indications for which PDT might be the ‘method of choice’, but it is unlikely that there will be protocols for the trea...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/25/6/3119 |
| _version_ | 1797240781243678720 |
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| author | David Kessel Qian Peng |
| author_facet | David Kessel Qian Peng |
| author_sort | David Kessel |
| collection | DOAJ |
| description | Photodynamic therapy (PDT) has been a topic of interest since the first report in 1900 but has yet to become a ‘mainstream’ treatment protocol in the medical field. There are clear indications for which PDT might be the ‘method of choice’, but it is unlikely that there will be protocols for the treatment of systemic disease. This report discusses recent developments for promoting PDT efficacy, in the context of what is already known. Factors that can limit the scope of these applications are also indicated. Among the more interesting of these developments is the use of formulation techniques to target specific organelles for photodamage. This can enhance responses to PDT and circumvent situations where an impaired death pathway interferes with PDT efficacy. |
| first_indexed | 2024-04-24T18:12:53Z |
| format | Article |
| id | doaj.art-d7ea15a860104d1cbf603daaa7b087e3 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-04-24T18:12:53Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d7ea15a860104d1cbf603daaa7b087e32024-03-27T13:45:04ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-03-01256311910.3390/ijms25063119Highways and Detours in the Realm of Photodynamic TherapyDavid Kessel0Qian Peng1Department of Pharmacology, Wayne State University School of Medicine, 540 E. Canfield Street, Detroit, MI 48201, USADepartment of Pathology, Oslo University Hospital, N-0310 Oslo, NorwayPhotodynamic therapy (PDT) has been a topic of interest since the first report in 1900 but has yet to become a ‘mainstream’ treatment protocol in the medical field. There are clear indications for which PDT might be the ‘method of choice’, but it is unlikely that there will be protocols for the treatment of systemic disease. This report discusses recent developments for promoting PDT efficacy, in the context of what is already known. Factors that can limit the scope of these applications are also indicated. Among the more interesting of these developments is the use of formulation techniques to target specific organelles for photodamage. This can enhance responses to PDT and circumvent situations where an impaired death pathway interferes with PDT efficacy.https://www.mdpi.com/1422-0067/25/6/3119photodynamicphotosensitizationcancer |
| spellingShingle | David Kessel Qian Peng Highways and Detours in the Realm of Photodynamic Therapy International Journal of Molecular Sciences photodynamic photosensitization cancer |
| title | Highways and Detours in the Realm of Photodynamic Therapy |
| title_full | Highways and Detours in the Realm of Photodynamic Therapy |
| title_fullStr | Highways and Detours in the Realm of Photodynamic Therapy |
| title_full_unstemmed | Highways and Detours in the Realm of Photodynamic Therapy |
| title_short | Highways and Detours in the Realm of Photodynamic Therapy |
| title_sort | highways and detours in the realm of photodynamic therapy |
| topic | photodynamic photosensitization cancer |
| url | https://www.mdpi.com/1422-0067/25/6/3119 |
| work_keys_str_mv | AT davidkessel highwaysanddetoursintherealmofphotodynamictherapy AT qianpeng highwaysanddetoursintherealmofphotodynamictherapy |