When membranes need an ESCRT: endosomal sorting and membrane remodelling in health and disease
Originally discovered as regulators of cargo sorting during endosomal trafficking, ESCRT (endosomal sorting complexes required for transport) proteins are emerging as flexible machines that shape the behaviour of membranes throughout the cell. Deregulation of ESCRT activity is observed in neuro-de...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
SMW supporting association (Trägerverein Swiss Medical Weekly SMW)
2016-09-01
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| Series: | Swiss Medical Weekly |
| Subjects: | |
| Online Access: | https://www.smw.ch/index.php/smw/article/view/2219 |
| _version_ | 1798003782557106176 |
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| author | Victor Alfred Thomas Vaccari |
| author_facet | Victor Alfred Thomas Vaccari |
| author_sort | Victor Alfred |
| collection | DOAJ |
| description |
Originally discovered as regulators of cargo sorting during endosomal trafficking, ESCRT (endosomal sorting complexes required for transport) proteins are emerging as flexible machines that shape the behaviour of membranes throughout the cell. Deregulation of ESCRT activity is observed in neuro-degenerative diseases, virus infection and cancer. However, the mechanisms of pathogenesis involving ESCRTs have not yet fully come into focus. Here, we review the current knowledge of ESCRT function in health and disease and provide educated guesses for future research and focused therapeutic intervention.
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| first_indexed | 2024-04-11T12:13:20Z |
| format | Article |
| id | doaj.art-d7f7931d1b804bdfb12f6e9fef71a5c1 |
| institution | Directory Open Access Journal |
| issn | 1424-3997 |
| language | English |
| last_indexed | 2024-04-11T12:13:20Z |
| publishDate | 2016-09-01 |
| publisher | SMW supporting association (Trägerverein Swiss Medical Weekly SMW) |
| record_format | Article |
| series | Swiss Medical Weekly |
| spelling | doaj.art-d7f7931d1b804bdfb12f6e9fef71a5c12022-12-22T04:24:32ZengSMW supporting association (Trägerverein Swiss Medical Weekly SMW)Swiss Medical Weekly1424-39972016-09-01146373810.4414/smw.2016.14347When membranes need an ESCRT: endosomal sorting and membrane remodelling in health and diseaseVictor AlfredThomas Vaccari Originally discovered as regulators of cargo sorting during endosomal trafficking, ESCRT (endosomal sorting complexes required for transport) proteins are emerging as flexible machines that shape the behaviour of membranes throughout the cell. Deregulation of ESCRT activity is observed in neuro-degenerative diseases, virus infection and cancer. However, the mechanisms of pathogenesis involving ESCRTs have not yet fully come into focus. Here, we review the current knowledge of ESCRT function in health and disease and provide educated guesses for future research and focused therapeutic intervention. https://www.smw.ch/index.php/smw/article/view/2219CancerEndosomal sortingESCRTMembrane remodelingMVB biogenesisneurodegeneration |
| spellingShingle | Victor Alfred Thomas Vaccari When membranes need an ESCRT: endosomal sorting and membrane remodelling in health and disease Swiss Medical Weekly Cancer Endosomal sorting ESCRT Membrane remodeling MVB biogenesis neurodegeneration |
| title | When membranes need an ESCRT: endosomal sorting and membrane remodelling in health and disease |
| title_full | When membranes need an ESCRT: endosomal sorting and membrane remodelling in health and disease |
| title_fullStr | When membranes need an ESCRT: endosomal sorting and membrane remodelling in health and disease |
| title_full_unstemmed | When membranes need an ESCRT: endosomal sorting and membrane remodelling in health and disease |
| title_short | When membranes need an ESCRT: endosomal sorting and membrane remodelling in health and disease |
| title_sort | when membranes need an escrt endosomal sorting and membrane remodelling in health and disease |
| topic | Cancer Endosomal sorting ESCRT Membrane remodeling MVB biogenesis neurodegeneration |
| url | https://www.smw.ch/index.php/smw/article/view/2219 |
| work_keys_str_mv | AT victoralfred whenmembranesneedanescrtendosomalsortingandmembraneremodellinginhealthanddisease AT thomasvaccari whenmembranesneedanescrtendosomalsortingandmembraneremodellinginhealthanddisease |