Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases

Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases

Reparative hepatocyte replication is impaired in chronic liver disease, contributing to disease progression; however, the underlying mechanism remains elusive. Here, we identify Map3k14 (also known as NIK) and its substrate Chuk (also called IKKα) as unrecognized suppressors of hepatocyte replicatio...

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Bibliographic Details
Main Authors: Yi Xiong, Adriana Souza Torsoni, Feihua Wu, Hong Shen, Yan Liu, Xiao Zhong, Mark J Canet, Yatrik M Shah, M Bishr Omary, Yong Liu, Liangyou Rui
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-08-01
Series:eLife
Subjects:
liver regeneration
liver injury
liver inflammation
Online Access:https://elifesciences.org/articles/34152

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