Feeding with resistant maltodextrin suppresses excessive calorie intake in a high-fat diet, mediated by changes in mouse gut microbiota composition, appetite-related gut hormone secretion, and neuropeptide transcriptional levels
Consuming resistant maltodextrin (RMD) decreases food intake and increase appetite-related gut hormones, but the underlying mechanisms have remained unknown. Therefore, we aimed to elucidate the mechanisms underlying the effects of RMD feeding on food intake (appetite) using Institute of Cancer Rese...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Microbiomes |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/frmbi.2023.1149808/full |
| _version_ | 1797843272106770432 |
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| author | Kaede Ito Atsushi Haraguchi Shuhei Sato Masataka Sekiguchi Hiroyuki Sasaki Conn Ryan Yijin Lyu Shigenobu Shibata |
| author_facet | Kaede Ito Atsushi Haraguchi Shuhei Sato Masataka Sekiguchi Hiroyuki Sasaki Conn Ryan Yijin Lyu Shigenobu Shibata |
| author_sort | Kaede Ito |
| collection | DOAJ |
| description | Consuming resistant maltodextrin (RMD) decreases food intake and increase appetite-related gut hormones, but the underlying mechanisms have remained unknown. Therefore, we aimed to elucidate the mechanisms underlying the effects of RMD feeding on food intake (appetite) using Institute of Cancer Research male mice fed with a high-fat diet (HFD-cellulose group) or HFD in which cellulose was replaced with RMD (HFD-RMD group). Feeding mice with an HFD-RMD for approximately 8 weeks inhibited excessive calorie intake and altered the gut microbiota composition. Excessive calorie intake was inhibited for several days in mice fed only with an HFD-cellulose and transplanted with fecal microbiota from the HFD-RMD group (FMT-HFD-RMD group). Moreover, in the HFD-RMD and FMT-HFD-RMD groups, serum active glucagon-like peptide (GLP)-1 and peptide tyrosine tyrosine (PYY) levels were significantly higher, and appetite-related neuropeptide gene transcription in the hypothalamus were significantly altered, compared with the HFD-cellulose and FMT-HFD-cellulose groups. These results suggested that the long-term RMD intake changed the gut microbiota composition, increased the GLP-1 and PYY secretion, and altered the appetite-related neuropeptide gene transcription in the hypothalamus, leading to suppressed excessive calorie intake in an HFD. |
| first_indexed | 2024-04-09T17:02:28Z |
| format | Article |
| id | doaj.art-d7ebe1f6157a4f538eaa330a2f7765a4 |
| institution | Directory Open Access Journal |
| issn | 2813-4338 |
| language | English |
| last_indexed | 2024-04-09T17:02:28Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiomes |
| spelling | doaj.art-d7ebe1f6157a4f538eaa330a2f7765a42023-04-21T04:39:03ZengFrontiers Media S.A.Frontiers in Microbiomes2813-43382023-04-01210.3389/frmbi.2023.11498081149808Feeding with resistant maltodextrin suppresses excessive calorie intake in a high-fat diet, mediated by changes in mouse gut microbiota composition, appetite-related gut hormone secretion, and neuropeptide transcriptional levelsKaede ItoAtsushi HaraguchiShuhei SatoMasataka SekiguchiHiroyuki SasakiConn RyanYijin LyuShigenobu ShibataConsuming resistant maltodextrin (RMD) decreases food intake and increase appetite-related gut hormones, but the underlying mechanisms have remained unknown. Therefore, we aimed to elucidate the mechanisms underlying the effects of RMD feeding on food intake (appetite) using Institute of Cancer Research male mice fed with a high-fat diet (HFD-cellulose group) or HFD in which cellulose was replaced with RMD (HFD-RMD group). Feeding mice with an HFD-RMD for approximately 8 weeks inhibited excessive calorie intake and altered the gut microbiota composition. Excessive calorie intake was inhibited for several days in mice fed only with an HFD-cellulose and transplanted with fecal microbiota from the HFD-RMD group (FMT-HFD-RMD group). Moreover, in the HFD-RMD and FMT-HFD-RMD groups, serum active glucagon-like peptide (GLP)-1 and peptide tyrosine tyrosine (PYY) levels were significantly higher, and appetite-related neuropeptide gene transcription in the hypothalamus were significantly altered, compared with the HFD-cellulose and FMT-HFD-cellulose groups. These results suggested that the long-term RMD intake changed the gut microbiota composition, increased the GLP-1 and PYY secretion, and altered the appetite-related neuropeptide gene transcription in the hypothalamus, leading to suppressed excessive calorie intake in an HFD.https://www.frontiersin.org/articles/10.3389/frmbi.2023.1149808/fullgut microbiota compositionappetite and food intakeappetite-related gut hormonesappetite-related neuropeptidesfecal microbiota transplantation (FMT)resistant maltodextrin |
| spellingShingle | Kaede Ito Atsushi Haraguchi Shuhei Sato Masataka Sekiguchi Hiroyuki Sasaki Conn Ryan Yijin Lyu Shigenobu Shibata Feeding with resistant maltodextrin suppresses excessive calorie intake in a high-fat diet, mediated by changes in mouse gut microbiota composition, appetite-related gut hormone secretion, and neuropeptide transcriptional levels Frontiers in Microbiomes gut microbiota composition appetite and food intake appetite-related gut hormones appetite-related neuropeptides fecal microbiota transplantation (FMT) resistant maltodextrin |
| title | Feeding with resistant maltodextrin suppresses excessive calorie intake in a high-fat diet, mediated by changes in mouse gut microbiota composition, appetite-related gut hormone secretion, and neuropeptide transcriptional levels |
| title_full | Feeding with resistant maltodextrin suppresses excessive calorie intake in a high-fat diet, mediated by changes in mouse gut microbiota composition, appetite-related gut hormone secretion, and neuropeptide transcriptional levels |
| title_fullStr | Feeding with resistant maltodextrin suppresses excessive calorie intake in a high-fat diet, mediated by changes in mouse gut microbiota composition, appetite-related gut hormone secretion, and neuropeptide transcriptional levels |
| title_full_unstemmed | Feeding with resistant maltodextrin suppresses excessive calorie intake in a high-fat diet, mediated by changes in mouse gut microbiota composition, appetite-related gut hormone secretion, and neuropeptide transcriptional levels |
| title_short | Feeding with resistant maltodextrin suppresses excessive calorie intake in a high-fat diet, mediated by changes in mouse gut microbiota composition, appetite-related gut hormone secretion, and neuropeptide transcriptional levels |
| title_sort | feeding with resistant maltodextrin suppresses excessive calorie intake in a high fat diet mediated by changes in mouse gut microbiota composition appetite related gut hormone secretion and neuropeptide transcriptional levels |
| topic | gut microbiota composition appetite and food intake appetite-related gut hormones appetite-related neuropeptides fecal microbiota transplantation (FMT) resistant maltodextrin |
| url | https://www.frontiersin.org/articles/10.3389/frmbi.2023.1149808/full |
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