Predictive factors of unfavorable prostate cancer in patients who underwent prostatectomy but eligible for active surveillance
To investigate the predictive factors of unfavorable prostate cancer in Korean men who underwent radical prostatectomy but eligible for active surveillance according to Epstein criteria. Methods: We retrospectively reviewed the medical records of 2,036 patients who underwent radical prostatectomy fo...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2014-06-01
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| Series: | Prostate International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2287888215300507 |
| _version_ | 1797713985085112320 |
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| author | Seol Ho Choo Hwang Gyun Jeon Byong Chang Jeong Seong Il Seo Seong Soo Jeon Han Yong Choi Hyun Moo Lee |
| author_facet | Seol Ho Choo Hwang Gyun Jeon Byong Chang Jeong Seong Il Seo Seong Soo Jeon Han Yong Choi Hyun Moo Lee |
| author_sort | Seol Ho Choo |
| collection | DOAJ |
| description | To investigate the predictive factors of unfavorable prostate cancer in Korean men who underwent radical prostatectomy but eligible for active surveillance according to Epstein criteria.
Methods: We retrospectively reviewed the medical records of 2,036 patients who underwent radical prostatectomy for prostate cancer between 1994 and 2011. Among these, 233 patients were eligible for active surveillance based on Epstein criteria. Unfavorable prostate cancer was defined as pathologic Gleason sum ≥7 or non–organ-confined disease. We investigated pathologic outcomes and predictive factors for unfavorable prostate cancer.
Results: Of 233 cases, 91 patients (39.1%) were pathologic Gleason sum ≥7, 11 (4.7%) had extracapsular extension, and three (1.3%) had seminal vesicle invasion. Ninety-eight patients (42.1%) had unfavorable prostate cancer. When comparing clinically insignificant and significant prostate cancer, there were significant differences in mean age (P=0.007), prostate volume (P=0.021), prostate-specific antigen (PSA) density (P=0.03), maximum tumor volume in biopsy core (P<0.001), and rate of two positive cores (P=0.001). On multivariate analysis, age (P=0.015), PSA density (P=0.017) and two positive cores (P=0.001) were independent predictive factors for unfavorable prostate cancer.
Conclusions: A significant proportion of patients who were candidates for active surveillance had unfavorable prostate cancer. Age, PSA density, and two positive cores were independent significant predictive factors for unfavorable prostate cancer. These factors should be considered when performing active surveillance. |
| first_indexed | 2024-03-12T07:45:19Z |
| format | Article |
| id | doaj.art-d7f507b2e7cb4bb68eb4affacbfe5143 |
| institution | Directory Open Access Journal |
| issn | 2287-8882 |
| language | English |
| last_indexed | 2024-03-12T07:45:19Z |
| publishDate | 2014-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Prostate International |
| spelling | doaj.art-d7f507b2e7cb4bb68eb4affacbfe51432023-09-02T21:03:07ZengElsevierProstate International2287-88822014-06-0122707510.12954/PI.14042Predictive factors of unfavorable prostate cancer in patients who underwent prostatectomy but eligible for active surveillanceSeol Ho ChooHwang Gyun JeonByong Chang JeongSeong Il SeoSeong Soo JeonHan Yong ChoiHyun Moo LeeTo investigate the predictive factors of unfavorable prostate cancer in Korean men who underwent radical prostatectomy but eligible for active surveillance according to Epstein criteria. Methods: We retrospectively reviewed the medical records of 2,036 patients who underwent radical prostatectomy for prostate cancer between 1994 and 2011. Among these, 233 patients were eligible for active surveillance based on Epstein criteria. Unfavorable prostate cancer was defined as pathologic Gleason sum ≥7 or non–organ-confined disease. We investigated pathologic outcomes and predictive factors for unfavorable prostate cancer. Results: Of 233 cases, 91 patients (39.1%) were pathologic Gleason sum ≥7, 11 (4.7%) had extracapsular extension, and three (1.3%) had seminal vesicle invasion. Ninety-eight patients (42.1%) had unfavorable prostate cancer. When comparing clinically insignificant and significant prostate cancer, there were significant differences in mean age (P=0.007), prostate volume (P=0.021), prostate-specific antigen (PSA) density (P=0.03), maximum tumor volume in biopsy core (P<0.001), and rate of two positive cores (P=0.001). On multivariate analysis, age (P=0.015), PSA density (P=0.017) and two positive cores (P=0.001) were independent predictive factors for unfavorable prostate cancer. Conclusions: A significant proportion of patients who were candidates for active surveillance had unfavorable prostate cancer. Age, PSA density, and two positive cores were independent significant predictive factors for unfavorable prostate cancer. These factors should be considered when performing active surveillance.http://www.sciencedirect.com/science/article/pii/S2287888215300507Prostatic neoplasmsSurveillanceProstatectomyPathologyNeoplasm grading |
| spellingShingle | Seol Ho Choo Hwang Gyun Jeon Byong Chang Jeong Seong Il Seo Seong Soo Jeon Han Yong Choi Hyun Moo Lee Predictive factors of unfavorable prostate cancer in patients who underwent prostatectomy but eligible for active surveillance Prostate International Prostatic neoplasms Surveillance Prostatectomy Pathology Neoplasm grading |
| title | Predictive factors of unfavorable prostate cancer in patients who underwent prostatectomy but eligible for active surveillance |
| title_full | Predictive factors of unfavorable prostate cancer in patients who underwent prostatectomy but eligible for active surveillance |
| title_fullStr | Predictive factors of unfavorable prostate cancer in patients who underwent prostatectomy but eligible for active surveillance |
| title_full_unstemmed | Predictive factors of unfavorable prostate cancer in patients who underwent prostatectomy but eligible for active surveillance |
| title_short | Predictive factors of unfavorable prostate cancer in patients who underwent prostatectomy but eligible for active surveillance |
| title_sort | predictive factors of unfavorable prostate cancer in patients who underwent prostatectomy but eligible for active surveillance |
| topic | Prostatic neoplasms Surveillance Prostatectomy Pathology Neoplasm grading |
| url | http://www.sciencedirect.com/science/article/pii/S2287888215300507 |
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