Changes in some haematological parameters in typhoid fever patients attending Landmark University Medical Center, Omuaran-Nigeria
Background: Typhoid or enteric fever is caused by Salmonella typhi. It is largely a disease of developing nations due to poor standard of hygiene and unavailability of potable water. The most prominent feature of the infection is fever which gradually rises to a high plateau. The prevalence of typho...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-05-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402030846X |
| _version_ | 1818414090397155328 |
|---|---|
| author | James A. Ndako Victor T. Dojumo Jeremiah A. Akinwumi Victor O. Fajobi Akinyomade O. Owolabi Oludolapo Olatinsu |
| author_facet | James A. Ndako Victor T. Dojumo Jeremiah A. Akinwumi Victor O. Fajobi Akinyomade O. Owolabi Oludolapo Olatinsu |
| author_sort | James A. Ndako |
| collection | DOAJ |
| description | Background: Typhoid or enteric fever is caused by Salmonella typhi. It is largely a disease of developing nations due to poor standard of hygiene and unavailability of potable water. The most prominent feature of the infection is fever which gradually rises to a high plateau. The prevalence of typhoid fever has been on the increase which is associated with several hematological parameters. Objectives: This study was carried out to determine the changes in various hematological parameters in our study subjects. Method: Four Hundred- (400) samples were obtained from volunteer subjects visiting the outpatient department of the Landmark University Medical Center. 200 typhoid positive samples were collected from subjects while 200 typhoid negative blood samples served as controls (From both male and female subjects each). Widal test was carried out as a confirmatory test for typhoid fever and evaluation of the hematological parameters were performed. The hematological parameters considered includes Packed Cell Volume (PCV), White Blood Cell count (WBC), Platelet count (PLT), Lymphocyte (LYMP) their implications on both male and female typhoid fever patients were also determined. Results: The result showed a significant reduction in the values for PCV, WBC, ESR and HAE concentration in typhoid positive males in comparison to typhoid negative males. In females, a significant decrease was observed in values for PCV, ESR, HAE concentration and PLT in typhoid positive females when compared to typhoid negative females. These parameters when compared showed a significant decrease recorded in PCV, ESR and HAE concentration of the typhoid positive male patients in comparison to typhoid positive female patients. Conclusion: This study implies that anemia, bone marrow suppression and hemaphagocytosis are likely resulting factors of typhoid fever due to the changes in the hematological parameters. Therefore, these parameters have to be further studied to allow for efficient management of this illness. |
| first_indexed | 2024-12-14T11:13:34Z |
| format | Article |
| id | doaj.art-d7fb751a41d141d5b34ba4c418751f5e |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-14T11:13:34Z |
| publishDate | 2020-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-d7fb751a41d141d5b34ba4c418751f5e2022-12-21T23:04:11ZengElsevierHeliyon2405-84402020-05-0165e04002Changes in some haematological parameters in typhoid fever patients attending Landmark University Medical Center, Omuaran-NigeriaJames A. Ndako0Victor T. Dojumo1Jeremiah A. Akinwumi2Victor O. Fajobi3Akinyomade O. Owolabi4Oludolapo Olatinsu5Department of Microbiology, Landmark University, Omu-Aran, Nigeria; Corresponding author.Department of Medical Laboratory Services, Landmark University Medical Center, Omu-Aran, NigeriaDepartment of Medical Laboratory Services, Landmark University Medical Center, Omu-Aran, NigeriaDepartment of Medical Laboratory Services, Landmark University Medical Center, Omu-Aran, NigeriaDepartment of Microbiology, Landmark University, Omu-Aran, NigeriaDepartment of Microbiology, Landmark University, Omu-Aran, NigeriaBackground: Typhoid or enteric fever is caused by Salmonella typhi. It is largely a disease of developing nations due to poor standard of hygiene and unavailability of potable water. The most prominent feature of the infection is fever which gradually rises to a high plateau. The prevalence of typhoid fever has been on the increase which is associated with several hematological parameters. Objectives: This study was carried out to determine the changes in various hematological parameters in our study subjects. Method: Four Hundred- (400) samples were obtained from volunteer subjects visiting the outpatient department of the Landmark University Medical Center. 200 typhoid positive samples were collected from subjects while 200 typhoid negative blood samples served as controls (From both male and female subjects each). Widal test was carried out as a confirmatory test for typhoid fever and evaluation of the hematological parameters were performed. The hematological parameters considered includes Packed Cell Volume (PCV), White Blood Cell count (WBC), Platelet count (PLT), Lymphocyte (LYMP) their implications on both male and female typhoid fever patients were also determined. Results: The result showed a significant reduction in the values for PCV, WBC, ESR and HAE concentration in typhoid positive males in comparison to typhoid negative males. In females, a significant decrease was observed in values for PCV, ESR, HAE concentration and PLT in typhoid positive females when compared to typhoid negative females. These parameters when compared showed a significant decrease recorded in PCV, ESR and HAE concentration of the typhoid positive male patients in comparison to typhoid positive female patients. Conclusion: This study implies that anemia, bone marrow suppression and hemaphagocytosis are likely resulting factors of typhoid fever due to the changes in the hematological parameters. Therefore, these parameters have to be further studied to allow for efficient management of this illness.http://www.sciencedirect.com/science/article/pii/S240584402030846XInfectious diseaseHealth sciencesTyphoid feverHematological changesMale patientsFemale patients |
| spellingShingle | James A. Ndako Victor T. Dojumo Jeremiah A. Akinwumi Victor O. Fajobi Akinyomade O. Owolabi Oludolapo Olatinsu Changes in some haematological parameters in typhoid fever patients attending Landmark University Medical Center, Omuaran-Nigeria Heliyon Infectious disease Health sciences Typhoid fever Hematological changes Male patients Female patients |
| title | Changes in some haematological parameters in typhoid fever patients attending Landmark University Medical Center, Omuaran-Nigeria |
| title_full | Changes in some haematological parameters in typhoid fever patients attending Landmark University Medical Center, Omuaran-Nigeria |
| title_fullStr | Changes in some haematological parameters in typhoid fever patients attending Landmark University Medical Center, Omuaran-Nigeria |
| title_full_unstemmed | Changes in some haematological parameters in typhoid fever patients attending Landmark University Medical Center, Omuaran-Nigeria |
| title_short | Changes in some haematological parameters in typhoid fever patients attending Landmark University Medical Center, Omuaran-Nigeria |
| title_sort | changes in some haematological parameters in typhoid fever patients attending landmark university medical center omuaran nigeria |
| topic | Infectious disease Health sciences Typhoid fever Hematological changes Male patients Female patients |
| url | http://www.sciencedirect.com/science/article/pii/S240584402030846X |
| work_keys_str_mv | AT jamesandako changesinsomehaematologicalparametersintyphoidfeverpatientsattendinglandmarkuniversitymedicalcenteromuarannigeria AT victortdojumo changesinsomehaematologicalparametersintyphoidfeverpatientsattendinglandmarkuniversitymedicalcenteromuarannigeria AT jeremiahaakinwumi changesinsomehaematologicalparametersintyphoidfeverpatientsattendinglandmarkuniversitymedicalcenteromuarannigeria AT victorofajobi changesinsomehaematologicalparametersintyphoidfeverpatientsattendinglandmarkuniversitymedicalcenteromuarannigeria AT akinyomadeoowolabi changesinsomehaematologicalparametersintyphoidfeverpatientsattendinglandmarkuniversitymedicalcenteromuarannigeria AT oludolapoolatinsu changesinsomehaematologicalparametersintyphoidfeverpatientsattendinglandmarkuniversitymedicalcenteromuarannigeria |