Attenuation of soft-tissue sarcomas resistance to the cytotoxic action of TNF-α by restoring p53 function.

Attenuation of soft-tissue sarcomas resistance to the cytotoxic action of TNF-α by restoring p53 function.

<h4>Background</h4>Isolated limb perfusion with TNF-α and melphalan is used with remarkable efficiency to treat unresectable limb sarcomas. Here we tested the ability of TNF-α to directly induce apoptosis of sarcoma cells. In addition, we investigated the impact of p53 in the regulation...

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Main Authors: Jane Muret, Meriem Hasmim, Izabela Stasik, Abdelali Jalil, Aude Mallavialle, Arash Nanbakhsh, Ludovic Lacroix, Katy Billot, Véronique Baud, Jérome Thiery, Philippe Vielh, Philippe Terrier, Joelle Wiels, Lyubomir Vassilev, Axel Lecesne, Sylvie Bonvalot, Salem Chouaib
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22719951/?tool=EBI

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