Seroprevalence of Strongyloides stercoralis infection in a South Indian adult population.
<h4>Background</h4>The prevalence of Strongyloides stercoralis infection is estimated to be 30-100 million worldwide, although this an underestimate. Most cases remain undiagnosed due to the asymptomatic nature of the infection. We wanted to estimate the seroprevalence of S. stercoralis...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-07-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0010561 |
| _version_ | 1828256221411409920 |
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| author | Saravanan Munisankar Anuradha Rajamanickam Suganthi Balasubramanian Satishwaran Muthusamy Chandra Kumar Dolla Pradeep Aravindan Menon Ponnuraja Chinnayan Christopher Whalen Paschaline Gumne Inderdeep Kaur Varma Nadimpalli Akshay Deverakonda Zhenhao Chen John David Otto Tesfalidet Habitegiyorgis Harish Kandaswamy Thomas B Nutman Subash Babu |
| author_facet | Saravanan Munisankar Anuradha Rajamanickam Suganthi Balasubramanian Satishwaran Muthusamy Chandra Kumar Dolla Pradeep Aravindan Menon Ponnuraja Chinnayan Christopher Whalen Paschaline Gumne Inderdeep Kaur Varma Nadimpalli Akshay Deverakonda Zhenhao Chen John David Otto Tesfalidet Habitegiyorgis Harish Kandaswamy Thomas B Nutman Subash Babu |
| author_sort | Saravanan Munisankar |
| collection | DOAJ |
| description | <h4>Background</h4>The prevalence of Strongyloides stercoralis infection is estimated to be 30-100 million worldwide, although this an underestimate. Most cases remain undiagnosed due to the asymptomatic nature of the infection. We wanted to estimate the seroprevalence of S. stercoralis infection in a South Indian adult population.<h4>Methods</h4>To this end, we performed community-based screening of 2351 individuals (aged 18-65) in Kanchipuram District of Tamil Nadu between 2013 and 2020. Serological testing for S. stercoralis was performed using the NIE ELISA.<h4>Results</h4>Our data shows a seroprevalence of 33% (768/2351) for S. stercoralis infection which had a higher prevalence among males 36% (386/1069) than among females 29.8% (382/1282). Adults aged ≥55 (aOR = 1.65, 95% CI: 1.25-2.18) showed higher adjusted odds of association compared with other age groups. Eosinophil levels (39%) (aOR = 1.43, 95% CI: 1.19-1.74) and hemoglobin levels (24%) (aOR = 1.25, 95% CI: 1.11-1.53) were significantly associated with S. stercoralis infection. In contrast, low BMI (aOR = 1.15, 95% CI: 0.82-1.61) or the presence of diabetes mellitus (OR = 1.18, 95% CI: 0.83-1.69) was not associated with S. stercoralis seropositivity.<h4>Conclusions</h4>Our study provides evidence for a very high baseline prevalence of S. stercoralis infection in South Indian communities and this information could provide realistic and concrete planning of control measures. |
| first_indexed | 2024-04-13T02:25:03Z |
| format | Article |
| id | doaj.art-d7fc1da6a5a34e098cbc5d7869bb67d0 |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-04-13T02:25:03Z |
| publishDate | 2022-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-d7fc1da6a5a34e098cbc5d7869bb67d02022-12-22T03:06:49ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352022-07-01167e001056110.1371/journal.pntd.0010561Seroprevalence of Strongyloides stercoralis infection in a South Indian adult population.Saravanan MunisankarAnuradha RajamanickamSuganthi BalasubramanianSatishwaran MuthusamyChandra Kumar DollaPradeep Aravindan MenonPonnuraja ChinnayanChristopher WhalenPaschaline GumneInderdeep KaurVarma NadimpalliAkshay DeverakondaZhenhao ChenJohn David OttoTesfalidet HabitegiyorgisHarish KandaswamyThomas B NutmanSubash Babu<h4>Background</h4>The prevalence of Strongyloides stercoralis infection is estimated to be 30-100 million worldwide, although this an underestimate. Most cases remain undiagnosed due to the asymptomatic nature of the infection. We wanted to estimate the seroprevalence of S. stercoralis infection in a South Indian adult population.<h4>Methods</h4>To this end, we performed community-based screening of 2351 individuals (aged 18-65) in Kanchipuram District of Tamil Nadu between 2013 and 2020. Serological testing for S. stercoralis was performed using the NIE ELISA.<h4>Results</h4>Our data shows a seroprevalence of 33% (768/2351) for S. stercoralis infection which had a higher prevalence among males 36% (386/1069) than among females 29.8% (382/1282). Adults aged ≥55 (aOR = 1.65, 95% CI: 1.25-2.18) showed higher adjusted odds of association compared with other age groups. Eosinophil levels (39%) (aOR = 1.43, 95% CI: 1.19-1.74) and hemoglobin levels (24%) (aOR = 1.25, 95% CI: 1.11-1.53) were significantly associated with S. stercoralis infection. In contrast, low BMI (aOR = 1.15, 95% CI: 0.82-1.61) or the presence of diabetes mellitus (OR = 1.18, 95% CI: 0.83-1.69) was not associated with S. stercoralis seropositivity.<h4>Conclusions</h4>Our study provides evidence for a very high baseline prevalence of S. stercoralis infection in South Indian communities and this information could provide realistic and concrete planning of control measures.https://doi.org/10.1371/journal.pntd.0010561 |
| spellingShingle | Saravanan Munisankar Anuradha Rajamanickam Suganthi Balasubramanian Satishwaran Muthusamy Chandra Kumar Dolla Pradeep Aravindan Menon Ponnuraja Chinnayan Christopher Whalen Paschaline Gumne Inderdeep Kaur Varma Nadimpalli Akshay Deverakonda Zhenhao Chen John David Otto Tesfalidet Habitegiyorgis Harish Kandaswamy Thomas B Nutman Subash Babu Seroprevalence of Strongyloides stercoralis infection in a South Indian adult population. PLoS Neglected Tropical Diseases |
| title | Seroprevalence of Strongyloides stercoralis infection in a South Indian adult population. |
| title_full | Seroprevalence of Strongyloides stercoralis infection in a South Indian adult population. |
| title_fullStr | Seroprevalence of Strongyloides stercoralis infection in a South Indian adult population. |
| title_full_unstemmed | Seroprevalence of Strongyloides stercoralis infection in a South Indian adult population. |
| title_short | Seroprevalence of Strongyloides stercoralis infection in a South Indian adult population. |
| title_sort | seroprevalence of strongyloides stercoralis infection in a south indian adult population |
| url | https://doi.org/10.1371/journal.pntd.0010561 |
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