Meta-Analysis of Cardiovascular Risk Factors in Offspring of Preeclampsia Pregnancies
This study aimed to assess cardiovascular risk factors in the offspring of preeclampsia (PE) pregnancies. PubMed, Web of Science, Ovid, and other foreign language databases, as well as SinoMed, China National Knowledge Infrastructure, Wanfang, and China Science and Technology Journal Databases, were...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/13/4/812 |
| _version_ | 1797621467236532224 |
|---|---|
| author | Weikai Wang Ru Lin Lan Yang Yanxia Wang Baohong Mao Xiaoying Xu Jing Yu |
| author_facet | Weikai Wang Ru Lin Lan Yang Yanxia Wang Baohong Mao Xiaoying Xu Jing Yu |
| author_sort | Weikai Wang |
| collection | DOAJ |
| description | This study aimed to assess cardiovascular risk factors in the offspring of preeclampsia (PE) pregnancies. PubMed, Web of Science, Ovid, and other foreign language databases, as well as SinoMed, China National Knowledge Infrastructure, Wanfang, and China Science and Technology Journal Databases, were searched. The case-control studies on cardiovascular risk factors in the offspring of PE pregnancies from 1 January 2010 to 31 December 2019 were collected. A random-effects model or a fixed-effects model was used, and RevMan 5.3 software was used for meta-analysis to determine the OR value and 95%CI of each cardiovascular risk factor. A total of 16 documents were included in this research, all of which were case-control studies, with a total of 4046 cases in the experimental group and 31,505 in the control group. The meta-analysis that was conducted demonstrated that SBP [MD = 1.51, 95%CI (1.15, 1.88)] and DBP [MD = 1.90, 95%CI (1.69, 2.10)] values in the PE pregnancy offspring group presented an elevation relative to the non-PE pregnancy offspring group. The total cholesterol value in the PE pregnancy offspring group presented an elevation relative to the non-PE pregnancy offspring group [MD = 0.11, 95%CI (0.08, 0.13)]. The low-density lipoprotein cholesterol value in the PE pregnancy offspring group was comparable to that in the non-PE pregnancy offspring group [MD = 0.01, 95%CI (−0.02, 0.05)]. The high-density lipoprotein cholesterol value in the PE pregnancy offspring group presented an elevation relative to the non-PE pregnancy offspring group [MD = 0.02, 95%CI (0.01, 0.03)]. The non-HDL cholesterol value in the PE pregnancy offspring group presented an elevation relative to the non-PE pregnancy offspring group [MD = 0.16, 95%CI (0.13, 0.19)]. The triglycerides [MD = −0.02, 95%CI (−0.03, −0.01)] and glucose [MD = −0.08, 95%CI (−0.09, −0.07)] values in the PE pregnancy offspring group presented a depletion relative to the non-PE pregnancy group. The insulin value in the PE pregnancy offspring group presented a depletion relative to the non-PE pregnancy offspring group [MD = −0.21, 95%CI (−0.32, −0.09)]. The BMI value in the PE pregnancy offspring group presented an elevation relative to the non-PE pregnancy offspring group [MD = 0.42, 95%CI (0.27, 0.57)]. In conclusion, dyslipidemia, elevated blood pressure, and increased BMI occur postpartum with PE, all of which are risk factors for cardiovascular diseases. |
| first_indexed | 2024-03-11T08:57:23Z |
| format | Article |
| id | doaj.art-d7f7ee1438524d458b3e70aa3b6c5b53 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T08:57:23Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-d7f7ee1438524d458b3e70aa3b6c5b532023-11-16T20:03:20ZengMDPI AGDiagnostics2075-44182023-02-0113481210.3390/diagnostics13040812Meta-Analysis of Cardiovascular Risk Factors in Offspring of Preeclampsia PregnanciesWeikai Wang0Ru Lin1Lan Yang2Yanxia Wang3Baohong Mao4Xiaoying Xu5Jing Yu6The Second School of Clinical Medicine, Lanzhou University, Lanzhou 730000, ChinaEndoscopy Center, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou 730000, ChinaDepartment of PICU, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou 730000, ChinaScientific Research Center, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou 730000, ChinaScientific Research Center, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou 730000, ChinaPerinatal Medical Center, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou 730000, ChinaHypertension Center, The Second Hospital of Lanzhou University, Lanzhou 730000, ChinaThis study aimed to assess cardiovascular risk factors in the offspring of preeclampsia (PE) pregnancies. PubMed, Web of Science, Ovid, and other foreign language databases, as well as SinoMed, China National Knowledge Infrastructure, Wanfang, and China Science and Technology Journal Databases, were searched. The case-control studies on cardiovascular risk factors in the offspring of PE pregnancies from 1 January 2010 to 31 December 2019 were collected. A random-effects model or a fixed-effects model was used, and RevMan 5.3 software was used for meta-analysis to determine the OR value and 95%CI of each cardiovascular risk factor. A total of 16 documents were included in this research, all of which were case-control studies, with a total of 4046 cases in the experimental group and 31,505 in the control group. The meta-analysis that was conducted demonstrated that SBP [MD = 1.51, 95%CI (1.15, 1.88)] and DBP [MD = 1.90, 95%CI (1.69, 2.10)] values in the PE pregnancy offspring group presented an elevation relative to the non-PE pregnancy offspring group. The total cholesterol value in the PE pregnancy offspring group presented an elevation relative to the non-PE pregnancy offspring group [MD = 0.11, 95%CI (0.08, 0.13)]. The low-density lipoprotein cholesterol value in the PE pregnancy offspring group was comparable to that in the non-PE pregnancy offspring group [MD = 0.01, 95%CI (−0.02, 0.05)]. The high-density lipoprotein cholesterol value in the PE pregnancy offspring group presented an elevation relative to the non-PE pregnancy offspring group [MD = 0.02, 95%CI (0.01, 0.03)]. The non-HDL cholesterol value in the PE pregnancy offspring group presented an elevation relative to the non-PE pregnancy offspring group [MD = 0.16, 95%CI (0.13, 0.19)]. The triglycerides [MD = −0.02, 95%CI (−0.03, −0.01)] and glucose [MD = −0.08, 95%CI (−0.09, −0.07)] values in the PE pregnancy offspring group presented a depletion relative to the non-PE pregnancy group. The insulin value in the PE pregnancy offspring group presented a depletion relative to the non-PE pregnancy offspring group [MD = −0.21, 95%CI (−0.32, −0.09)]. The BMI value in the PE pregnancy offspring group presented an elevation relative to the non-PE pregnancy offspring group [MD = 0.42, 95%CI (0.27, 0.57)]. In conclusion, dyslipidemia, elevated blood pressure, and increased BMI occur postpartum with PE, all of which are risk factors for cardiovascular diseases.https://www.mdpi.com/2075-4418/13/4/812preeclampsiapregnancy offspringcardiovascular risk factorsmeta-analysisdyslipidemia |
| spellingShingle | Weikai Wang Ru Lin Lan Yang Yanxia Wang Baohong Mao Xiaoying Xu Jing Yu Meta-Analysis of Cardiovascular Risk Factors in Offspring of Preeclampsia Pregnancies Diagnostics preeclampsia pregnancy offspring cardiovascular risk factors meta-analysis dyslipidemia |
| title | Meta-Analysis of Cardiovascular Risk Factors in Offspring of Preeclampsia Pregnancies |
| title_full | Meta-Analysis of Cardiovascular Risk Factors in Offspring of Preeclampsia Pregnancies |
| title_fullStr | Meta-Analysis of Cardiovascular Risk Factors in Offspring of Preeclampsia Pregnancies |
| title_full_unstemmed | Meta-Analysis of Cardiovascular Risk Factors in Offspring of Preeclampsia Pregnancies |
| title_short | Meta-Analysis of Cardiovascular Risk Factors in Offspring of Preeclampsia Pregnancies |
| title_sort | meta analysis of cardiovascular risk factors in offspring of preeclampsia pregnancies |
| topic | preeclampsia pregnancy offspring cardiovascular risk factors meta-analysis dyslipidemia |
| url | https://www.mdpi.com/2075-4418/13/4/812 |
| work_keys_str_mv | AT weikaiwang metaanalysisofcardiovascularriskfactorsinoffspringofpreeclampsiapregnancies AT rulin metaanalysisofcardiovascularriskfactorsinoffspringofpreeclampsiapregnancies AT lanyang metaanalysisofcardiovascularriskfactorsinoffspringofpreeclampsiapregnancies AT yanxiawang metaanalysisofcardiovascularriskfactorsinoffspringofpreeclampsiapregnancies AT baohongmao metaanalysisofcardiovascularriskfactorsinoffspringofpreeclampsiapregnancies AT xiaoyingxu metaanalysisofcardiovascularriskfactorsinoffspringofpreeclampsiapregnancies AT jingyu metaanalysisofcardiovascularriskfactorsinoffspringofpreeclampsiapregnancies |