Therapeutic Targeting of Protein Tyrosine Phosphatases from <i>Mycobacterium tuberculosis</i>
Tuberculosis (TB) is an airborne infectious disease caused by <i>Mycobacterium tuberculosis</i> (Mtb). According to the World Health Organization, an estimated 10 million people developed TB in 2018. The occurrence of drug-resistant TB demands therapeutic agents with novel mechanisms of...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/9/1/14 |
| _version_ | 1797543803936047104 |
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| author | Kasi Viswanatharaju Ruddraraju Devesh Aggarwal Zhong-Yin Zhang |
| author_facet | Kasi Viswanatharaju Ruddraraju Devesh Aggarwal Zhong-Yin Zhang |
| author_sort | Kasi Viswanatharaju Ruddraraju |
| collection | DOAJ |
| description | Tuberculosis (TB) is an airborne infectious disease caused by <i>Mycobacterium tuberculosis</i> (Mtb). According to the World Health Organization, an estimated 10 million people developed TB in 2018. The occurrence of drug-resistant TB demands therapeutic agents with novel mechanisms of action. Antivirulence is an alternative strategy that targets bacterial virulence factors instead of central growth pathways to treat disease. <i>Mycobacterium</i> protein tyrosine phosphatases, mPTPA and mPTPB, are secreted by Mtb into the cytoplasm of macrophages and are required for survival and growth of infection within the host. Here we present recent advances in understanding the roles of mPTPA and mPTPB in the pathogenesis of TB. We also focus on potent, selective, and well-characterized small molecule inhibitors reported in the last decade for mPTPA and mPTPB. |
| first_indexed | 2024-03-10T13:50:46Z |
| format | Article |
| id | doaj.art-d7f9708ea44d4a689578fae500fde1c9 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T13:50:46Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-d7f9708ea44d4a689578fae500fde1c92023-11-21T02:09:21ZengMDPI AGMicroorganisms2076-26072020-12-01911410.3390/microorganisms9010014Therapeutic Targeting of Protein Tyrosine Phosphatases from <i>Mycobacterium tuberculosis</i>Kasi Viswanatharaju Ruddraraju0Devesh Aggarwal1Zhong-Yin Zhang2Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USADepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USADepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USATuberculosis (TB) is an airborne infectious disease caused by <i>Mycobacterium tuberculosis</i> (Mtb). According to the World Health Organization, an estimated 10 million people developed TB in 2018. The occurrence of drug-resistant TB demands therapeutic agents with novel mechanisms of action. Antivirulence is an alternative strategy that targets bacterial virulence factors instead of central growth pathways to treat disease. <i>Mycobacterium</i> protein tyrosine phosphatases, mPTPA and mPTPB, are secreted by Mtb into the cytoplasm of macrophages and are required for survival and growth of infection within the host. Here we present recent advances in understanding the roles of mPTPA and mPTPB in the pathogenesis of TB. We also focus on potent, selective, and well-characterized small molecule inhibitors reported in the last decade for mPTPA and mPTPB.https://www.mdpi.com/2076-2607/9/1/14protein tyrosine phosphatases (PTPs)tuberculosis (TB)<i>Mycobacterium tuberculosis</i> (Mtb)signal transductionvirulence factorspathogenic microorganisms |
| spellingShingle | Kasi Viswanatharaju Ruddraraju Devesh Aggarwal Zhong-Yin Zhang Therapeutic Targeting of Protein Tyrosine Phosphatases from <i>Mycobacterium tuberculosis</i> Microorganisms protein tyrosine phosphatases (PTPs) tuberculosis (TB) <i>Mycobacterium tuberculosis</i> (Mtb) signal transduction virulence factors pathogenic microorganisms |
| title | Therapeutic Targeting of Protein Tyrosine Phosphatases from <i>Mycobacterium tuberculosis</i> |
| title_full | Therapeutic Targeting of Protein Tyrosine Phosphatases from <i>Mycobacterium tuberculosis</i> |
| title_fullStr | Therapeutic Targeting of Protein Tyrosine Phosphatases from <i>Mycobacterium tuberculosis</i> |
| title_full_unstemmed | Therapeutic Targeting of Protein Tyrosine Phosphatases from <i>Mycobacterium tuberculosis</i> |
| title_short | Therapeutic Targeting of Protein Tyrosine Phosphatases from <i>Mycobacterium tuberculosis</i> |
| title_sort | therapeutic targeting of protein tyrosine phosphatases from i mycobacterium tuberculosis i |
| topic | protein tyrosine phosphatases (PTPs) tuberculosis (TB) <i>Mycobacterium tuberculosis</i> (Mtb) signal transduction virulence factors pathogenic microorganisms |
| url | https://www.mdpi.com/2076-2607/9/1/14 |
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