Comparison of Cell Fusions Induced by Influenza Virus and SARS-CoV-2
Virus–cell fusion is the key step for viral infection in host cells. Studies on virus binding and fusion with host cells are important for understanding the virus–host interaction and viral pathogenesis for the discovery of antiviral drugs. In this review, we focus on the virus–cell fusions induced...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-07-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/13/7365 |
| _version_ | 1797479619227549696 |
|---|---|
| author | Chuyuan Zhang Xinjie Meng Hanjun Zhao |
| author_facet | Chuyuan Zhang Xinjie Meng Hanjun Zhao |
| author_sort | Chuyuan Zhang |
| collection | DOAJ |
| description | Virus–cell fusion is the key step for viral infection in host cells. Studies on virus binding and fusion with host cells are important for understanding the virus–host interaction and viral pathogenesis for the discovery of antiviral drugs. In this review, we focus on the virus–cell fusions induced by the two major pandemic viruses, including the influenza virus and SARS-CoV-2. We further compare the cell fusions induced by the influenza virus and SARS-CoV-2, especially the pH-dependent fusion of the influenza virus and the fusion of SARS-CoV-2 in the type-II transmembrane serine protease 2 negative (TMPRSS2<sup>-</sup>) cells with syncytia formation. Finally, we present the development of drugs used against SARA-CoV-2 and the influenza virus through the discovery of anti-fusion drugs and the prevention of pandemic respiratory viruses. |
| first_indexed | 2024-03-09T21:48:24Z |
| format | Article |
| id | doaj.art-d7ee5ce73920478883e14b3c3798f5d6 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:48:24Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d7ee5ce73920478883e14b3c3798f5d62023-11-23T20:12:33ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-07-012313736510.3390/ijms23137365Comparison of Cell Fusions Induced by Influenza Virus and SARS-CoV-2Chuyuan Zhang0Xinjie Meng1Hanjun Zhao2Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaDepartment of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaDepartment of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaVirus–cell fusion is the key step for viral infection in host cells. Studies on virus binding and fusion with host cells are important for understanding the virus–host interaction and viral pathogenesis for the discovery of antiviral drugs. In this review, we focus on the virus–cell fusions induced by the two major pandemic viruses, including the influenza virus and SARS-CoV-2. We further compare the cell fusions induced by the influenza virus and SARS-CoV-2, especially the pH-dependent fusion of the influenza virus and the fusion of SARS-CoV-2 in the type-II transmembrane serine protease 2 negative (TMPRSS2<sup>-</sup>) cells with syncytia formation. Finally, we present the development of drugs used against SARA-CoV-2 and the influenza virus through the discovery of anti-fusion drugs and the prevention of pandemic respiratory viruses.https://www.mdpi.com/1422-0067/23/13/7365cell fusionsfusion inhibitorsinfluenza virusSARS-CoV-2 |
| spellingShingle | Chuyuan Zhang Xinjie Meng Hanjun Zhao Comparison of Cell Fusions Induced by Influenza Virus and SARS-CoV-2 International Journal of Molecular Sciences cell fusions fusion inhibitors influenza virus SARS-CoV-2 |
| title | Comparison of Cell Fusions Induced by Influenza Virus and SARS-CoV-2 |
| title_full | Comparison of Cell Fusions Induced by Influenza Virus and SARS-CoV-2 |
| title_fullStr | Comparison of Cell Fusions Induced by Influenza Virus and SARS-CoV-2 |
| title_full_unstemmed | Comparison of Cell Fusions Induced by Influenza Virus and SARS-CoV-2 |
| title_short | Comparison of Cell Fusions Induced by Influenza Virus and SARS-CoV-2 |
| title_sort | comparison of cell fusions induced by influenza virus and sars cov 2 |
| topic | cell fusions fusion inhibitors influenza virus SARS-CoV-2 |
| url | https://www.mdpi.com/1422-0067/23/13/7365 |
| work_keys_str_mv | AT chuyuanzhang comparisonofcellfusionsinducedbyinfluenzavirusandsarscov2 AT xinjiemeng comparisonofcellfusionsinducedbyinfluenzavirusandsarscov2 AT hanjunzhao comparisonofcellfusionsinducedbyinfluenzavirusandsarscov2 |