Drug-loaded microbubble delivery system to enhance PD-L1 blockade immunotherapy with remodeling immune microenvironment

Drug-loaded microbubble delivery system to enhance PD-L1 blockade immunotherapy with remodeling immune microenvironment

Abstract Background Although programmed cell death protein 1 (PD-1)/ programmed cell death-ligand protein 1 (PD-L1) checkpoint blockade immunotherapy demonstrates great promise in cancer treatment, poor infiltration of T cells resulted from tumor immunosuppressive microenvironment (TIME) and insuffi...

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Bibliographic Details
Main Authors: Jun Zheng, Ju Huang, Liang Zhang, Mengna Wang, Lihong Xu, Xiaoyun Dou, Xiaojing Leng, Mingxiao Fang, Yang Sun, Zhigang Wang
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2023-02-01
Series:Biomaterials Research
Subjects:
Ultrasound-targeted microbubble destruction (UTMD)
Immune checkpoint blockade (ICB)
Docetaxel (DTX)
PD-L1
Tumor immunosuppressive microenvironment
Online Access:https://doi.org/10.1186/s40824-023-00350-5

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