Optimization of the Preformulation and Formulation Parameters in the Development of New Extended-Release Tablets Containing Felodipine
Herein, new extended-release tablets containing felodipine were developed. For the orally administered formulations, optimization of the preformulation and formulation parameters was performed to assess the performance of the dosage form. Initially, the morphological and physical characterization of...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/12/11/5333 |
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| author | Anca Lucia Pop Adina Magdalena Musuc Anca Cecilia Nicoară Emma Adriana Ozon Simona Crisan Ovidiu Nicolae Penes Bogdana Adriana Nasui Dumitru Lupuliasa Ana Andreea Secăreanu |
| author_facet | Anca Lucia Pop Adina Magdalena Musuc Anca Cecilia Nicoară Emma Adriana Ozon Simona Crisan Ovidiu Nicolae Penes Bogdana Adriana Nasui Dumitru Lupuliasa Ana Andreea Secăreanu |
| author_sort | Anca Lucia Pop |
| collection | DOAJ |
| description | Herein, new extended-release tablets containing felodipine were developed. For the orally administered formulations, optimization of the preformulation and formulation parameters was performed to assess the performance of the dosage form. Initially, the morphological and physical characterization of two forms of felodipine (microcrystalline and macrocrystalline) using Fourier transform infrared spectroscopy, differential scanning calorimetry and optical microscopy was performed. The pharmaco-technical properties of the two felodipine forms were also determined. Subsequently, formulation studies for felodipine extended-release tablets were performed. Mathematical modelling of release kinetics of felodipine from developed formulations using a power law model was also performed. Based on the influence of formulation factors on the in vitro availability of felodipine in experimental tablets, a new extended-release tablet formulation was established. |
| first_indexed | 2024-03-10T01:33:02Z |
| format | Article |
| id | doaj.art-d7f98ce7aeb74370a01e71d6c5b986e7 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T01:33:02Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-d7f98ce7aeb74370a01e71d6c5b986e72023-11-23T13:39:56ZengMDPI AGApplied Sciences2076-34172022-05-011211533310.3390/app12115333Optimization of the Preformulation and Formulation Parameters in the Development of New Extended-Release Tablets Containing FelodipineAnca Lucia Pop0Adina Magdalena Musuc1Anca Cecilia Nicoară2Emma Adriana Ozon3Simona Crisan4Ovidiu Nicolae Penes5Bogdana Adriana Nasui6Dumitru Lupuliasa7Ana Andreea Secăreanu8Department of Clinical Laboratory and Food Safety, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, Romania“Ilie Murgulescu” Institute of Physical Chemistry, 202 Spl. Independentei, 060021 Bucharest, RomaniaDepartment of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, RomaniaDepartment of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, RomaniaAC HELCOR, RDI Center, Victor Babes Street, 430082 Baia Mare, RomaniaDepartment of General Medicine, “Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021 Bucharest, RomaniaDepartment of Community Health, “Iuliu Hatieganu” University of Medicine and Pharmacy, 6 Louis Pasteur Street, 400349 Cluj-Napoca, RomaniaDepartment of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, RomaniaDepartment of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, RomaniaHerein, new extended-release tablets containing felodipine were developed. For the orally administered formulations, optimization of the preformulation and formulation parameters was performed to assess the performance of the dosage form. Initially, the morphological and physical characterization of two forms of felodipine (microcrystalline and macrocrystalline) using Fourier transform infrared spectroscopy, differential scanning calorimetry and optical microscopy was performed. The pharmaco-technical properties of the two felodipine forms were also determined. Subsequently, formulation studies for felodipine extended-release tablets were performed. Mathematical modelling of release kinetics of felodipine from developed formulations using a power law model was also performed. Based on the influence of formulation factors on the in vitro availability of felodipine in experimental tablets, a new extended-release tablet formulation was established.https://www.mdpi.com/2076-3417/12/11/5333felodipineextended-release tablettablet formulationpreformulation studies |
| spellingShingle | Anca Lucia Pop Adina Magdalena Musuc Anca Cecilia Nicoară Emma Adriana Ozon Simona Crisan Ovidiu Nicolae Penes Bogdana Adriana Nasui Dumitru Lupuliasa Ana Andreea Secăreanu Optimization of the Preformulation and Formulation Parameters in the Development of New Extended-Release Tablets Containing Felodipine Applied Sciences felodipine extended-release tablet tablet formulation preformulation studies |
| title | Optimization of the Preformulation and Formulation Parameters in the Development of New Extended-Release Tablets Containing Felodipine |
| title_full | Optimization of the Preformulation and Formulation Parameters in the Development of New Extended-Release Tablets Containing Felodipine |
| title_fullStr | Optimization of the Preformulation and Formulation Parameters in the Development of New Extended-Release Tablets Containing Felodipine |
| title_full_unstemmed | Optimization of the Preformulation and Formulation Parameters in the Development of New Extended-Release Tablets Containing Felodipine |
| title_short | Optimization of the Preformulation and Formulation Parameters in the Development of New Extended-Release Tablets Containing Felodipine |
| title_sort | optimization of the preformulation and formulation parameters in the development of new extended release tablets containing felodipine |
| topic | felodipine extended-release tablet tablet formulation preformulation studies |
| url | https://www.mdpi.com/2076-3417/12/11/5333 |
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