Predictive value of neutrophil-to-lymphocyte and platelet ratio in in-hospital mortality in septic patients
Background: Among critically ill patients in the intensive care unit (ICU), sepsis is an urgent global public health problem due to its high incidence, high mortality rate and complex pathogenesis. Objective: This study was to evaluate the predictive value of neutrophil-to-lymphocyte ratio (NLR), an...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844022027864 |
| _version_ | 1797987882012508160 |
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| author | Yiming Shi Chunhua Yang Lei Chen Min Cheng Wenfeng Xie |
| author_facet | Yiming Shi Chunhua Yang Lei Chen Min Cheng Wenfeng Xie |
| author_sort | Yiming Shi |
| collection | DOAJ |
| description | Background: Among critically ill patients in the intensive care unit (ICU), sepsis is an urgent global public health problem due to its high incidence, high mortality rate and complex pathogenesis. Objective: This study was to evaluate the predictive value of neutrophil-to-lymphocyte ratio (NLR), and neutrophil-to-lymphocyte and platelet ratio (NLPR) in-hospital mortality in septic patients on days 1, 3 and 5 in ICU. Methods: The data of septic patients admitted to the ICU of the Sixth Affiliated Hospital of Sun Yat-sen University from March, 2018 to July, 2019 were collected. NLR and NLPR were calculated and multivariate logistic regression analysis was performed to identify the relationship between them and in-hospital mortality, respectively. Receiver operating characteristic curve (ROC) was used to determine the efficacy and optimal cutoff value of diagnostic tests. Results: A total of 173 septic patients were included in this analysis, including 108 cases in the survival group and 65 in the death group, with a total mortality rate of 37.6%. A multivariate logistic regression analysis showed that NLR on day 5 was independently correlated with in-hospital mortality rate (OR 1.041, 95% CI: 1.008–1.074), and Day 5 NLPR was also independently associated with in-hospital mortality rate (OR 1.020, 95% CI: 1.001–1.040). The areas under the receiver operating characteristic curve (AUC) of the NLR on days 1 and 3 was 0.513 and 0.542 respectively, and the optimal cutoff value were 23.16 and 15.48, and the AUC of the NLR on day 5 was 0.589, and the best cutoff value was 15.85. The AUC of NLPR on day 1 and 3 was 0.517 and 0.547, respectively, and the optimal cutoff value was 10.25 and 18.47. The AUC of NLPR on day 5 was the largest, 0.654, and the optimal cutoff value was 8.22. After combined NLPR on day 5 with age and sequential organ failure assessment (SOFA) scores, the AUC increase to 0.718. Among the joint predictors, the optimal cutoff value for NLPR on day 5 was 9.31. Conclusion: We found that Day 5 NLPR and NLR were independently correlated with in-hospital mortality. Day 5 NLPR Combined with age and SOFA scores may be help predict mortality in ICU septic hospitalized patients. |
| first_indexed | 2024-04-11T07:55:18Z |
| format | Article |
| id | doaj.art-d7fccbeced47406189ecb78b18d2377e |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-11T07:55:18Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-d7fccbeced47406189ecb78b18d2377e2022-12-22T04:35:58ZengElsevierHeliyon2405-84402022-11-01811e11498Predictive value of neutrophil-to-lymphocyte and platelet ratio in in-hospital mortality in septic patientsYiming Shi0Chunhua Yang1Lei Chen2Min Cheng3Wenfeng Xie4Intensive Care Unit, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, PR ChinaIntensive Care Unit, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, PR ChinaIntensive Care Unit, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, PR ChinaIntensive Care Unit, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, PR ChinaCorresponding author.; Intensive Care Unit, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, PR ChinaBackground: Among critically ill patients in the intensive care unit (ICU), sepsis is an urgent global public health problem due to its high incidence, high mortality rate and complex pathogenesis. Objective: This study was to evaluate the predictive value of neutrophil-to-lymphocyte ratio (NLR), and neutrophil-to-lymphocyte and platelet ratio (NLPR) in-hospital mortality in septic patients on days 1, 3 and 5 in ICU. Methods: The data of septic patients admitted to the ICU of the Sixth Affiliated Hospital of Sun Yat-sen University from March, 2018 to July, 2019 were collected. NLR and NLPR were calculated and multivariate logistic regression analysis was performed to identify the relationship between them and in-hospital mortality, respectively. Receiver operating characteristic curve (ROC) was used to determine the efficacy and optimal cutoff value of diagnostic tests. Results: A total of 173 septic patients were included in this analysis, including 108 cases in the survival group and 65 in the death group, with a total mortality rate of 37.6%. A multivariate logistic regression analysis showed that NLR on day 5 was independently correlated with in-hospital mortality rate (OR 1.041, 95% CI: 1.008–1.074), and Day 5 NLPR was also independently associated with in-hospital mortality rate (OR 1.020, 95% CI: 1.001–1.040). The areas under the receiver operating characteristic curve (AUC) of the NLR on days 1 and 3 was 0.513 and 0.542 respectively, and the optimal cutoff value were 23.16 and 15.48, and the AUC of the NLR on day 5 was 0.589, and the best cutoff value was 15.85. The AUC of NLPR on day 1 and 3 was 0.517 and 0.547, respectively, and the optimal cutoff value was 10.25 and 18.47. The AUC of NLPR on day 5 was the largest, 0.654, and the optimal cutoff value was 8.22. After combined NLPR on day 5 with age and sequential organ failure assessment (SOFA) scores, the AUC increase to 0.718. Among the joint predictors, the optimal cutoff value for NLPR on day 5 was 9.31. Conclusion: We found that Day 5 NLPR and NLR were independently correlated with in-hospital mortality. Day 5 NLPR Combined with age and SOFA scores may be help predict mortality in ICU septic hospitalized patients.http://www.sciencedirect.com/science/article/pii/S2405844022027864SepsisNeutrophilLymphocytePlateletMortality |
| spellingShingle | Yiming Shi Chunhua Yang Lei Chen Min Cheng Wenfeng Xie Predictive value of neutrophil-to-lymphocyte and platelet ratio in in-hospital mortality in septic patients Heliyon Sepsis Neutrophil Lymphocyte Platelet Mortality |
| title | Predictive value of neutrophil-to-lymphocyte and platelet ratio in in-hospital mortality in septic patients |
| title_full | Predictive value of neutrophil-to-lymphocyte and platelet ratio in in-hospital mortality in septic patients |
| title_fullStr | Predictive value of neutrophil-to-lymphocyte and platelet ratio in in-hospital mortality in septic patients |
| title_full_unstemmed | Predictive value of neutrophil-to-lymphocyte and platelet ratio in in-hospital mortality in septic patients |
| title_short | Predictive value of neutrophil-to-lymphocyte and platelet ratio in in-hospital mortality in septic patients |
| title_sort | predictive value of neutrophil to lymphocyte and platelet ratio in in hospital mortality in septic patients |
| topic | Sepsis Neutrophil Lymphocyte Platelet Mortality |
| url | http://www.sciencedirect.com/science/article/pii/S2405844022027864 |
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