Major mistakes and errors in the use of Trial Sequential Analysis in systematic reviews or meta-analyses – protocol for a systematic review

Major mistakes and errors in the use of Trial Sequential Analysis in systematic reviews or meta-analyses – protocol for a systematic review

Abstract Background Adequately conducted systematic reviews with meta-analyses are considered the highest level of evidence and thus directly defines many clinical guidelines. However, the risks of type I and II errors in meta-analyses are substantial. Trial Sequential Analysis is a method for contr...

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Bibliographic Details
Main Authors: Christian Gunge Riberholt, Markus Harboe Olsen, Joachim Birch Milan, Christian Gluud
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Systematic Reviews
Subjects:
Meta analysis
Methodology
Systematic review
Trial Sequential Analysis
Online Access:https://doi.org/10.1186/s13643-022-01987-4

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