Recent Discoveries on the Involvement of Krüppel-Like Factor 4 in the Most Common Cancer Types
Krüppel-like factor 4 (KLF4) is a transcription factor highly conserved in evolution. It is particularly well known for its role in inducing pluripotent stem cells. In addition, KLF4 plays many roles in cancer. The results of most studies suggest that KLF4 is a tumor suppressor. However, the functio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/22/8843 |
| _version_ | 1797547166302994432 |
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| author | Agnieszka Taracha-Wisniewska Grzegorz Kotarba Sebastian Dworkin Tomasz Wilanowski |
| author_facet | Agnieszka Taracha-Wisniewska Grzegorz Kotarba Sebastian Dworkin Tomasz Wilanowski |
| author_sort | Agnieszka Taracha-Wisniewska |
| collection | DOAJ |
| description | Krüppel-like factor 4 (KLF4) is a transcription factor highly conserved in evolution. It is particularly well known for its role in inducing pluripotent stem cells. In addition, KLF4 plays many roles in cancer. The results of most studies suggest that KLF4 is a tumor suppressor. However, the functioning of KLF4 is regulated at many levels. These include regulation of transcription, alternative splicing, miRNA, post-translational modifications, subcellular localization, protein stability and interactions with other molecules. Simple experiments aimed at assaying transcript levels or protein levels fail to address this complexity and thus may deliver misleading results. Tumor subtypes are also important; for example, in prostate cancer KLF4 is highly expressed in indolent tumors where it impedes tumor progression, while it is absent from aggressive prostate tumors. KLF4 is important in regulating response to many known drugs, and it also plays a role in tumor microenvironment. More and more information is available about upstream regulators, downstream targets and signaling pathways associated with the involvement of KLF4 in cancer. Furthermore, KLF4 performs critical function in the overall regulation of tissue homeostasis, cellular integrity, and progression towards malignancy. Here we summarize and analyze the latest findings concerning this fascinating transcription factor. |
| first_indexed | 2024-03-10T14:39:24Z |
| format | Article |
| id | doaj.art-d7fb8250c397422eb203e47c53d7815a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T14:39:24Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d7fb8250c397422eb203e47c53d7815a2023-11-20T21:55:42ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-11-012122884310.3390/ijms21228843Recent Discoveries on the Involvement of Krüppel-Like Factor 4 in the Most Common Cancer TypesAgnieszka Taracha-Wisniewska0Grzegorz Kotarba1Sebastian Dworkin2Tomasz Wilanowski3Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, 1 Miecznikowa St., 02-096 Warsaw, PolandInstitute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, 1 Miecznikowa St., 02-096 Warsaw, PolandDepartment of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Bundoora, VIC 3086, AustraliaInstitute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, 1 Miecznikowa St., 02-096 Warsaw, PolandKrüppel-like factor 4 (KLF4) is a transcription factor highly conserved in evolution. It is particularly well known for its role in inducing pluripotent stem cells. In addition, KLF4 plays many roles in cancer. The results of most studies suggest that KLF4 is a tumor suppressor. However, the functioning of KLF4 is regulated at many levels. These include regulation of transcription, alternative splicing, miRNA, post-translational modifications, subcellular localization, protein stability and interactions with other molecules. Simple experiments aimed at assaying transcript levels or protein levels fail to address this complexity and thus may deliver misleading results. Tumor subtypes are also important; for example, in prostate cancer KLF4 is highly expressed in indolent tumors where it impedes tumor progression, while it is absent from aggressive prostate tumors. KLF4 is important in regulating response to many known drugs, and it also plays a role in tumor microenvironment. More and more information is available about upstream regulators, downstream targets and signaling pathways associated with the involvement of KLF4 in cancer. Furthermore, KLF4 performs critical function in the overall regulation of tissue homeostasis, cellular integrity, and progression towards malignancy. Here we summarize and analyze the latest findings concerning this fascinating transcription factor.https://www.mdpi.com/1422-0067/21/22/8843breast cancercolorectal cancergastric cancerhepatocellular carcinomaKLF4lung cancer |
| spellingShingle | Agnieszka Taracha-Wisniewska Grzegorz Kotarba Sebastian Dworkin Tomasz Wilanowski Recent Discoveries on the Involvement of Krüppel-Like Factor 4 in the Most Common Cancer Types International Journal of Molecular Sciences breast cancer colorectal cancer gastric cancer hepatocellular carcinoma KLF4 lung cancer |
| title | Recent Discoveries on the Involvement of Krüppel-Like Factor 4 in the Most Common Cancer Types |
| title_full | Recent Discoveries on the Involvement of Krüppel-Like Factor 4 in the Most Common Cancer Types |
| title_fullStr | Recent Discoveries on the Involvement of Krüppel-Like Factor 4 in the Most Common Cancer Types |
| title_full_unstemmed | Recent Discoveries on the Involvement of Krüppel-Like Factor 4 in the Most Common Cancer Types |
| title_short | Recent Discoveries on the Involvement of Krüppel-Like Factor 4 in the Most Common Cancer Types |
| title_sort | recent discoveries on the involvement of kruppel like factor 4 in the most common cancer types |
| topic | breast cancer colorectal cancer gastric cancer hepatocellular carcinoma KLF4 lung cancer |
| url | https://www.mdpi.com/1422-0067/21/22/8843 |
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